Purpose: This study investigated the prevalence of postpartum depression (PPD) and explored associatedfactors among mothers attending postnatal care in Bhutan.Methods: A cross-sectional study was conducted from August to November 2023 at a national referralhospital in Thimphu, the capital city of Bhutan. In total, 314 mothers were recruited. Sociodemographic,psychosocial, obstetric, and infant-related data were collected using questionnaires. TheEdinburgh Postnatal Depression Scale, with a threshold of ≥11, was employed to screen for PPD,and logistic regression was used to test the potential factors.Results: The prevalence of PPD was 14.97%. Mothers with a perceived change in body image (adjustedodds ratio [AOR], 4.40; 95% confidence interval [CI], 1.91–10.17; p=.001), perceivedheightened stress after delivery (AOR, 3.74; 95% CI, 1.45–9.67; p=.006), poor relationship with inlaws(AOR, 2.57; 95% CI, 1.24–5.30; p=. 011), and negative birth experience (AOR, 2.42; 95% CI,1.17–5.00; p=.016) demonstrated significantly higher odds of developing PPD. However, motherswith a higher monthly family income (Bhutanese ngultrum [Nu.] 20,000 to <50,000; AOR, 0.35;95% CI, 0.13–0.92; p=.033), ≥Nu. 50,000 (AOR, 0.37; 95% CI, 0.13–1.07, p=.067) compared to<Nu. 20,000, and advanced gestational age (37 to <41 weeks; AOR, 0.25; 95% CI, 0.09–0.71;p=.009) and ≥41 weeks (AOR, 0.08; 95% CI, 0.00–0.75; p=.028) compared to <37 weeks had significantlylower risks of PPD.Conclusion: To mitigate the prevalence and risk of PPD, prioritizing screening strategies and interventionsmay benefit mothers with perceived changes in body image and heightened perceivedstress after delivery, poor relationships with in-laws, and those with negative birth experiences.