Prevalence of Cortical Osteoporosis in Mild and Severe Primary Hyperparathyroidism and its Relationship With Bone Markers and Vitamin D Status

Bandeira, Francisco; Griz, Luiz; Bandeira, Cristina; Pinho, Jorge da Silva; Lucena, Cynthia Salgado; Alencar, Clineu; Diniz, Erik Trovão

doi:10.1016/j.jocd.2008.11.005

Cited by 20 publications

(13 citation statements)

References 14 publications

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“…Also in osteopenic women, primary hyperparathyroidism was the most commonly diagnosed disease. Our observations are in line with the epidemiological evidence showing that women are about 3 times more often affected by primary hyperparathyroidism than men 34,35,36 . Therefore, our results emphasize the importance of serum calcium screening in all subjects with osteoporosis or reduced bone mass.…”

Section: Rheumatologysupporting

confidence: 92%

Secondary Osteoporosis in Men and Women: Clinical Challenge of an Unresolved Issue

Romagnoli¹,

Fiacco²,

Russo³

et al. 2011

J Rheumatol

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Section: Rheumatologysupporting

confidence: 92%

Secondary Osteoporosis in Men and Women: Clinical Challenge of an Unresolved Issue

Romagnoli¹,

Fiacco²,

Russo³

et al. 2011

J Rheumatol

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“…The pathophysiological mechanisms responsible for the low serum 25(OH)D level in PHPT are not completely clarified. The data obtained from several studies suggest that vitamin D status might influence the clinical and biological expression of PHTP [1,2,[4][5][6][7][8][9][10][11][12][13][14][15] and even recovery after surgical treatment [11,16,17], although some authors have not found such an association [18,19].…”

Section: Introductionmentioning

confidence: 99%

Biochemical effects of calcifediol supplementation in mild, asymptomatic, hyperparathyroidism with concomitant vitamin D deficiency

Isidro

Ruano

2009

Endocr

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It has been proposed to cautiously supplement with vitamin D to any patient with asymptomatic primary hyperparathyroidism (PHTP) and a plasma 25-hydroxyvitamin D [25(OH)D] concentration <50 nmol/l. Evidence about the safeness of this intervention is limited to two studies. Our aim was to prospectively assess the biochemical effects of one-year 25(OH)D supplementation in this context. Twenty-seven patients were included in this study. Calcifediol was started at a dose of 480-960 IU/24 h (8-16 microg/24 h) and adjusted up to a maximum of 960 IU/24 h (16 microg/24 h). Basal calcium, phosphate, albumin, total alkaline phosphatase (ALP), creatinine, 24 h calcium urinary excretion, intact PTH (iPTH) and 25(OH)D were measured before and during vitamin D supplementation. The mean basal 25(OH)D was 28.7 +/- 8.0 nmol/l, and at 12 months was 71.5 +/- 32.5 nmol/l (P = 0.00 vs. baseline). After 3, 6 and 12 months iPTH levels were 141.7 +/- 108.4 ng/l (P = 0.00 vs. baseline), 131.1 +/- 95.7 ng/l (P = 0.03 vs. baseline) and 162.2 +/- 139.3 ng/l (P = ns vs. baseline). Mean calcium did not change. Mean urinary calcium excretion increased significantly (basal: 5.7 +/- 2.9 mmol/24 h, 12 months: 7.9 +/- 4.9 mmol/24 h, P = 0.02). Cautious calcifediol supplementation significantly increased mean 25(OH)D and temporarily reduced mean iPTH. It did not change mean serum calcium, but urinary calcium excretion increased significantly. We suggest that serum calcium and 24 h calciuria be measured at regular intervals in patients with PHTP, while on calcifediol supplementation.

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“…This, together with the fact that the lumbar spine, a trabecular site, is less affected, has given rise to the notion that the trabecular skeleton may be relatively preserved in patients with asymptomatic PHPT. 35 Recent data obtained by high resolution QCT imaging as well as other imaging modalities have raised questions about the selectivity of PTH to erode cortical bone in mild PHPT. [36][37][38][39] After parathyroidectomy, BMD increases even in those with minimal evidence of demineralization.…”

Section: Bone Disease In Primary Hyperparathyroidismmentioning

confidence: 99%

Clinical Presentation of Primary Hyperparathyroidism

Bandeira

Correia

2015

The Parathyroids

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Prevalence of Cortical Osteoporosis in Mild and Severe Primary Hyperparathyroidism and its Relationship With Bone Markers and Vitamin D Status

Cited by 20 publications

References 14 publications

Secondary Osteoporosis in Men and Women: Clinical Challenge of an Unresolved Issue

Secondary Osteoporosis in Men and Women: Clinical Challenge of an Unresolved Issue

Biochemical effects of calcifediol supplementation in mild, asymptomatic, hyperparathyroidism with concomitant vitamin D deficiency

Clinical Presentation of Primary Hyperparathyroidism

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