Prevalence of depression, anxiety, and adjustment disorder in oncological, haematological, and palliative-care settings: a meta-analysis of 94 interview-based studies

Mitchell, Alex J.; Chan, Melissa; Bhatti, Henna; Halton, Marie; Grassi, Luigi; Johansen, Christoffer; Meader, Nick

doi:10.1016/s1470-2045(11)70002-x

Cited by 2,005 publications

(1,570 citation statements)

References 118 publications

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“…2007; Mitchell et al. 2011). Anxiety symptoms tended to persist post‐disease if present before disease onset (Sawyer et al.…”

Section: Discussionmentioning

confidence: 99%

“…in fibromyalgia Dawson 2014 Search: Feb 2012 # incl. studies 16 Meta‐analysis: no Adults with age‐related macular degeneration (AMD) age 18 + Range: 51–32,702 Recruited from eye clinics, GP clinics Clinical/specialist setting Western studies, many US Almost all symptom checklists, structured clinical interviewGenerally no link with anxiety found, but one study reported prev of 30.1% in AMD Other chronic physical diseases in end‐stage Mitchell 2011 Search: Nov. 2010 # incl. studies 94 Meta‐analysis: yes 4007 adults age 18 + in palliative care; 10,071 adults 18 + in palliative care and oncological settings Patients from oncological, hematological, and palliative‐care settings Mostly Western studies Psychiatric interviews9.8% (6.8–13.2) in palliative‐care, and 10.3% (5.1–17.0) in oncological and hematological settingsJanssen 2008 – previously described Murtagh 2007 Search: April 2005 # incl.…”

Section: Embasementioning

confidence: 99%

“…studies 24 Meta‐analysis: no Original studies Different recruitment methods, study inclusion criteria Most study patients were women, thus, possible overestimation of significance of results Different measurement methods: questionnaires, clinical evaluations, structured interviews (some methods not validated for pain patients) Review Search strategy 6 Dawson 2014 Search: Feb 2012 # incl. studies 16 Meta‐analysis: no Does anxiety come before onset of AMD? Link between length of time since AMD diagnosis and AMD treatments in relation to patient's mental health Include control group to compare prev of anxiety between AMD and non‐AMD populations Use tools with clear cut‐off for clinical anxiety Original studies Is anxiety different in different forms of AMD? Different definition and measurement of anxiety Comparison group may not be representative Review Small number of studies 5 Other chronic physical diseases in end‐stage Mitchell 2011 Search: Nov. 2010 # incl. studies 94 Meta‐analysis: yes Original studies No consensus about optimum psychiatric diagnostic approach in cancer settings Studies of variable quality, mostly cross‐sectional designs, some used convenience sampling, different anxiety measurement methods Could not determine correlates of anxiety Few studies with defined period of prevalence Review Possible publication bias 8Janssen 2008 – previously described Murtagh 2007 Search: April 2005 # incl.…”

Section: Embasementioning

confidence: 99%

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A systematic review of reviews on the prevalence of anxiety disorders in adult populations

et al. 2016

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BackgroundA fragmented research field exists on the prevalence of anxiety disorders. Here, we present the results of a systematic review of reviews on this topic. We included the highest quality studies to inform practice and policy on this issue.MethodUsing PRISMA methodology, extensive electronic and manual citation searches were performed to identify relevant reviews. Screening, data extraction, and quality assessment were undertaken by two reviewers. Inclusion criteria consisted of systematic reviews or meta‐analyses on the prevalence of anxiety disorders that fulfilled at least half of the AMSTAR quality criteria.ResultsWe identified a total of 48 reviews and described the prevalence of anxiety across population subgroups and settings, as reported by these studies. Despite the high heterogeneity of prevalence estimates across primary studies, there was emerging and compelling evidence of substantial prevalence of anxiety disorders generally (3.8–25%), and particularly in women (5.2–8.7%); young adults (2.5–9.1%); people with chronic diseases (1.4–70%); and individuals from Euro/Anglo cultures (3.8–10.4%) versus individuals from Indo/Asian (2.8%), African (4.4%), Central/Eastern European (3.2%), North African/Middle Eastern (4.9%), and Ibero/Latin cultures (6.2%).ConclusionsThe prevalence of anxiety disorders is high in population subgroups across the globe. Recent research has expanded its focus to Asian countries, an increasingly greater number of physical and psychiatric conditions, and traumatic events associated with anxiety. Further research on illness trajectories and anxiety levels pre‐ and post‐treatment is needed. Few studies have been conducted in developing and under‐developed parts of the world and have little representation in the global literature.

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“…2007; Mitchell et al. 2011). Anxiety symptoms tended to persist post‐disease if present before disease onset (Sawyer et al.…”

Section: Discussionmentioning

confidence: 99%

Section: Embasementioning

confidence: 99%

Section: Embasementioning

confidence: 99%

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A systematic review of reviews on the prevalence of anxiety disorders in adult populations

et al. 2016

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“…In one study, from 9% to 27% of TC survivors presented with anxiety or depression [34]. In a meta-analysis of mood disorder prevalence in cancer settings, there was less interviewer-defined depression and anxiety than anticipated in cancer patients, although a combination of various mood disorders occurred in 30-40% of hospitalized cancer patients [35]. In a study of long-term distress in a sub-set of men with BRCA1/2 mutations, predictors of distress included higher baseline distress and being unmarried [15], whereas, most of our distressed participants were married and all but one were affected with TC.…”

Section: Discussionmentioning

confidence: 99%

Close ties: an exploratory Colored Eco-Genetic Relationship Map (CEGRM) study of social connections of men in Familial Testicular Cancer (FTC) families

Peters

Kenen

Hoskins

et al. 2012

Hered Cancer Clin Pract

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BackgroundTesticular cancer, while rare compared with other adult solid tumors, is the most common cancer in young men in northern Europe and North America. Risk factors include white race, positive family history, contralateral testicular cancer, cryptorchidism, infertility and testicular microlithiasis. As the genetic causes of familial clusters (Familial Testicular Cancer or FTC) are being sought, it is also important to understand the psycho-social experiences of members of FTC families.MethodsThis is a cross-sectional examination via the Colored Eco-Genetic Relationship Map (CEGRM) of social connections reported by 49 men in FTC families participating in NCI research study 02-C-178.ResultsThe CEGRM was acceptable and feasible for use with men in FTC families, and valuable in understanding their social connections. These men have largely adjusted to the TC history in themselves and/or their relatives. They have considerable social and emotional support from family and friends, although there is wide variability in sources and types.ConclusionsThe CEGRM focuses on men's social connections and close emotional bonds in FTC families. This action-oriented process of placing colored symbols on significant relationships uncovered previously under-appreciated emotions accompanying men's social exchanges. Most men in FTC families succeed in re-establishing a sense of normalcy in their lives and social connections, in the aftermath of a testicular cancer diagnosis.

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“…1,6,32,44 Finally, given the often significant overlap between depression symptoms and other outcomes (such as distress, anxiety, fatigue, and pain), multidimensional assessment might also be more useful than focusing on the single construct of depression. 4,8,15,61,62 In practice, clinicians are rarely solely interested in depression, potentially limiting the relevance of this meta-review to clinical practice. 56 However, assessment of multiple dimensions within one measure can create statistical and clinical challenges in interpreting the data, 63 suggesting that there still is a role for depression-specific measurement when it is the primary focus of a research project.…”

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confidence: 99%

Patient-reported depression measures in cancer: a meta-review

Wakefield

Butow

Aaronson

et al. 2015

The Lancet Psychiatry

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SummaryDepression measurement in cancer care is complex and inconsistent. It is difficult for investigators to select the best-performing tool. We conducted a meta-review to integrate the findings of reviews of patient-report depression measures used as screeners or case-finders in oncology. We searched Medline, PsycINFO, EMBASE and grey literature from 1999-2014. We identified 19 reviews representing 372 primary studies assessing more than 50 depression measures. We used 11 highquality reviews to guide our analysis, which was organized by measurement goal and target population. The Hospital Anxiety Depression Scale was the most recommended, and criticized, depression screener. Few reviews evaluated casefinding performance or measure responsiveness, or measure suitability for particular populations. This meta-review demonstrates that the available measure selection advice is conflicting. By being fully cognizant of the benefits and limitations of depression measurement, investigators can improve the accuracy of their data and achieve more sophisticated interpretations of their findings.

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Prevalence of depression, anxiety, and adjustment disorder in oncological, haematological, and palliative-care settings: a meta-analysis of 94 interview-based studies

Cited by 2,005 publications

References 118 publications

A systematic review of reviews on the prevalence of anxiety disorders in adult populations

A systematic review of reviews on the prevalence of anxiety disorders in adult populations

Close ties: an exploratory Colored Eco-Genetic Relationship Map (CEGRM) study of social connections of men in Familial Testicular Cancer (FTC) families

Patient-reported depression measures in cancer: a meta-review

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