Prevalence of depression in type 2 diabetes mellitus

Calvín, J.L. Rodríguez; Gaviria, A. Zapatero; Ríos, María Dolores Martín

doi:10.1016/j.rceng.2014.12.001

Cited by 15 publications

(4 citation statements)

References 22 publications

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“…Studies have shown that these same individuals were less likely to (30,31), raising the possibility that the co-occurrence of depressive symptoms might adversely affect self-management and glycemic control. In line with previous reports (32,33), this analysis found older age was associated with depressive symptoms, especially in patients with type 2 diabetes treated with OGLDs only. That said, older patients do not always present with the typical depressive symptoms, which may hinder the diagnosis of depression (34).…”

Section: Discussionsupporting

confidence: 93%

High Prevalence of Depressive Symptoms in Patients With Type 1 and Type 2 Diabetes in Developing Countries: Results From the International Diabetes Management Practices Study

et al. 2020

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Depression is common in people with diabetes, but data from developing countries are scarce. We evaluated the prevalence and risk factors for depressive symptoms in patients with diabetes using data from the International Diabetes Management Practices Study (IDMPS). RESEARCH DESIGN AND METHODSIDMPS is an ongoing multinational, cross-sectional study investigating quality of care in patients with diabetes in real-world settings. Data from wave 5 (2011), including 21 countries, were analyzed using the 9-item Patient Health Questionnaire (PHQ-9) to evaluate depressive symptoms. Logistic regression analyses were conducted to identify risk factors of depressive symptoms. RESULTSOf 9,865 patients eligible for analysis, 2,280 had type 1 and 7,585 had type 2 diabetes (treatment: oral glucose-lowering drugs [OGLD] only, n 5 4,729; OGLDs plus insulin, n 5 1,892; insulin only, n 5 964). Depressive symptoms (PHQ-9 score $5) were reported in 30.7% of those with type 1 diabetes. In patients with type 2 diabetes, the respective figures were 29.0% for OGLDs-only, 36.6% for OGLDs-plus-insulin, and 46.7% for insulin-only subgroups. Moderate depressive symptoms (PHQ-9 score 10-19) were observed in 8-16% of patients with type 1 or type 2 diabetes. Female sex, complications, and low socioeconomic status were independently associated with depressive symptoms. In type 1 diabetes and in the type 2 diabetes OGLDs-only group, depression was associated with poor glycemic control. CONCLUSIONSDepressive symptoms are common in patients with diabetes from developing countries, calling for routine screening, especially in high-risk groups, to reduce the double burden of diabetes and depression and their negative interaction.

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Section: Discussionsupporting

confidence: 93%

High Prevalence of Depressive Symptoms in Patients With Type 1 and Type 2 Diabetes in Developing Countries: Results From the International Diabetes Management Practices Study

et al. 2020

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“…Recently, an association between T2DM and depression has been reported in several studies with a cross‐sectional design . The prevalence of depression in patients with T2DM tend to be low in East Asia compared to Europe and the US (China 6.1%; UK 9.3%; US 10.6%; Spain 32.7%).…”

Section: Introductionmentioning

confidence: 98%

“…[8][9][10][11] Recently, an association between T2DM and depression has been reported in several studies with a cross-sectional design. [12][13][14] The prevalence of depression in patients with T2DM tend to be low in East Asia compared to Europe and the US (China 6.1%; UK 9.3%; US 10.6%; Spain 32.7%). Additionally, in each country, the prevalence of depression in female patients is larger than male patients.…”

mentioning

confidence: 99%

Association between use of oral hypoglycemic agents in Japanese patients with type 2 diabetes mellitus and risk of depression: A retrospective cohort study

Akimoto

Tezuka

Nishida

et al. 2019

Pharmacology Res & Perspec

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Type 2 diabetes mellitus (T2DM) is a risk factor for depression. Since brain insulin resistance plays a potential role in depression, the future risk of depression in patients with T2DM may be altered depending on the class of oral hypoglycemic agent (OHA) used for T2DM therapy. The aim of the present study was to determine if specific classes of OHAs are associated with a risk for comorbid depression in T2DM. Japanese adult patients with T2DM (n = 40 214) were divided into a case group (with depression; n = 1979) and control group (without depression; n = 38 235). After adjustment for age [adjusted odds ratio (AOR) for 10 years: 1.03; 95% confidence interval (CI): 0.99‐1.07; P = .1211], sex [AOR for female: 1.39; 95% CI: 1.26‐1.53; P < .0001], hemoglobin A1c [AOR for 1.0%: 1.18; 95% CI: 1.11‐1.26; P < .0001], duration of T2DM [AOR for 1 year: 1.00; 95% CI: 0.99‐1.01; P = .4089], and history of seven medical conditions, the odds ratios for the development of depression was significantly lower for dipeptidyl peptidase‐4 (DPP‐4) inhibitors [AOR: 0.31; 95% CI: 0.24‐0.42; P < .0001]. However, there was no significant association for the other classes of OHAs. Therefore, this study finds that there is less risk of depression associated with the use of DPP‐4 inhibitors for the treatment of T2DM.

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“…For example, the association between depression and type 2 diabetes (T2DM) has been recognized for many years. One epidemiological study suggested that at least one-third of people with diabetes suffer from clinically relevant depressive disorders (3). A meta-analysis of 11 studies reported a 24% increased risk of incident depression in people with T2DM, compared to those without T2DM (4).…”

Section: Introductionmentioning

confidence: 99%

Adding Pay-for-Performance Program to Routine Care Was Related to a Lower Risk of Depression Among Type 2 Diabetes Patients in Taiwan

Lian

Livneh

Huang

et al. 2021

Front. Public Health

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Background: Patients with type 2 diabetes (T2DM) often experience depression during treatment, negatively influencing their treatment compliance and clinical outcomes. Recently, the pay-for-performance (P4P) program for chronic diseases, with high-cost and high-risk feature, such as T2DM, has been implemented and has been operational for several years. Nevertheless, its effect on the risk of developing depression among T2DM cases is unknown. This study aims to explore the association of P4P use with the subsequent risk of developing depression among these patients.Methods: This cohort study used a nationwide health insurance database to identify patients 20–70 years of age newly diagnosed with T2DM who enrolled in the P4P program between 2001 and 2010. From this group, we enrolled 17,022 P4P users and then 17,022 non-P4P users who were randomly selected using propensity-score–matching. Enrolled patients were followed until the end of 2012 to record the occurrence of depression. The Cox proportional hazards regression was utilized to obtain the adjusted hazard ratio (aHR) for P4P use.Results: During the study period, a total of 588 P4P users and 1,075 non-P4P users developed depression at incidence rates of 5.89 and 8.41 per 1,000 person-years, respectively. P4P users had a lower depression risk than did non-P4P users (aHR, 0.73; 95% Confidence Interval, 0.65–0.80). This positive effect was particularly prominent in those receiving high-intensity use of the P4P program.Conclusion: Integrating P4P into routine care for patients with T2DM may have beneficial effects on curtailing the subsequent risk of depression.

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Prevalence of depression in type 2 diabetes mellitus

Cited by 15 publications

References 22 publications

High Prevalence of Depressive Symptoms in Patients With Type 1 and Type 2 Diabetes in Developing Countries: Results From the International Diabetes Management Practices Study

High Prevalence of Depressive Symptoms in Patients With Type 1 and Type 2 Diabetes in Developing Countries: Results From the International Diabetes Management Practices Study

Association between use of oral hypoglycemic agents in Japanese patients with type 2 diabetes mellitus and risk of depression: A retrospective cohort study

Adding Pay-for-Performance Program to Routine Care Was Related to a Lower Risk of Depression Among Type 2 Diabetes Patients in Taiwan

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