Prevalence of Dehiscences and Fenestrations in Modern American Skulls

Rupprecht, Robert D.; Horning, Gregory M.; Nicoll, Brian K.; Cohen, Mark E.

doi:10.1902/jop.2001.72.6.722

Cited by 116 publications

(116 citation statements)

References 15 publications

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“…Besides, the high prevalence of alveolar fenestrations and dehiscences were found in skull studies. 1,2 Loss of periodontal support tissue will lead to loosening of the teeth and affect oral function, while conventional periodontal surgical approaches such as root surface conditioning or guided tissue regeneration result in limited new bone, cementum, and periodontal ligament formation. Moreover, the formation of new bone and cementum with supportive periodontal ligament is the ultimate objective for periodontal tissue regeneration, but current regeneration therapies are incapable of achieving this in a predictable way.…”

Section: Introductionmentioning

confidence: 99%

“…More importantly, in addition to the ability to differentiate into osteoblast-like cells and adipocytes, PDLSCs can also specifically differentiate into periodontal cells, such as cementoblast-like cells and collagen forming cells in vitro, and they possess the capacity to generate a cementum/PDL-like structure when they were transplanted into nude mouse and preclinical periodontal defect models. [5][6][7][8][9][10][11][12] Conventional hydroxyapatite (Ca 10 (PO 4 ) 6 (OH) 2 , HA) bioceramics had been used in periodontal bone tissue repair for their chemical similarity to bone mineral and their excellent biological activity and osteoconductivity. 13 However, it is reported that HA bioceramics lack osteoinductive ability, and consequently possess limited ability to form an interface with new bone tissue and hence hamper the new bone formation.…”

Section: Introductionmentioning

confidence: 99%

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Effect of micro-nano-hybrid structured hydroxyapatite bioceramics on osteogenic and cementogenic differentiation of human periodontal ligament stem cell via Wnt signaling pathway

Mao¹,

Liu²,

Zhao³

et al. 2015

IJN

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The surface structure of bioceramic scaffolds is crucial for its bioactivity and osteoinductive ability, and in recent years, human periodontal ligament stem cells have been certified to possess high osteogenic and cementogenic differential ability. In the present study, hydroxyapatite (HA) bioceramics with micro-nano-hybrid surface (mnHA [the hybrid of nanorods and microrods]) were fabricated via hydrothermal reaction of the α-tricalcium phosphate granules as precursors in aqueous solution, and the effects of mnHA on the attachment, proliferation, osteogenic and cementogenic differentiations of human periodontal ligament stem cells as well as the related mechanisms were systematically investigated. The results showed that mnHA bioceramics could promote cell adhesion, proliferation, alkaline phosphatase (ALP) activity, and expression of osteogenic/cementogenic-related markers including runt-related transcription factor 2 (Runx2), ALP, osteocalcin (OCN), cementum attachment protein (CAP), and cementum protein (CEMP) as compared to the HA bioceramics with flat and dense surface. Moreover, mnHA bioceramics stimulated gene expression of low-density lipoprotein receptor-related protein 5 ( LRP5 ) and β-catenin , which are the key genes of canonical Wnt signaling. Moreover, the stimulatory effect on ALP activity and osteogenic and cementogenic gene expression, including that of ALP, OCN, CAP, CEMP, and Runx2 of mnHA bioceramics could be repressed by canonical Wnt signaling inhibitor dickkopf1 (Dkk1). The results suggested that the HA bioceramics with mnHA could act as promising grafts for periodontal tissue regeneration.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of micro-nano-hybrid structured hydroxyapatite bioceramics on osteogenic and cementogenic differentiation of human periodontal ligament stem cell via Wnt signaling pathway

Mao¹,

Liu²,

Zhao³

et al. 2015

IJN

View full text Add to dashboard Cite

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“…Dehiscence and fenestration presence were also identified on the 30 koala skulls according to the methods of Rupprecht (2001) and Tal (Tal, 1983). On the birooted or unirooted teeth, only the buccal or lingual/palatal surfaces were examined.…”

Section: Dehiscences and Fenestrationsmentioning

confidence: 99%

Oral health in South East Queensland Koalas: Prevalence of periodontal disease and other pathologies

Pettett¹

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The koala (Phascolarctos cinereus) is one of Australia's most highly specialised folivores with a diet exclusively of eucalyptus leaves to provide all nutritive needs. For this it is dependent on good dentition for optimal health and quality of life. The purpose of this study was to characterise and describe the level of oral health and disease in koalas and then create tools for ongoing analysis.The historical records over a 17-year period were noted for the koalas admitted to the Moggill Koala Hospital in South East Queensland. Further, in this study the conclusions were that oral health issues when they existed were only being identified as "low key" due to the lack of investigative tools being used during examinations. This provided the reasoning and impetus behind developing tools to determine the true extent of oral health conditions in the koala. A suitable assessment tool for diagnosing the oral health was designed based on the index scoring methodology and the layout of the Moggill Koala Hospital admission chart, a new oral health chart template was developed. The chart was based on examination of 30 "free-range koalas" and validation and quality assurance analysis of four examiners of varying qualifications. The chart was separated into three sections; containing general animal information such as sex, age, and current systemic health; the General Oral Cavity section and containing information on 12 koala-specific health questions and finally a section on the periodontal health. The charting data is multifunctional with analysis of individual koalas, (sex, group or age). The data from each section provided an index value that was compatible with values from other species clinical charting systems.Using the chart, populations of 200 "free-range" and 95 captive koalas (from three zoos) were examined. Three major indexes were developed during the chart development process and used the following equation; General Oral Cavity (GOCI) + Oral Health Index (OHI) = Final Oral Health Index (FOHI). Initially, the three major index values plus all additional information of each chart were analysed to show the current baseline values of oral health conditions in the koala. Any ii comparison based on singular or multiple animals would either show a decline, same rate or increase from the baseline. These baseline parameters could be compared against any other species that uses the same 0-3 index system.The proportion of koalas from the whole population with an orally related problem was 86%.The average FOHI for the koala as a species was 3.78 ± 3.19, median 3.00. This is the mild category and held 84.5% of all cases. The maximum scores for the groups showed Zoo 3 as having lower range (Zoo 1; 11.42 for a TWC 1 male, Zoo 2; 13.40, Zoo 3; 4.13 and "free-range"; 15.98). The third zoo was the only group to have also had significantly better oral health than "free-range" koalas.Captive koalas showed high scoring at young age (11.42), the "free-range" comparable age score was 3.84. At population level when controlli...

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“…9 One study showed that 40% of American skulls had at least one dehiscence, with 67% of dehiscences in the mandible. 10 Mostofa et al 11 performed anterior mandibular flaps and CBCTs on 32 patients. Seventy-eight percent of patients had at least one dehiscence, and the highest rates were seen on the canines.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of dehiscences using cone beam computed tomography

Ising

Kim

Araújo

et al. 2011

The Angle Orthodontist

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Objective: To validate the use of three-dimensional (3-D) surface rendering (SR) images to quantify the height of alveolar dehiscences. Materials and Methods: Twenty-four dehiscences were created on 9 incisors, 9 canines, and 6 premolars on 4 cadaver skulls. i-CAT cone beam computed tomography scans (CBCTs) were taken of each skull at .2 mm voxel size. Each dehiscence was quantified by 21 orthodontic residents using 3-D SR. The principal investigator (PI) also quantified each dehiscence using the 2-D multiplanar (MP) image and the 3-D SR image. Results: Results of this study showed an average method error of the residents as a group to be 0.57 mm with an intraclass correlation (ICC) of 0.77%. Residents' method error ranged from 0.45 mm to 1.32 mm, and the ICC ranged from 0.201% to 0.857%. Systematic error was low at 20.01 mm for the direct measurement compared with the residents' average 3-D SR at 1365 density value (DV) measurement. The 3-D SR at 1365 DV images were compared with the MP and 3-D SR images at 1200 DV, and no significant differences in measurements and low systematic error were noted. The method error of the PI was 0.45 mm, 0.45 mm, and 0.41 mm for 3-D SR at 1365 DV, 3-D SR at 1200 DV, and 2-D MP, respectively. Conclusions: 3-D SR and 2D MRP can be used to measure dehiscences of the periodontium with similar levels of accuracy. (Angle Orthod. 2012;82:122-130.)

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Prevalence of Dehiscences and Fenestrations in Modern American Skulls

Cited by 116 publications

References 15 publications

Effect of micro-nano-hybrid structured hydroxyapatite bioceramics on osteogenic and cementogenic differentiation of human periodontal ligament stem cell via Wnt signaling pathway

Effect of micro-nano-hybrid structured hydroxyapatite bioceramics on osteogenic and cementogenic differentiation of human periodontal ligament stem cell via Wnt signaling pathway

Oral health in South East Queensland Koalas: Prevalence of periodontal disease and other pathologies

Evaluation of dehiscences using cone beam computed tomography

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