Prevalence of Depression in Patients With Mild Cognitive Impairment

Ismail, Zahinoor; Elbayoumi, Heba; Fischer, Corinne E.; Hogan, David B.; Millikin, Colleen; Schweizer, Tom A.; Mortby, Moyra E.; Smith, Eric E.; Patten, Scott B.; Fiest, Kirsten M.

doi:10.1001/jamapsychiatry.2016.3162

Cited by 403 publications

(301 citation statements)

References 109 publications

Supporting

Mentioning

262

Contrasting

Unclassified

Order By: Relevance

“…As expected, those with MCI and dementia reported the highest prevalence of NPS (53.4% and 80%, respectively). This is consistent with previous reports of NPS in community-based samples of clinical groups, where NPS have been reported in 61%-97% of individuals with dementia [7,8] and 31%-50% of individuals with MCI [4][5][6]8]. These finding are or particular clinical relevance as it is well accepted that the comorbid presentation of NPS in MCI is linked to higher progression to dementia and that for patients with AD, NPS are associated with an increased likelihood of progression from mild to severe dementia [35].…”

Section: Prevalence Of Npssupporting

confidence: 93%

“…Prevalence estimates of NPS are reported among 31%-50% of individuals with MCI [4][5][6] and 61%-97% of individuals with dementia [7,8]. It is well accepted that the comorbid presentation of NPS in MCI is linked to higher progression to dementia [9][10][11][12][13][14][15] and that for patients with Alzheimer's disease (AD), NPS are associated with an increased likelihood of progression from mild to severe dementia [16].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Neuropsychiatric Symptoms and Cognitive Impairment: Understanding the Importance of Co-Morbid Symptoms

Mortby

Burns

Eramudugolla

et al. 2017

JAD

Self Cite

View full text Add to dashboard Cite

Abstract.Background: Neuropsychiatric symptoms (NPS) are common in older adults with cognitive impairment, yet little is known about population-based prevalence and clinical implications of co-morbid symptom presentation across the spectrum from normal cognition to dementia. Objective: To characterize the prevalence of NPS and explore the clinical implications of co-morbid symptom presentation. Methods: Cross-sectional study of 1,417 older adults (aged 73-79) with dementia (n = 40); with mild cognitive impairment (MCI; n = 133); who are 'cognitively normal, but-at-risk' (CN-AR; n = 397); and who are cognitively normal (n = 847). NPS were assessed by the Neuropsychiatric Inventory. Cluster analyses were conducted using a latent class analysis (LCA). Results: NPS are highly prevalent across the cognitive function spectrum (30.8%-80%). NPS were associated with a 3-fold increased risk of dementia, a 2-fold increased risk of MCI, and a 1.5-times increased risk of CN-AR. Each additional co-morbid symptom was associated with an additional 1.5-times increased risk of dementia, but not MCI or CN-AR. LCA revealed four distinctive sub-populations: 1) frontal/low comorbidity; 2) high prevalence/high comorbidity; 3) affective/low comorbidity; and 4) sleep/low comorbidity. Conclusion: Our findings confirm previous reports on the prevalence of NPS in community-based samples and are consistent with the profiles of NPS domain characteristics of MCI and dementia. Number of co-morbid NPS and not symptom clusters are associated with increased risk of dementia. Understanding such patterns will help inform our understanding of mild behavioral disorders and assist with clinical assessment.

show abstract

Section: Prevalence Of Npssupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Neuropsychiatric Symptoms and Cognitive Impairment: Understanding the Importance of Co-Morbid Symptoms

Mortby

Burns

Eramudugolla

et al. 2017

JAD

Self Cite

View full text Add to dashboard Cite

show abstract

“…1 Around half of those diagnosed with MCI will develop dementia within 3 years, and from the point of MCI diagnosis, 6% to 15% of patients will convert to dementia per year. 8,9 Nonetheless, the modifiable risk factors identified by Cooper et al are pathologies in their own right, with effective treatments available in primary care. Furthermore, a recent meta-analysis has shown that there are some modifiable predictors of conversion to dementia, including untreated diabetes and low dietary folate (with the caveat that there is currently no prospective evidence proving that modifying these risk factors reduces the risk of progressing to dementia, with the possible exception of folate supplementation).…”

Section: Introductionmentioning

confidence: 99%

Cognitive tests for the detection of mild cognitive impairment (MCI), the prodromal stage of dementia: Meta‐analysis of diagnostic accuracy studies

Breton

Casey

Arnaoutoglou

2018

Int J Geriat Psychiatry

209

134

View full text Add to dashboard Cite

Introduction Mild cognitive impairment (MCI) is regarded as a prodrome to dementia. Various cognitive tests can help with diagnosis; meta‐analysis of diagnostic accuracy studies would assist clinicians in choosing optimal tests. Methods We searched online databases for “mild cognitive impairment” and “diagnosis” or “screening” from 01/01/1999 to 01/07/2017. Articles assessing the diagnostic accuracy of a cognitive test compared with standard diagnostic criteria were extracted. Risk of bias was assessed. Bivariate random‐effects meta‐analysis was used to evaluate sensitivity and specificity. Results Eight cognitive tests (ACE‐R, CERAD, CDT‐Sunderland, IQCODE, Memory Alteration Test, MMSE, MoCA, and Qmci) were considered for meta‐analysis. ACE‐R, CERAD, MoCA, and Qmci were found to have similar diagnostic accuracy, while the MMSE had lower sensitivity. Memory Alteration Test had the highest sensitivity and equivalent specificity to the other tests. Discussion Multiple cognitive tests have comparable diagnostic accuracy. The Memory Alteration Test is short and has the highest sensitivity. New cognitive tests for MCI diagnosis should not be compared with the MMSE.

show abstract

“…NPS have been described in 79.5% of adults with MCI with worsening cognitive decline while depression was the most common manifestation 39. The overall prevalence of depression has been reported to occur in 32% of patients with MCI 40. The prevalence of anxiety among patients with MCI ranged from 14.3% to 31.2% 41.…”

Section: Definitions and Diagnostic Criteriamentioning

confidence: 99%

Mild cognitive impairment in primary care: a clinical review

Assaf

Tanielian

2018

Postgraduate Medical Journal

View full text Add to dashboard Cite

Dementia is projected to become a global health priority but often not diagnosed in its earlier preclinical stage which is mild cognitive impairment (MCI). MCI is generally referred as a transition state between normal cognition and Alzheimer’s disease. Primary care physicians play an important role in its early diagnosis and identification of patients most likely to progress to Alzheimer’s disease while offering evidenced-based interventions that may reverse or halt the progression to further cognitive impairment. The aim of this review is to introduce the concept of MCI in primary care through a case-based clinical review. We discuss the case of a patient with MCI and provide an evidence-based framework for assessment, early recognition and management of MCI while addressing associated risk factors, neuropsychiatric symptoms and prognosis.

show abstract

Prevalence of Depression in Patients With Mild Cognitive Impairment

Abstract: The prevalence of depression in patients with MCI is high. A contributor to heterogeneity in the reported literature is the source of the sample, with greater depression burden prevalent in clinic-based samples.

Cited by 403 publications

References 109 publications

Neuropsychiatric Symptoms and Cognitive Impairment: Understanding the Importance of Co-Morbid Symptoms

Neuropsychiatric Symptoms and Cognitive Impairment: Understanding the Importance of Co-Morbid Symptoms

Cognitive tests for the detection of mild cognitive impairment (MCI), the prodromal stage of dementia: Meta‐analysis of diagnostic accuracy studies

Mild cognitive impairment in primary care: a clinical review

Contact Info

Product

Resources

About