Prevalence of Diabetes Mellitus and Diabetic Retinopathy in Persons 50 Years and Above in Katsina State Nigeria: A Population-based Cross-sectional Survey

Rabiu, Muhammad Mansur; Taryam, Manal; Muhammad, Nasiru; Oladigbolu, Kehinde; Abdurahman, Halima

doi:10.1080/09286586.2020.1759105

Cited by 5 publications

(4 citation statements)

References 12 publications

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“…Finally, 73 studies were found eligible through database searches. Four additional studies were identified through citation searches, with a total of n = 77 studies 2,4,5,7–10,12–15,29–94 were included in the meta‐analysis (Figure 1).…”

Section: Resultsmentioning

confidence: 99%

Prevalence of diabetic retinopathy in patients with newly diagnosed type 2 diabetes: A systematic review and meta‐analysis

Cai

Liu

Wang

2022

Diabetes Metabolism Res

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Aims: Type 2 diabetes mellitus (T2DM) can remain undiagnosed for many years, during which micro-and macro-vascular complications may develop. This study aimed to assess the worldwide prevalence of diabetic retinopathy (DR) in patients with newly diagnosed T2DM. Materials and Methods:We systematically searched electronic databases for relevant studies published from inception to 01 January 2022. Selected studies reported the prevalence of DR among patients with newly diagnosed T2DM, specifying the case definition used. Random-effects meta-analysis was used to derive the pooled prevalence. Subgroup and meta-regression analyses were used to investigate variations in the prevalence estimates in terms of available variables.Results: Data from 77 studies including 99,847 patients with newly diagnosed T2DM were included from 26 countries. The pooled prevalence of DR among patients with newly diagnosed T2DM was 13.1% (95% CI, 11.1%-15.1%; I 2 = 97.0%).DR was higher in clinic-based samples compared with community-based samples (15.0%, 95% CI = 12.4%-17.8% vs. 11.5%, 95% CI = 8.9%-14.5%; p = 0.05; I 2 = 97.0%) and was higher in countries in the WHO African 19.2% (95% CI, 14.6%-24.3%; I 2 = 76.0%), South-East Asia 15.4% (95% CI, 10.0%-21.6%; I 2 = 79.1%), and European 15.0% (95% CI, 11.2%-19.2%; I 2 = 82.0%) regions. A higher proportion of female patients was significantly associated with a lower prevalence of DR in patients with newly diagnosed T2DM. We observed that the prevalence of DR in patients with newly diagnosed T2DM has remained unchanged over time.Conclusions: Globally, DR is a prevalent complication among patients with newly diagnosed T2DM indicating the importance of establishing effective strategies to promote regular screening for the early diagnosis of T2DM alongside routine ophthalmic assessment at the time of T2DM diagnosis to reduce the burden of vision-threatening retinopathy.

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Section: Resultsmentioning

confidence: 99%

Prevalence of diabetic retinopathy in patients with newly diagnosed type 2 diabetes: A systematic review and meta‐analysis

Cai

Liu

Wang

2022

Diabetes Metabolism Res

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“…About 14% of adults in America has either diabetes mellitus or impaired fasting glucose levels (17). A study carried out in Katsina state Nigeria, stated that the prevalence of diabetes was 3.3% and 60% of the individuals were unaware of their health status (18).…”

Section: Introductionmentioning

confidence: 99%

Effect of ethyl acetate fraction of Costus afer on glycaemic control and essential haematological and biochemical indices of streptozotocin-induced diabetic rats

Ezeigwe

Onwusulu

Adindu

et al. 2022

J Herbmed Pharmacol

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Introduction: Diabetes mellitus is a common global cause of sudden unpredictable death if undiagnosed and untreated. Costus afer (Costaceae) is a tropical plant with quite a lot of pharmacological properties. This study investigated the prophylactic and antidiabetic properties of ethyl acetate fraction of C. afer in streptozotocin-induced diabetic rats. Methods: Acute toxicity (LD50) test was done using Lorke’s method. Haematological indices were determined using haematology autoanalyser. The biochemical assays were done using standard diagnostic methods. Results: The lethal dose was 3807.9 mg/kg. There was a significant reduction (P < 0.05) in the fasting blood glucose concentration from week one to week four in the group that was pre-treated and later post-treated with 200 mg/kg body weight (bw) of the ethyl acetate fraction of C. afer leaves compared with the untreated diabetic control. The result of the hematological parameters revealed a significant increase (P < 0.05) in the hemoglobin, packed cell volume (PCV), and platelet count of the group pretreated and treated with 200 mg/kg of the fraction compared with the untreated diabetic control. The result of the biochemical assays revealed a far much better recovery from the disruptions caused by the induction of experimental diabetes as seen in the groups that were initially pretreated with 100 and 200 mg/kg before the induction of diabetes compared with the groups treated with the same dose but without pretreatment. Conclusion: C. afer might be used for the prevention and management of diabetes mellitus. Its safety is evidenced by its effects on the hematological and biochemical indices.

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“…Diabetes mellitus (DM) is a group of metabolic disorders associated with hyperglycemia, prevalent worldwide. 1 , 2 DM can lead to several macrovascular complications, such as cardiovascular disease, stroke, chronic kidney disease, foot ulcers, and damage to the nerves and eyes. 2 The ocular complications include keratitis, glaucoma, cataracts, and diabetic retinopathy (DR).…”

Section: Introductionmentioning

confidence: 99%

“… 1 , 2 DM can lead to several macrovascular complications, such as cardiovascular disease, stroke, chronic kidney disease, foot ulcers, and damage to the nerves and eyes. 2 The ocular complications include keratitis, glaucoma, cataracts, and diabetic retinopathy (DR). 3 , 4 In turn, DR is the most common and serious ocular complication, causing progressive damage of the retinal microvasculature.…”

Section: Introductionmentioning

confidence: 99%

Comprehensive Proteomic Profiling of Aqueous Humor Proteins in Proliferative Diabetic Retinopathy

Xiao

Wen

Sun

et al. 2021

Trans. Vis. Sci. Tech.

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Purpose Proliferative diabetic retinopathy (PDR) is a serious ocular disease that can lead to retinal microvascular complications in patients with diabetes mellitus. To date, no studies have explored PDR development by analyzing the aqueous humor (AH). Therefore we carried out tandem mass tag (TMT) proteomic quantification to compare AH protein profiles between PDR and non-PDR subjects. Methods We enrolled six PDR and six control (senile cataract) subjects. AH samples were collected during surgery and stored at –80°C. Proteins were extracted, trypsin-digested, and labeled with TMTs for mass spectrometric analysis. Results We found 191 proteins to be changed with |log 2 (fold change)| ≥1 ( P < 0.05 and identification with at least two peptides per protein). Of them, 111 were downregulated, whereas 80 were upregulated in the PDR group. Proteomic bioinformatic analysis indicated that PDR development was related to complement and coagulation cascades, platelet activation, extracellular matrix–receptor interaction, focal adhesion, protein digestion and absorption, human papillomavirus infection, PI3K-Akt signaling pathway, cholesterol metabolism, peroxisome proliferator-activated receptor signaling pathways, fat digestion and absorption, and vitamin digestion and absorption pathways. Conclusions Comprehensive proteomic profiling of the AH revealed 191 differentially expressed proteins between the two groups. Most of these proteins belong to secretory pathways, and therefore can be used as biomarkers in clinical testing and basic research. Translational Relevance Pathway analysis and a review of the literature enabled us to draw a novel biological map that will support further studies on the underlying mechanisms and therapeutic control of PDR development.

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Prevalence of Diabetes Mellitus and Diabetic Retinopathy in Persons 50 Years and Above in Katsina State Nigeria: A Population-based Cross-sectional Survey

Cited by 5 publications

References 12 publications

Prevalence of diabetic retinopathy in patients with newly diagnosed type 2 diabetes: A systematic review and meta‐analysis

Prevalence of diabetic retinopathy in patients with newly diagnosed type 2 diabetes: A systematic review and meta‐analysis

Effect of ethyl acetate fraction of Costus afer on glycaemic control and essential haematological and biochemical indices of streptozotocin-induced diabetic rats

Comprehensive Proteomic Profiling of Aqueous Humor Proteins in Proliferative Diabetic Retinopathy

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