Prevalence of Diagnosed Adult Immune Thrombocytopenia in the United Kingdom

Bennett, Dimitri; Hodgson, M. Elizabeth; Shukla, Amit; Logie, John

doi:10.1007/s12325-011-0084-3

Cited by 37 publications

(34 citation statements)

References 30 publications

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“…However, our estimate of prevalence was higher probably because we included patients over 64 years old and included patients without private insurance. Our annual prevalence estimates are higher than the adult estimates from Bennett, et al (18) possibly due to the differences between cases identified from administrative data compared to electronic medical records or differences between the USA and UK.…”

Section: Discussioncontrasting

confidence: 83%

“…(26) The progressively increasing prevalence among older people and a greater prevalence of men relative to women among people 60 years and older is notable. Segal and Powe(17) and Bennett, et al(18) also described increased prevalence among older adults. The increased prevalence of ITP among older people is consistent with previous reports that the annual incidence of ITP is greatest among the oldest age cohorts;(5;13;27) in one of these reports the increased incidence among older males was also described.…”

Section: Discussionmentioning

confidence: 95%

“…Feudjo-Tepie, et al(14) previously reported the annual prevalence of chronic ITP in privately insured adults ages 18–64 years to be 7.1 for 2002 and 9.5 for 2004 per 100,000 adults. Using data from the United Kingdom General Practice Research Database, Bennett, et al(18) previously reported the annual prevalence for adults 18 years old and older for 2003 to be 4.0 per 100,000 adults and for 2004 to be 4.6 per 100,000 adults. The annual prevalence of Segal and Powe(17) is lower than our estimate of the prevalence for children and adults and the annual prevalence of Feudjo-Tepie, et al(14) is lower than our estimate of the prevalence for adults.…”

Section: Discussionmentioning

confidence: 99%

“…However the prevalence of ITP has only been reported in four studies of four different patient groups. (14;16–18) None of these four studies identified patients with ITP of all ages regardless of their clinical characteristics, insurance status, and their source of health care. Therefore the objective of this study was to determine the prevalence of ITP in the State of Oklahoma regardless of age, clinical characteristics, insurance status, or source of health care.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of primary immune thrombocytopenia in Oklahoma

et al. 2012

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Objective To determine the prevalence of ITP in Oklahoma regardless of age, clinical characteristics, insurance status, and source of health care. Study Design and Setting Patients with ITP were identified by the administrative code ICD-9-CM 287.3 in Oklahoma hematologists’ offices for a 2-year period, 2003–2004. Prevalence was estimated separately for children (<16 years old) and adults because of their distinct clinical characteristics. Oklahoma census data for 2000 was used as the denominator. Results Eighty-seven (94%) of 93 eligible Oklahoma hematologists participated; 620 patients with ITP were identified. The average annual prevalences were: 8.1 (95% CI 6.7, 9.5) per 100,000 children, 12.1 (95% CI 11.1, 13.0) per 100,000 adults, and 11.2 (95% CI 10.4, 12.0) per 100,000 population. Among children and adults less than age 70 years, the prevalence was greater among women. Among adults aged 70 years and older, the prevalence was greater among men. The highest prevalence of ITP was among men age 80 years and older. Conclusion These data document for the first time the prevalence of ITP regardless of age, clinical characteristics, insurance status, and source of health care. The methodology developed for this prevalence analysis may be adaptable for epidemiologic studies of other uncommon disorders which lack specific diagnostic criteria and are treated primarily by medical specialists.

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Section: Discussioncontrasting

confidence: 83%

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prevalence of primary immune thrombocytopenia in Oklahoma

et al. 2012

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“…Armed with their validated definition, the authors then set out to determine the frequency of ITP without restrictions, something that had previously only been done using databases of managed health care plans, limited to age groups or by point-prevalence questionnaires [18][19][20][21]. The authors found that the average annual prevalence of ITP was 8.1 per 100,000 children and 12.1 per 100,000 adults.…”

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confidence: 99%

Immune thrombocytopenia: Getting back to basics

Arnold

2012

American J Hematol

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Pre‐target axon sorting in the avian auditory brainstem

Kashima

Rubel

Seidl

2013

J of Comparative Neurology

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Topographic organization of neurons is a hallmark of brain structure. The establishment of the connections between topographically organized brain regions has attracted much experimental attention and it is widely accepted that molecular cues guide outgrowing axons to their targets in order to construct topographic maps. In a number of systems afferent axons are organized topographically along their trajectory as well and it has been suggested that this pre-target sorting contributes to map formation. Neurons in auditory regions of the brain are arranged according to their best frequency (BF), the sound frequency they respond to optimally. This BF changes predictably with position along the so-called tonotopic axis. In the avian auditory brainstem, the tonotopic organization of the second- and third-order auditory neurons in nucleus magnocellularis (NM) and nucleus laminaris (NL) has been well described. In this study we examine whether the decussating NM axons forming the crossed dorsal cochlear tract (XDCT) and innervating the contralateral NL are arranged in a systematic manner. We electroporated dye into cells in different frequency regions of NM to anterogradely label their axons in the XDCT. The placement of dye in NM was compared to the location of labeled axons in XDCT. Our results show that NM axons in XDCT are organized in a precise tonotopic manner along the rostrocaudal axis, spanning over the entire rostrocaudal extent of both the origin and target nuclei. We propose that in the avian auditory brainstem, this pre-target axon sorting contributes to tonotopic map formation in NL.

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Prevalence of Diagnosed Adult Immune Thrombocytopenia in the United Kingdom

Abstract: Introduction: Data regarding the prevalence of

Cited by 37 publications

References 30 publications

Prevalence of primary immune thrombocytopenia in Oklahoma

Prevalence of primary immune thrombocytopenia in Oklahoma

Immune thrombocytopenia: Getting back to basics

Pre‐target axon sorting in the avian auditory brainstem

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