Prevalence of Diabetes in Patients with Hyperuricemia and Gout: A Systematic Review and Meta-analysis

Jiang, Jingyi; Zhang, Tingjing; Liu, Yashu; Chang, Qing; Zhao, Yuhong; Guo, Chuanji; Yang, Xia

doi:10.1007/s11892-023-01506-2

Cited by 29 publications

(9 citation statements)

References 57 publications

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“…A meta-analysis encompassed 38 studies, the prevalence of diabetes was observed to be 19.10% in HUA. 35 The observed variation may be attributed to the differences in the selected populations and the smaller number of samples included in our study. One credible hypothesis posits that insulin resistance serves as a shared pathophysiological underpinning for both diabetes and HUA.…”

Section: Discussionmentioning

confidence: 85%

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Fractional Excretion of Urate is Positively Associated with Type 2 Diabetes in HUA Patients: A Cross-Sectional Study

Huang,

Li,

Zhang

et al. 2024

DMSO

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People with hyperuricemia (HUA) are often related to metabolic disorders such as diabetes, metabolic syndrome (MetS), and obesity. However, the correlation between excretion of uric acid and these diseases is unclear. Our study aimed to explore the relationship between uric acid excretion and type 2 diabetes (T2D). Methods: A total of 228 HUA patients from Tianjin Medical University General Hospital from 2022 to 2023 were included in this study. We collected demographic, biochemical, and anthropometric data on each subject. Urine uric acid excretion (UUAE) was calculated enzymatically from a single urine collection that lasted 24 hours. And fractional excretion of uric acid (FEUA) was calculated from serum uric acid and creatinine and uric acid and creatinine. Binary logistic regression modeling assessed the association between uric acid excretion and T2D. Results: Of the 228 subjects, 13.4% had T2D and 48.7% had obesity. The obesity group had a lower FEUA (p<0.05) and a higher UUAE compared to the control group (p<0.05). And FEUA had a stronger correlation with the risk of T2D (p<0.001). Also, there was a negative association between BMI and FEUA and a positive link between BMI and UUAE in the outpatients. Conclusion: Increased FEUA levels were significantly associated with T2D in HUA patients. Therefore, routine calculating of FEUA is essential for proper diagnosis and appropriate treatment T2D of in HUA patients.

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Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 85%

Fractional Excretion of Urate is Positively Associated with Type 2 Diabetes in HUA Patients: A Cross-Sectional Study

Huang,

Li,

Zhang

et al. 2024

DMSO

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“…Under normal conditions, SUA levels range from 1.5 to 6 mg per deciliter for females and 2.5–7 mg per deciliter for males ( Chen et al, 2020 ). Although moderate SUA levels are recognized as beneficial antioxidants, hyperuricemia or excessive SUA levels have been confirmed as independent risk factors for various diseases, including metabolic syndrome, diabetes, hypertension, cardiovascular events, and kidney disorders ( Chen et al, 2022 ; Nishizawa et al, 2022 ; Jiang et al, 2023 ). However, the precise relationship between uric acid levels and psoriasis remains unclear, and there is a scarcity of randomized controlled trial (RCT) studies investigating the impact of uric acid on psoriasis, with only a limited number of experimental and epidemiological studies having explored this association.…”

Section: Introductionmentioning

confidence: 99%

The impact of serum uric acid on psoriasis: NHANES 2005–2014 and Mendelian randomization

Hu,

Wang,

et al. 2024

Front. Genet.

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Background:Psoriasis is a chronic systemic inflammatory disease, and hyperuricemia is a common comorbidity in patients with psoriasis. However, the exact relationship between uric acid levels and psoriasis remains unclear. This study aimed to explore the association between uric acid levels and psoriasis.Methods:Observational study participant data (≥16 years, n = 23,489) from NHANES 2003–2014. We conducted analyses using a weighted multiple logistic regression model. Genetic data sets for uric acid levels and psoriasis were obtained from the IEU database. We selected genetically independent loci closely associated with serum uric acid levels as instrumental variables and performed Mendelian randomization analyses using five complementary methods: inverse variance weighting (IVW), MR-Egger, weighted median, simple mode, and weighted mode.Results:After adjusting for other covariates, the results revealed no significant association between serum uric acid levels and psoriasis (b = 0.999, 95% CI: 0.998, 1.001, p = 0.275). Subgroup analyses stratified by gender and ethnicity showed no significant association between sUA and psoriasis in any of the subgroups. Furthermore, the MR analysis involved the selection of 227 SNPs that were associated with both sUA and psoriasis. IVW results demonstrated no causal relationship between sUA and psoriasis (OR = 0.282, 95% CI: -0.094–0.657, p = 0.142).Conclusion:Our study suggests that uric acid levels are not significantly causally related to psoriasis. This finding provides valuable insights for the treatment and prevention of psoriasis, indicating that merely reducing uric acid levels may not be an effective strategy to reduce the risk of psoriasis onset.

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“…Similar trends have also been observed in many other countries ( 7 , 8 ). The combined prevalence of diabetes among patients with hyperuricemia and gout was 19.00% and 17.80%, respectively ( 9 ). A cross-sectional survey reported that SUA of patients with diabetes was 344.05 ± 90.89 μmol/L ( 10 ).…”

Section: Introductionmentioning

confidence: 99%

Narrative literature review of antidiabetic drugs’ effect on hyperuricemia: elaborating actual data and mechanisms

Liu,

Kong,

Zhang

2024

J Cosmet Laser Ther

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To optimize the treatment plan for patients with type 2 diabetes mellitus (T2DM) and hyperuricemia, this narrative literature review summarizes the effect of antidiabetic drugs on serum uric acid (SUA) levels using data from observational studies, prospective clinical trials, post-hoc analyses and meta‐analyses. SUA is an independent risk factor for T2DM, and evidence has shown that patients with both gout and T2DM exhibit a mutually interdependent effect on higher incidences. We find that insulin and dipeptidyl peptidase 4 inhibitor (DPP-4i) except linagliptin could increase the SUA, and other drugs including metformin, thiazolidinediones (TZDs), glucagon-like peptide-1 receptor agonists (GLP-1 RAs), linagliptin, sodium-glucose cotransporter 2 inhibitors (SGLT2i) and α-glucosidase inhibitors have a reduction effect on SUA. We explain the mechanisms of different antidiabetic drugs above on SUA and analyze them compared with actual data. For sulfonylureas, meglitinides, and amylin analogs, the underlying mechanism remains unclear. We think the usage of linagliptin and SGLT2i is the most potentially effective treatment of patients with T2DM and hyperuricemia currently. Our review is a comprehensive summary of the effects of antidiabetic drugs on SUA, which includes actual data, the mechanisms of SUA regulation, and the usage rate of drugs.

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Prevalence of Diabetes in Patients with Hyperuricemia and Gout: A Systematic Review and Meta-analysis

Cited by 29 publications

References 57 publications

Fractional Excretion of Urate is Positively Associated with Type 2 Diabetes in HUA Patients: A Cross-Sectional Study

Fractional Excretion of Urate is Positively Associated with Type 2 Diabetes in HUA Patients: A Cross-Sectional Study

The impact of serum uric acid on psoriasis: NHANES 2005–2014 and Mendelian randomization

Narrative literature review of antidiabetic drugs’ effect on hyperuricemia: elaborating actual data and mechanisms

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