Prevalence of Diabetic Retinopathy in Undiagnosed Diabetic Patients: A Nationwide Population-Based Study

Jang, Han Na; Moon, Min Kyong; Koo, Bo Kyung

doi:10.4093/dmj.2021.0099

Cited by 7 publications

(4 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, 7.3% to 18.2% of patients already have DR at the time of diabetes diagnosis, and a previous study reported that among patients with DM, DR might develop 4 to 7 years before the diagnosis of diabetes ( 25 ). Undiagnosed diabetes might have comparable DR risk among those with already known diabetes ( 26 ). Retinopathy lesions may represent early microvascular damage from a combination of insults by various risk factors and individual with different glucose metabolism status susceptibilities to such insults.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of and risk factors for diabetic retinopathy in residents with different types of abnormal glucose metabolism with or without hypertension: A suburban community-based cross-sectional study

Wang

Jiang

et al. 2022

Front. Endocrinol.

View full text Add to dashboard Cite

AimsThe present study examined the prevalence and risk factors for diabetic retinopathy (DR) in residents with abnormal glucose metabolism in a community.Methods6029 subjects were included and underwent standardized interviews and comprehensive examinations. Residents with diabetes were divided into nondiabetic retinopathy (NDR) and DR groups and non-hypertension and hypertension groups. Unconditional multivariate logistic regression models were used to analyze the risk factors for DR in different groups.ResultsThe prevalence of DR in diabetes was 9.9%, and the prevalence of retinopathy, which also has the typical signs of DRs, such as retinal microaneurysms, in prediabetes and normal glucose tolerance was 5.2% and 5.3%, respectively. An elevated waist-to-hip ratio (WHR) (female≥0.85, male≥0.9)[OR 1.683, 95% CI (1.016, 2.790)], systolic blood pressure (SBP)≥140 mmHg [OR 1.875, 95% CI (1.158, 3.034)], elevated HbA1c [OR 1.410, 95% CI (1.220, 1.629)], HbA1c ≥6.5% [OR 2.149, 95% CI (1.320, 3.498)], antidiabetic drug use [OR 3.798, 95% CI (2.209, 6.529)], elevated fasting blood glucose [OR 1.176, 95% CI (1.072, 1.289)], elevated postprandial blood glucose [OR 1.090, 95% CI (1.033, 1.150)] and nonspecific ST-T segment changes on electrocardiography [OR 2.555, 95% CI (1.556, 4.196)] were risk factors for DR. Duration of diabetes [OR 1.206, 95% CI (1.028, 1.415)], elevated WHR [OR 3.796, 95% CI (1.144, 12.603)], elevated waist circumference [OR 6.874, 95% CI (1.403, 33.665)], elevated HbA1c [OR 1.435, 95% CI (1.046, 1.970)], HbA1c ≥6.5% [OR 6.850, 95% CI (1.771, 26.501)], and concurrent metabolic syndrome [OR 3.975, 95% CI (1.144, 13.815)] were risk factors for DR in diabetes without hypertension, and elevated HbA1c [OR 1.395, 95% CI (1.183, 1.645)], HbA1c ≥6.5% [OR 1.745, 95% CI (1.027, 2.966)], use of antidiabetic drugs [OR 4.781, 95% CI (2.624, 8.711)], elevated fasting blood glucose [OR 1.146, 95% CI (1.034, 1.270)], elevated postprandial blood glucose [OR 1.083, 95% CI (1.020, 1.151)], and nonspecific ST-T segment changes on electrocardiography [OR 2.616, 95% CI (1.531, 4.469)] were risk factors for DR in diabetes with hypertension.ConclusionRetinopathy was found in subjects with normal glucose tolerance and prediabetes. There were differences in risk factors for DR in diabetic patients with and without hypertension.

show abstract

Section: Discussionmentioning

confidence: 99%

Prevalence of and risk factors for diabetic retinopathy in residents with different types of abnormal glucose metabolism with or without hypertension: A suburban community-based cross-sectional study

Wang

Jiang

et al. 2022

Front. Endocrinol.

View full text Add to dashboard Cite

show abstract

“…present, DR is mainly detected through early screening. However, due to the limitations of screening, when DR is found, characteristic blood vessel changes have already occurred in the fundus, which endangers vision [24]. Although the effects of RNV can be mitigated by laser photocoagulation or injection of anti-VEGF drugs, because the mechanism of RNV is not yet de nite, there is still no effective method for the treatment of DR [25].…”

Section: Discussionmentioning

confidence: 99%

Exosomal miR-135a-5p promotes neovascularization via targeting SIRT1 in diabetic retinopathy

Tong

et al. 2022

Preprint

View full text Add to dashboard Cite

Background: Diabetic retinopathy (DR) is one of the most serious microvascular complications of diabetes mellitus. Retinal neovascularization （RNV) under the continuous influence of hyperglycemia is the main cause of blindness in DR patients, but the mechanism of neovascularization has not been fully elucidated yet. In this study, we investigated the effect of exosomes secreted by human retinal pigmented epithelial (ARPE-19) cells at high glucose concentrations on in vitro angiogenesis of human umbilical vein endothelial cells(HUVECs). The role of exosomal miRNAs in the pathogenesis of DR was explored.Methods: Exosomes were extracted from the supernatant of ARPE-19 cells by differential centrifugation. Confocal microscopy was used to observe whether exosomes could be taken up by HUVEC, and the effects of exosomes on HUVEC angiogenesis under three sets of glucose concentrations were observed by co-culture and in vitro angiogenesis. The expression of 21 candidate miRNAsin exosomes and 22 candidate mRNAsin HUVEC after the effect of three sets of glucose concentrations was examined by qRT-PCR. Prediction of miRNA-targeted regulatory mRNAs by bioinformatics. Regulation of miR-135a-5p expression by transfection of small interfering RNA and miRNA mimic. Western blot and qRT-PCR were performed to detect the expression of SITR1.Results: Confocal images show that high glucose-induced exosomes （HG-exo） can be taken up by HUVECs and promote the tube formation of HUVECs in vitro. The results of qRT-PCR showed that the expressions of miR-9-3p, miR-135a-5p, miR-134-5p, miR-195-3p, miR-181c-5p and miR-132-3p were upregulated in HG-exo (P < 0.05). The expressions of HIF-1α, SIRT1 and SPRED1 in HUVECs co-cultured with HG-exo were decreased (P < 0.05). Bioinformatics analysis indicated that miR-135a-5p binds to the SIRT1 3'UTR region. We verified this by transfection experiments and showed that miR-135a-5p could inhibit the expression of SIRT1 mRNA and protein.Conclusions:In the presence of high glucose, exosomal miR135a-5p secreted by ARPE-19 cells targeted the SIRT1 3'UTR region and inhibited SIRT1 expression, which in turn promoted neovascularization.

show abstract

“…Because participants in the KNHANES were sampled using a stratified, multistage probability cluster sampling design to represent the whole Korean population [ 22 , 23 ], complex sample analysis was necessary for the present data. Data for men and women were separately analyzed because of sex differences in the formulae for the visceral adiposity indices.…”

Section: Methodsmentioning

confidence: 99%

Novel Asian-Specific Visceral Adiposity Indices Are Associated with Chronic Kidney Disease in Korean Adults

et al. 2023

View full text Add to dashboard Cite

Background:The Chinese visceral adiposity index (CVAI) and new visceral adiposity index (NVAI) are novel indices of visceral adiposity used to predict metabolic and cardiovascular diseases in Asian populations. However, the relationships of CVAI and NVAI with chronic kidney disease (CKD) have not been investigated. We aimed to characterize the relationships of CVAI and NVAI with the prevalence of CKD in Korean adults. Methods: A total of 14,068 participants in the 7th Korea National Health and Nutrition Examination Survey (6,182 men and 7,886 women) were included. Receiver operating characteristic (ROC) analyses were employed to compare the associations between indices of adiposity and CKD, and a logistic regression model was used to characterize the relationships of CVAI and NVAI with CKD prevalence. Results: The areas under the ROC curves for CVAI and NVAI were significantly larger than for the other indices, including the visceral adiposity index and lipid accumulation product, in both men and women (all P<0.001). In addition, high CVAI or NVAI was significantly associated with a high CKD prevalence in both men (odds ratio [OR], 2.14; 95% confidence interval [CI], 1.31 to 3.48 in CVAI and OR, 6.47; 95% CI, 2.91 to 14.38 in NVAI, P<0.05) and women (OR, 4.87; 95% CI, 1.85 to 12.79 in CVAI and OR, 3.03; 95% CI, 1.35 to 6.82 in NVAI, P<0.05); this association remained significant after adjustment for multiple confounding factors in men and women. Conclusion: CVAI and NVAI are positively associated with CKD prevalence in a Korean population. CVAI and NVAI may be useful for the identification of CKD in Asian populations, including in Korea.

show abstract

Prevalence of Diabetic Retinopathy in Undiagnosed Diabetic Patients: A Nationwide Population-Based Study

Cited by 7 publications

References 44 publications

Prevalence of and risk factors for diabetic retinopathy in residents with different types of abnormal glucose metabolism with or without hypertension: A suburban community-based cross-sectional study

Prevalence of and risk factors for diabetic retinopathy in residents with different types of abnormal glucose metabolism with or without hypertension: A suburban community-based cross-sectional study

Exosomal miR-135a-5p promotes neovascularization via targeting SIRT1 in diabetic retinopathy

Novel Asian-Specific Visceral Adiposity Indices Are Associated with Chronic Kidney Disease in Korean Adults

Contact Info

Product

Resources

About