Prevalence of diabetes across different immigrant groups in North-eastern Italy

Fedeli, Ugo; Casotto, Veronica; Ferroni, Eliana; Saugo, Mario; Targher, G.; Zoppini, Giacomo

doi:10.1016/j.numecd.2015.06.010

Cited by 16 publications

(11 citation statements)

References 27 publications

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“…This is true also for T2D; its prevalence in migrants is high [13,14], but again ethnic differences are relevant [12], with this disease being more frequent in people of South Asian, African and African-Caribbean family origin [5,15]. T2D is more likely to be poorly controlled in migrants [16], and can be less intensely treated in migrants than in natives [17]. This picture is made even more complicated by the fact that the information on NCD and their treatment in migrants is mainly obtained in documented migrants, for whom electronic health records are available.…”

Section: Introductionmentioning

confidence: 99%

Current Pharmacological Treatment of Type 2 Diabetes Mellitus in Undocumented Migrants: Is It Appropriate for the Phenotype of the Disease?

Fiorini

Cortinovis

Corrao

et al. 2020

IJERPH

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Type 2 diabetes is increasingly recognized as a spectrum of metabolic disorders sharing chronic hyperglycaemia. In Europe, the continually growing number of migrants from developing countries could affect diabetes phenotypes. We evaluated a population of 426 Italians and 412 undocumented migrants. Using 17 variables (with the exclusion of ethnic origin) we performed a multiple component analysis to detect potential clusters, independently from ethnicity. We also compared the two groups to evaluate potential ethnicity associated differences. We found five clusters of patients with different disease phenotypes. Comparing Italians with undocumented migrants, we noted that the first had more often cardiovascular risk factors and neurologic involvement, while the latter had a higher frequency of diabetic ulcers and renal involvement. Metformin was used in a comparable percentage of patients in all clusters, but other antidiabetic treatments showed some differences. Italians were more often on insulin, due to a larger use of long acting insulin, and received a larger number of oral antidiabetics in combination. Pharmacological treatment of comorbidities showed some differences too. We suggest that type 2 diabetes should be considered as a spectrum of diseases with different phenotypes also in heterogeneous populations, and that this is not due only to ethnic differences.

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Section: Introductionmentioning

confidence: 99%

Current Pharmacological Treatment of Type 2 Diabetes Mellitus in Undocumented Migrants: Is It Appropriate for the Phenotype of the Disease?

Fiorini

Cortinovis

Corrao

et al. 2020

IJERPH

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“…The burden of type 2 diabetes (T2D) differs greatly across ethnic groups living in the same geographical location . Disparities were for instance observed between groups of Dutch, Ghanaian, Turkish, Moroccan, South‐Asian Surinamese, and African Surinamese ethnicity living in the Netherlands .…”

Section: Introductionmentioning

confidence: 99%

Plasma Cholesteryl Ester Fatty Acids do not Mediate the Association of Ethnicity with Type 2 Diabetes: Results From the HELIUS Study

Muilwijk

Celis‐Morales

Nicolaou

et al. 2017

Molecular Nutrition Food Res

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“…Our cohort of patients reflected real clinical practice, and the results must be interpreted, taking into account of limitations related to the observational nature of the study, based on data collected through administrative and laboratory databases. Administrative data are not intently gathered for research purpose, nevertheless they represent remarkable resources for healthcare research, by providing a large and representative sample of study population without requiring the 6 Journal of Diabetes Research The analysis was carried out on the cohort of patients for which the laboratory data were available and with at least 3 months of follow-up.^p < 0:05 among groups.°p < 0:05 among groups. 7 Journal of Diabetes Research personal involvement of participants.…”

Section: Discussionmentioning

confidence: 99%

“…Recent epidemiological studies have shown an increasing prevalence of diabetes in Europe and worldwide [4][5][6]. Type 2 diabetes (T2DM) is the most common form of the disease, corresponding to approximately 90% of cases.…”

Section: Introductionmentioning

confidence: 99%

Insulin Glargine U100 Utilization in Patients with Type 2 Diabetes in an Italian Real-World Setting: A Retrospective Study

Esposti

Perrone

Saragoni

et al. 2019

Journal of Diabetes Research

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Background. This study is aimed at estimating the proportion of type 2 diabetes mellitus (T2DM) patients treated with basal insulin (insulin glargine U100) and at evaluating daily insulin dose, treatment pattern, and adherence to treatment of these patients. Methods. Data from administrative and laboratory databases of 3 Italian Local Health Units were retrospectively collected and analyzed. All patients with a diagnosis of T2DM between 01/01/2012 and 31/12/2012 were considered, and those with at least a prescription of insulin glargine between 01/01/2013 and 31/12/2014 were included and followed up for one year. For each patient, we evaluated HbA1c levels both at baseline and during the follow-up period and the daily average dose of insulin. Medication adherence was defined by using medication possession ratio (MPR) and reported as proportion of patients with MPR≥80%. Results. 7,422 T2DM patients were available for the study. According to the antidiabetic medication prescribed, patients were categorized into four groups: insulin glargine only, insulin glargine plus oral glucose-lowering drugs, insulin glargine plus rapid-acting insulin, and insulin glargine plus DPP-4 inhibitors. Median daily dose of insulin among insulin glargine only patients was higher than in other groups (35 IU vs. 20 IU, p<0.05), and a higher percentage of them achieved a target HbA1c value of less than 7.0% (53.8% vs. 30%, p<0.001). Adherence to insulin treatment was lowest (41%) in the insulin glargine only group compared to other groups (ranging from 58.4% to 64.4%), p<0.001. Conclusions. A large proportion of T2DM patients treated with insulin fail in achieving the glycemic target of HbA1c level<7%, irrespective of treatment regimen; however, basal insulin only is associated with lower therapeutic unsuccess. Adherence to antidiabetes medications is also suboptimal in these patients and should be addressed to improve long-term outcomes of reducing and preventing microvascular and macrovascular complications.

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Prevalence of diabetes across different immigrant groups in North-eastern Italy

Cited by 16 publications

References 27 publications

Current Pharmacological Treatment of Type 2 Diabetes Mellitus in Undocumented Migrants: Is It Appropriate for the Phenotype of the Disease?

Current Pharmacological Treatment of Type 2 Diabetes Mellitus in Undocumented Migrants: Is It Appropriate for the Phenotype of the Disease?

Plasma Cholesteryl Ester Fatty Acids do not Mediate the Association of Ethnicity with Type 2 Diabetes: Results From the HELIUS Study

Insulin Glargine U100 Utilization in Patients with Type 2 Diabetes in an Italian Real-World Setting: A Retrospective Study

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