Prevalence of diabetes mellitus in renal transplant patients with hepatitis B or C virus infection

Hirakauva, Elizabeth Yukie; Ferraz, Maria Lúcia Gomes; Perez, Renata M.; Ferreira, Andressa Coelho; Silva, A.E; Hauache, Omar M.; Pestana, José Osmar Medina

doi:10.1016/s0041-1345(02)03657-6

Cited by 6 publications

(3 citation statements)

References 15 publications

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“…In this study, a significant interaction (P = 0.0001) was found between presence of HCV and use of tacrolimus, since in the HCV-positive group, T2D occurred more often in tacrolimus-treated than cyclosporine A-treated patients (57.8% vs 7.7%; P < 0.0001) [55] . Most subsequent studies confir med this robust association [56][57][58][59][60][61][62][63] , with some exceptions [21,[64][65][66] . Thus, in a recent meta-analysis of 10 studies, the pooled relative risk for post-KT T2D was 2.73 (95% CI: 1.94-3.83) [67] .…”

Section: Association Between Hcv and T2dmentioning

confidence: 94%

“…At a later, cirrhotic stage, however, multiple factors contributing to IR may prevail and partially or completely mask the HCV-related effect. Further evidence has come via case-control studies in which all cases were represented by HCV-infected individuals [16][17][18][19][20][21][22][23][24] , although in most cases, the prevalence of T2D among HCV-infected individuals compared to matched controls was, in general, lower than that seen in previous studies.…”

Section: Association Between Hcv and T2dmentioning

confidence: 99%

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Hepatitis C virus and type 2 diabetes

Negro¹,

Alaei²

2009

WJG

144

118

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This review focuses on the relationship between h e p a t i t i s C v i r u s ( H C V ) i n fe c t i o n a n d g l u c o s e metabolism derangements. Cross-sectional and longitudinal studies have shown that the chronic HCV infection is associated with an increased risk of developing insulin resistance (IR) and type 2 diabetes (T2D). The direct effect of HCV on the insulin signaling has been analyzed in experimental models. Although currently available data should be considered as preliminary, HCV seems to affect glucose metabolism via mechanisms that involve cellular pathways that have been implicated in the host innate immune response. IR and T2D not only accelerate the histological and clinical progression of chronic hepatitis C, but also reduce the early and sustained virological response to interferonalpha-based therapy. Thus, a detailed knowledge of the mechanisms underlying the HCV-associated glucose metabolism derangements is warranted, in order to improve the clinical management of chronic hepatitis C patients.

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Section: Association Between Hcv and T2dmentioning

confidence: 94%

Section: Association Between Hcv and T2dmentioning

confidence: 99%

Hepatitis C virus and type 2 diabetes

Negro¹,

Alaei²

2009

WJG

144

118

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“…In Brazil, anti-HCV prevalence varied from 2 to 7% in DM patients from Central West and South region of Brazil [21–23] while DM2 was observed in 10.3% of renal transplant patients infected with HBV in Brazil [24]. At this moment, little is known about the prevalence of these viruses in other regions of Brazil, the risk factors related to HBV and HCV positivity, HBV and HCV viremia and genotypes in these individuals.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of hepatitis B and hepatitis C among diabetes mellitus type 2 individuals

et al. 2019

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Diabetes mellitus type 2 (DM2) patients have higher risk to be infected with parenterally transmitted viruses, like hepatitis B or C virus. This study aims to determine HBV and HCV infection prevalence in DM2 patients from Northeast and Southeast Brazil. A total of 537 DM2 patients were included, 194 (36.12%) males and 343 (63.87%) females, with mean age of 57.13±11.49 years. HBV and HCV markers were determined using serological and molecular analysis, and risk factors were evaluated in a subgroup from Southeast (n = 84). Two HBV acute (HBsAg+/anti-HBc -) and one HBV chronic case (HBsAg+/anti-HBc+) were found. Six individuals (1.1%) were isolated anti-HBc, 37 (6.9%) had HBV infection resolved (anti-HBc+/anti-HBs+), 40 (7.4%) were considered HBV vaccinated (anti-HBc-/anti-HBs+). Thirteen patients (2.42%) had anti-HCV and 7 of them were HCV RNA+. In the subgroup, anti-HBc positivity was associated to age and anti-HCV positivity was associated to age, time of diabetes diagnosis, total bilirubin, indirect bilirubin, alkaline phosphatase at bivariate analysis, but none of them was statistically significant at multivariate analysis. As conclusion, low prevalence of HBV and high prevalence HCV was found in DM2 patients.

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