Bedside diagnosis, including but not limited to the physical examination, can be lifesaving in the setting of critical illness and is a core competency in both medical school and at the postgraduate level. Data as to the clinical usefulness of bedside diagnosis in the modern intensive care unit (ICU) is sparse, however, and there are no clinical guidelines addressing performance, interpretation, and usefulness of the bedside assessment in critically ill patients. Bedside assessment and physical examination are used in a heterogeneous manner across institutions and even across ICUs within the same institution, which has implications for medical education, patient care, and the overuse/ misuse of diagnostic testing. In this commentary, we review the existing data addressing bedside diagnosis in the ICU, describe various models of bedside assessment use in the ICU based on our clinical practice and on the limited evidence base, share our practical "checklist-based" approach to bedside assessment in the critically ill patient, and advocate for more formal study of physical examination and bedside assessment in the ICU to enhance clinical practice.Keywords: bedside diagnosis; critical care; patient-physician relationship; clinical skills; technology A 64-year-old man was seen on rounds in the intensive care unit (ICU) on Postoperative Day 5 from aortic valve replacement. His course included postoperative atrial fibrillation. Before rounds, he had been examined by multiple members of the ICU team, who described him as "confused." On examination, he had a left facial droop; 3/5 left hand, arm, and leg strength; and left-sided neglect. Given that his neurologic examination was normal 3 hours previously, acute neurology consultation and neuroimaging were obtained, confirming right middle cerebral artery occlusion. Urgent catheter-based thrombectomy was performed with improvement in symptoms. Ultimately, he was discharged with minimal deficit.A 73-year-old woman was admitted to the medical ICU for hypotension and shock. White cells were visualized on urine microscopy and a working diagnosis of urosepsis was made. Her hypotension was refractory to multiple pressors. On examination, she had a narrow pulse pressure with the blood pressure 76/60 mm Hg, and the jugular venous pressure was elevated to greater than 20 cm H 2 O. The femoral and radial pulses disappeared completely with spontaneous inspiration, constituting significant pulsus paradoxus. Urgent transthoracic echocardiogram confirmed large pericardial effusion with tamponade. The patient underwent pericardiocentesis with resolution of shock and hypotension.Physical examination and bedside diagnosis remains a cornerstone of patient evaluation and is a core competency in medical school and postgraduate medical education curricula. As the previous anecdotes illustrate, a bedside assessment can be lifesaving in the setting of critical illness. Nonetheless, data as to the usefulness of physical diagnosis in the ICU are sparse, and to our knowledge no professional...