Prevalence of Cysts in Seminal Tract and Abnormal Semen Parameters in Patients with Autosomal Dominant Polycystic Kidney Disease

Torra, Roser; Sarquella, Joaquim; Calabia, Jordi; Martí, J.L. Palmero; Ars, Elisabet; Fernández-Llama, Patricia; Ballarín, J.

doi:10.2215/cjn.05311107

Cited by 60 publications

(46 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Human ciliopathies like primary dyskinesia or autosomal dominant polycystic kidney disease can be associated with infertility [22,23]. There is only one report of male infertility due to NPHP in a family with homozygous NPHP4 truncating mutation.…”

Section: Discussionmentioning

confidence: 99%

Identification of an NPHP1 deletion causing adult form of nephronophthisis

et al. 2015

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Identification of an NPHP1 deletion causing adult form of nephronophthisis

et al. 2015

View full text Add to dashboard Cite

show abstract

“…This incidence of bilaterally is described as up to 43% in the literature (9). The ectopic ureter insertion into the seminal vesicle is extremely uncommon reported with accompanying by reflux and obstruction and therefore a primary adenocarcinoma could cause this (10).…”

Section: Discussionmentioning

confidence: 99%

Congenital seminal vesicle cyst accompanying with ipsilateral renal agenesis in an adolescent patient: A pediatric radiologist approach to Zinner’s syndrome

Özkan

Bilgici

Sahin

et al. 2015

The Egyptian Journal of Radiology and Nuclear Medicine

View full text Add to dashboard Cite

A fifteen-year-old boy who had complaints of left sided pelvic pain with known ipsilateral left renal agenesia was referred to pediatric radiology department. Incidentally, his sonography examination revealed a dilated tubular structure located in the retro-vesicular region from cephalic to prostate. Contrast enhanced pelvic MRI showed a huge seminal vesicle cyst which is over 6 cm without a mass effect near the aspect border of the prostate and bladder. The patient was diagnosed with Zinner syndrome. The patient doesn't have new complaint with no definite increase in the diameter of the cyst. In this case presentation we are discussing the Zinner syndrome's imaging findings from a pediatric radiologist approach with a brief review of the literature.

show abstract

“…Information on the clinical significance of these cysts is limited. Torra et al reported recently that the ratio of cysts in the seminal vesicles in ADPKD was 43% (4). They demonstrated that sperm abnormalities, although frequent, were not related to these cysts.…”

Section: Introductionmentioning

confidence: 96%

Is There any Effect of Urogenital Cysts on Semen Parameters in Autosomal Dominant Polycystic Kidney Disease?

Uzun¹,

Öztürk²,

Gürsu³

et al. 2015

Turk Neph Dial Transpl

View full text Add to dashboard Cite

OBJECTIVE:Autosomal dominant polycystic kidney disease (ADPKD) is a systemic disease with cysts in many organs including the urogenital tract. The aim of the study was to evaluate the relationship between urogenital cysts, semen pathologies and infertility in ADPKD. MATERIAL and METHODS:Male ADPKD patients aged 18-60 with creatinine clearance years higher than 60 ml/min were included. All patients had magnetic resonance imaging of the urinary system and pelvis, scrotal Doppler ultrasonography and sperm analysis. The results were compared with those of a healthy control group. RESULTS: 27 patients and 17 volunteers were included. Seminal vesicle and prostate cysts were detected in four (15%) and six (22%) patients, respectively. Five of the 23 married patients (21%) had infertility and this rate was higher than in the control group (p=0.044). The ratio of sperms with normal morphology and progressive motility was lower, and the rate of hypospermia, oligozoospermia, azospermia, asthenozoospermia and teratozoospermia were higher in the patient group. There was no significant difference between patients with/without urogenital cysts regarding seminal pathologies. CONCLUSION:Seminal abnormalities and infertility are more frequent in patients with ADPKD. Defects in spermatogenesis and sperm motility may be related to urogenital cysts as well as ciliary pathologies. There is a need for further studies evaluating the role of urogenital cysts in semen pathologies. KEY WORDS:Autosomal dominant polycystic kidney disease, Cyst, Spermiogram, Infertility ÖZ AMAÇ: Otozomal dominant polikistik böbrek hastalığı (ODPBH) ürogenital sistemle birlikte birçok organda kist oluşumuna neden olabilen sistemik bir hastalıktır. Çalışmada, ODPBH olan bireylerde ürogenital kistler ile semen patolojileri ve infertilite ilişkisi değerlendirilmiştir. GEREÇ ve YÖNTEMLER:Çalışmaya 18-60 yaşları arasında, kreatinin klirensi 60 ml/dakika/1.73 m2'nin üzerinde, ODPBH olan erkekler dahil edildi. Tüm hastalara üriner sistem ve pelvik manyetik rezonans(MR) inceleme, skrotal Doppler ultrasonografi ve semen analizi yapıldı. Sonuçlar sağlıklı kontrol grubu ile karşılaştırıldı. BULGULAR:Yirmiyedi hasta ve 17 gönüllü çalışmaya dahil edildi. Seminal vezikül kisti 4(%15), prostat kisti 6 (%22) hastada tespit edildi. Kontrol grubundan daha sık olarak, evli olan 23 hastanın 5'inde (%21) infertilite mevcuttu (p=0.044). Normal morfolojili sperm oranları ve ileri motilite daha düşük, hipospermi, oligozoospermi, azospermi, asthenozoospermi ve teratozoospermi oranları hasta grubunda daha yüksekti. Ürogenital kisti olan/olmayan hastalarda semen patolojileri açısından anlamlı fark yoktu. SONUÇ:Seminal anormallikler ve infertilite ODPBH olanlarda daha sıktır. Spermatogenez ve sperm motilite defektleri siliar patolojiler gibi urogenital kistlerle ilişkili olabilir. Ürogenital kistlerin semen patolojilerindeki rolünü değerlendirmek için ileri çalışmalara ihtiyaç vardır.

show abstract

Prevalence of Cysts in Seminal Tract and Abnormal Semen Parameters in Patients with Autosomal Dominant Polycystic Kidney Disease

Cited by 60 publications

References 19 publications

Identification of an NPHP1 deletion causing adult form of nephronophthisis

Identification of an NPHP1 deletion causing adult form of nephronophthisis

Congenital seminal vesicle cyst accompanying with ipsilateral renal agenesis in an adolescent patient: A pediatric radiologist approach to Zinner’s syndrome

Is There any Effect of Urogenital Cysts on Semen Parameters in Autosomal Dominant Polycystic Kidney Disease?

Contact Info

Product

Resources

About

Prevalence of Cysts in Seminal Tract and Abnormal Semen Parameters in Patients with Autosomal Dominant Polycystic Kidney Disease

Cited by 60 publications

References 19 publications

Identification of an NPHP1 deletion causing adult form of nephronophthisis

Identification of an NPHP1 deletion causing adult form of nephronophthisis

Congenital seminal vesicle cyst accompanying with ipsilateral renal agenesis in an adolescent patient: A pediatric radiologist approach to Zinner’s syndrome

Is There any Effect of Urogenital Cysts on Semen Parameters in ￼Autosomal Dominant Polycystic Kidney Disease?

Contact Info

Product

Resources

About

Is There any Effect of Urogenital Cysts on Semen Parameters in Autosomal Dominant Polycystic Kidney Disease?