Prevalence of depression and its relationship with other clinical characteristics in a sample of patients with stable schizophrenia

Majadas, S.; Olivares, J.M.; Galan, J.; Díez, Teresa

doi:10.1016/j.comppsych.2011.03.009

Cited by 96 publications

(67 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Second, patients in this study seemed to have lower scores of both negative and positive symptoms than some previous studies (eg, Darwish et al, 2011;Majadas et al, 2012;Rabany et al, 2011). The most likely explanation is that patients who were severely impaired could not perform the computerized tasks.…”

Section: Discussioncontrasting

confidence: 51%

Evidence of IQ-Modulated Association Between ZNF804A Gene Polymorphism and Cognitive Function in Schizophrenia Patients

Chen

Zhai

et al. 2012

Neuropsychopharmacol

View full text Add to dashboard Cite

ZNF804A gene polymorphism rs1344706 has been suggested as the most compelling case of a candidate gene for schizophrenia by a genome-wide association study and several replication studies. The current study of 570 schizophrenia patients and 448 controls again found significantly different genotype frequencies of rs1344706 between patients and controls. More important, we found that this association was modulated by IQ, with a stronger association among individuals with relatively high IQ, which replicated results of Walters et al, 2010. We further examined whether this IQ-modulated association also existed between the SNP and the intermediate phenotypes (working memory and executive functions) of schizophrenia. Data were available from an N-back task (366 patients and 414 controls) and the attention network task (361 patients and 416 controls). We found that the SNP and IQ had significant interaction effects on the intermediate phenotypes for patients, but not for controls. The disease risk allele was associated with poorer cognitive function in patients with high IQ, but better cognitive function in patients with low IQ. Together, these results indicated that IQ may modulate the role of rs1344706 in the etiology of both schizophrenia and its cognitive impairments, and pointed to the necessity of considering general cognitive function as indexed by IQ in the future studies of genetic bases of schizophrenia.

show abstract

Section: Discussioncontrasting

confidence: 51%

Evidence of IQ-Modulated Association Between ZNF804A Gene Polymorphism and Cognitive Function in Schizophrenia Patients

Chen

Zhai

et al. 2012

Neuropsychopharmacol

View full text Add to dashboard Cite

show abstract

“…58 Moreover, in cross-sectional evaluations, it may be difficult to distinguish between MDD with psychotic features from schizoaffective disorder, commonly seen as an intermediate condition between major mood disorders and schizophrenia 114 and from schizophrenia, which frequently present with clinically relevant depressive symptoms. 115 Such porosity of the borders between mood disorders and schizophrenia-related disorders is highly likely to add variability to findings from neuroimaging studies of MDD with psychotic features. Future longitudinal neuroimaging investigations with repeated diagnostic assessments over several years of follow-up in representative samples may be needed in order to minimize diagnostic uncertainties and validate the ascertainment of cases to separate categories.…”

Section: Diagnostic Difficulties and Clinical Issues In Neuroimaging mentioning

confidence: 99%

Structural and Functional Neuroimaging Studies in Major Depressive Disorder With Psychotic Features: A Critical Review

Busatto

2013

Schizophrenia Bulletin

View full text Add to dashboard Cite

The relationship between major depressive disorder with psychotic (MDDP) features and schizophrenia has long been recognized, and the neurobiological boundaries between these disorders can nowadays be investigated using neuroimaging techniques. This article provides a critical review of such studies, addressing how they support a dimensional approach to the nosology and pathophysiology of psychotic disorders. A proportion of neuroimaging studies carried out to date indicate that MDDP subjects display structural and functional abnormalities in some brain regions specifically implicated in the pathophysiology of mood disorders, such as the subgenual cingulate cortex. This reinforces the validity of the classification of MDDP in proximity to major depression without psychosis. There is some neuroimaging evidence that MDDP may be associated with additional brain abnormalities relative to nonpsychotic major depression although less prominently in comparison with findings from the neuroimaging literature on schizophrenia. Brain regions seen as critical both to emotional processing and to models of psychotic symptoms, such as the hippocampus, insula, and lateral prefrontal cortex, have been implicated in separate neuroimaging investigations of either schizophrenia or major depression, as well as in some studies that directly compared depressed patients with and without psychotic features. These brain regions are key targets for future studies designed to validate imaging phenotypes more firmly associated with MDDP, as well as to investigate the relationship between these phenotypes and possible etiological influences for MDDP.

show abstract

“…Наличие депрессивных симптомов у пациентов с шизофренией связано с общим ухудшением прогноза, большей коморбидностью, снижением качества жизни и социального функ-ционирования, более высоким риском рецидива и суи цида [8,23,34]. В современной литературе нет единой точки зрения о терапевтических подхо-дах у пациентов с депрессией в структуре обостре-ния шизофрении, добавление антидепрессантов к базовой терапии большинство исследователей ставят под сомнение.…”

Section: резюмеunclassified

Cortisol and BDNF levels in depression within schizophrenia structure: approach to treating

Nikiforova

Мазо

2016

Rev Clin Pharm Drug Ther

View full text Add to dashboard Cite

To evaluate the effect of depression on the level of cortisol and BDNF in patients with schizophrenia 25 inpatients, who met the diagnostic criteria for ICD-10 schizophrenia (F20), were examined. The examination included clinical, psychopathological, laboratory and psychometric methods. Patients were examined twice: at admission and after 6 weeks of treatment. It was found that the level of BDNF in schizophrenic patients with depressive symptoms was significantly lower than that of non-depressed patients, and the level of cortisol in patients with depression was significantly higher.

show abstract

Prevalence of depression and its relationship with other clinical characteristics in a sample of patients with stable schizophrenia

Cited by 96 publications

References 47 publications

Evidence of IQ-Modulated Association Between ZNF804A Gene Polymorphism and Cognitive Function in Schizophrenia Patients

Evidence of IQ-Modulated Association Between ZNF804A Gene Polymorphism and Cognitive Function in Schizophrenia Patients

Structural and Functional Neuroimaging Studies in Major Depressive Disorder With Psychotic Features: A Critical Review

Cortisol and BDNF levels in depression within schizophrenia structure: approach to treating

Contact Info

Product

Resources

About