Prevalence of cytopenia and its associated factors among HIV infected adults on highly active antiretroviral therapy at Mehal Meda Hospital, North Shewa Zone, Ethiopia

Gebreweld, Angesom; Fiseha, Temesgen; Girma, Nibret; Haileslasie, Haftay; Gebretsadik, Daniel

doi:10.1371/journal.pone.0239215

Cited by 10 publications

(14 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These findings were similar to several studies that reported the leucopenia, neutropenia, and lymphopenia was more prevalent among patients with CD4 count <200 cells/µL. 2 , 3 , 16 The prevalence of leucopenia and lymphopenia with decreased CD4 count was significantly associated before initiation of ART, but it did not significantly associate after ART initiation, this may be due to ART bringing a statistical increment into the WBC count. 11 , 13 The present study revealed that patients on AZT-based ART regimen had a higher prevalence of leucopenia, neutropenia, and lymphopenia compared to TDF-based ART regimen.…”

Section: Discussionsupporting

confidence: 90%

“…This was in line with previous studies. 2,21 According to the present study, the prevalence of leucopenia, neutropenia, and lymphopenia were increased with decreasing in CD4 count both before and after the initiation of ART. Leucopenia, neutropenia, and lymphopenia were more prevalent among HIV-positive patients whose CD4 count was <200 cells/µL.…”

Section: Discussionsupporting

confidence: 60%

“… 23 In the present study the prevalence of leucopenia was elevated in patients whose age is ≥50 years old, which is in agreement with another study. 2 The increase in the prevalence of leucopenia with age might be due to a higher incidence of myelodysplasia in older patients. 9 However, leucopenia did not show a statistically significant difference with sex and age.…”

Section: Discussionmentioning

confidence: 99%

“…The cause of HIV-related leucopenia is multifactorial, which includes a direct effect of HIV, autoimmune disease, neoplasm and ART drugs (especially zidovudine-based regimen), cotrimoxazole, and opportunistic infection. [2][3][4] The prevalence of leucopenia is higher among treatment naïve people than treated ones in most studies. [3][4][5] The use of antiretroviral therapy (ART) improves total white blood cell count by preventing suppression of bone marrow cells from the HIV virus and it blocks the interference of virus in the hematopoiesis process.…”

Section: Introductionmentioning

confidence: 99%

“…present study conducted in Ethiopia and Ghana, it revealed an increment in the prevalence of leucopenia, neutropenia, and lymphopenia after initiation of AZT. 2,4 However, neutropenia did not show a statistically significant difference with the AZT-based ART regimen. The high prevalence of leucopenia, neutropenia, and lymphopenia may be due to the suppression of bone marrow by Zidovudine-based therapy.…”

mentioning

confidence: 95%

See 4 more Smart Citations

Prevalence of Leucopenia and Associated Factors before and after Initiation of ART among HIV-Infected Patients, North East Ethiopia: Cross-Sectional Study

Talargia

Teshome

Aynalem

et al. 2021

JBM

View full text Add to dashboard Cite

Background: Leucopenia is the commonest hematological abnormaly that occurs in patients with human immune deficiency virus (HIV) infection. The magnitude and related factors of leucopenia during the time of ART are not characterized in Ethiopia. This study aimed to assess the prevalence of leucopenia before and after the initiation of ART among HIV patients attending Debre Berhan Referral Hospital (DBRH), North East Ethiopia. Methods: A cross-sectional study was conducted from September to December 2020 in DBRH, North-East Ethiopia. A total of 272 patients on ART were selected by simple random sampling techniques. Socio-demographic and clinical characteristics of the study participants were collected by standard questionnaires. Measurements of leucocyte count and CD4 counts were made by Sysmex XT 2000i hematology analyzer and BD FACS count CD4 analyzer, respectively. Statistical analysis of data was done by SPSS version 23. Logistic regression was done and a P-value<0.05 was taken as statistically significant. Results: The prevalence of leucopenia, neutropenia, and lymphopenia were 20.9%, 7.0%, and 6.6% before initiation of ART and 15.4%, 1.1, and 4.4% after initiation of ART, respectively. There was a significant difference in total white blood cell count, absolute neutrophil count, and total lymphocyte count between patients on ART and ART naïve patients. HIV patients whose cluster of differentiation (CD4) counts were <200 cells/µL and patients on a zidovudine (AZT)-based regimen were more likely to have leucopenia than HIV patients whose CD4 counts were ≥ 200 cells/µL and on a tenofovir (TDF)-based regimen. Conclusion:In this study, the prevalence of leucopenia, neutropenia, and lymphopenia has shown a significant decrement after the initiation of ART. HIV patients with low CD4 count and on an AZT-based regimen are more likely to have leucopenia, neutropenia, and lymphopenia. Based on our findings, we recommend that the health care professional routinely investigate and should treat leucopenia.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 60%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 95%

See 3 more Smart Citations

Prevalence of Leucopenia and Associated Factors before and after Initiation of ART among HIV-Infected Patients, North East Ethiopia: Cross-Sectional Study

Talargia

Teshome

Aynalem

et al. 2021

JBM

View full text Add to dashboard Cite

show abstract

Development and Evaluation of a Nomogram for Predicting the Outcome of Immune Reconstitution Among HIV/AIDS Patients Receiving Antiretroviral Therapy in China

Wang,

Liu,

Zhang

et al. 2023

Advanced Biology

View full text Add to dashboard Cite

This study aims to develop and evaluate a model to predict the immune reconstitution among HIV/AIDS patients after antiretroviral therapy (ART). A total of 502 HIV/AIDS patients are randomized to the training cohort and evaluation cohort. Least absolute shrinkage and selection operator (LASSO) regression and multivariate logistic regression analysis are performed to identify the indicators and establish the nomogram for predicting the immune reconstitution. Decision curve analysis (DCA) and clinical impact curve (CIC) are used to evaluate the clinical effectiveness of the nomogram. Predictive factors included white blood cells (WBC), baseline CD4+ T‐cell counts (baseline CD4), ratio of effector regulatory T cells to resting regulatory T cells (eTreg/rTreg) and low‐density lipoprotein cholesterol (LDL‐C) and are incorporated into the nomogram. The area under the curve (AUC) is 0.812 (95% CI, 0.767∼0.851) and 0.794 (95%CI, 0.719∼0.857) in the training cohort and evaluation cohort, respectively. The calibration curve shows a high consistency between the predicted and actual observations. Moreover, DCA and CIC indicate that the nomogram has a superior net benefit in predicting poor immune reconstitution. A simple‐to‐use nomogram containing four routinely collected variables is developed and internally evaluated and can be used to predict the poor immune reconstitution in HIV/AIDS patients after ART.

show abstract

The global prevalence of thrombocytopenia among HIV-infected adults: A systematic review and meta-analysis

Getawa

Aynalem

Bayleyegn

et al. 2021

International Journal of Infectious Diseases

View full text Add to dashboard Cite

Prevalence of cytopenia and its associated factors among HIV infected adults on highly active antiretroviral therapy at Mehal Meda Hospital, North Shewa Zone, Ethiopia

Cited by 10 publications

References 36 publications

Prevalence of Leucopenia and Associated Factors before and after Initiation of ART among HIV-Infected Patients, North East Ethiopia: Cross-Sectional Study

Prevalence of Leucopenia and Associated Factors before and after Initiation of ART among HIV-Infected Patients, North East Ethiopia: Cross-Sectional Study

Development and Evaluation of a Nomogram for Predicting the Outcome of Immune Reconstitution Among HIV/AIDS Patients Receiving Antiretroviral Therapy in China

The global prevalence of thrombocytopenia among HIV-infected adults: A systematic review and meta-analysis

Contact Info

Product

Resources

About