Prevalence of Diagnosed and Undiagnosed Type 2 Diabetes Mellitus Among US Adolescents: Results From the Continuous NHANES, 1999–2010

Abstract

Although prevalence and incidence of type 2 diabetes mellitus (T2DM) are reportedly increasing among adolescents, national data are lacking, particularly in regard to undiagnosed T2DM. To estimate the prevalence of diagnosed and undiagnosed T2DM among US adolescents, we analyzed a nationally representative cross-section of 11,888 adolescents aged 12-19 years who received a diabetes interview in the Continuous National Health and Nutrition Examination Survey during 1999-2010. Among them, a random subsample of 4,661 adolescents also had fasting blood samples collected. Persons who reported a previous diabetes diagnosis and were either taking no medication or taking an oral hypoglycemic agent (with or without insulin) were classified as having T2DM; persons who reported using insulin alone were classified as having type 1 diabetes. Undiagnosed diabetes was defined as a fasting plasma glucose concentration of ≥126 mg/dL and was assumed to be type 2. In the fasting subsample, 31 diabetes cases (types 1 and 2) were identified, representing a prevalence of 0.84% (weighted 95% confidence interval (CI): 0.51, 1.40) (276,638 cases; 95% CI: 134,255, 419,020). Estimates of the prevalences of type 1 and type 2 diabetes were 0.48% (95% CI: 0.23, 1.02) and 0.36% (95% CI: 0.20, 0.67), respectively, indicating that T2DM accounted for 43% of all cases. Further, undiagnosed T2DM prevalence was 0.12% (95% CI: 0.05, 0.31), representing 34% of T2DM cases (40,611 cases; 95% CI: 2,850, 78,373). T2DM accounts for approximately half of adolescent diabetes in the United States, and one-third of these cases are undiagnosed.

Prevalence of Prediabetes and Undiagnosed Diabetes in Canada (2007–2011) According to Fasting Plasma Glucose and HbA1c Screening Criteria

“…The proportion of undiagnosed diabetes in the U.S. compares to that in Canada, ranging from one-fifth to onethird of total diabetes cases (6,18,32,33). For example, studies using the U.S. National Health Examination Survey have suggested that roughly one-third of the total diabetes prevalence is undiagnosed (30)(31)(32).…”

“…For example, studies using the U.S. National Health Examination Survey have suggested that roughly one-third of the total diabetes prevalence is undiagnosed (30)(31)(32). Cowie et al (13) estimated the prevalence of diagnosed diabetes among U.S. adults in 1999-2002 to be 6.5%, with an additional 2.8% prevalence of undiagnosed diabetes.…”

Pediatric Type 2 Diabetes: Prevention and Treatment Through a Life Course Health Development Framework

“…Comparable prevalence estimates for adolescents (15-19 years) in 2001 and 2009 were respectively 0.54 and 0.68 per 1000 (Dabelea et al 2014). Data from 1999 to 2010 NHANES, representative of US youth 12-19 years, indicated a total prevalence of T2DM of 0.36 per 1000 (Demmer et al 2013). This estimate combines diagnosed and undiagnosed cases of T2DM, with approximately 1/3 of the total being undiagnosed but having a fasting glucose level of ≥126 mg/dL (Demmer et al 2013).…”

“…Data from 1999 to 2010 NHANES, representative of US youth 12-19 years, indicated a total prevalence of T2DM of 0.36 per 1000 (Demmer et al 2013). This estimate combines diagnosed and undiagnosed cases of T2DM, with approximately 1/3 of the total being undiagnosed but having a fasting glucose level of ≥126 mg/dL (Demmer et al 2013). The prevalence of pediatric T2DM is higher for females and among minorities in the USA (Dabelea et al 2014).…”

Markers of Accelerated Conversion of Diabetes Mellitus in Various Cardiovascular Risk Patients

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ОРИГИНАЛЬНЫЕ СТАТЬИ

49В последние годы метаболические нарушения рассматриваются как один из важных факторов риска развития сердечно-сосудистых заболеваний (ССЗ), связанных с атеросклерозом [1]. На фоне оптимального контроля таких важных факторов риска как гиперхолестеринемия и гипертония у лиц с ишемической болезнью сердца (ИБС), тем не менее, отмечается увеличение частоты сахарного диабета (СД) 2 типа [2].

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