Prevalence of drug–drug interaction in atrial fibrillation patients based on a large claims data

Momo, Kenji; Kobayashi, Haruna; Sugiura, Yuuka; Yasu, Takeo; Koinuma, Masayoshi; Kuroda, Seiichiro

doi:10.1371/journal.pone.0225297

Cited by 13 publications

(12 citation statements)

References 17 publications

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“…Interruptions in tube feeding and varying vitamin K content, as well as initiation/discontinuation of antibiotics, steroids, and antiviral medications, can lead to fluctuations in the international normalized ratio. 64 , 65 However, due to the ease of monitoring, warfarin remains a viable option once a patient has recovered and is no longer receiving drugs affecting warfarin metabolism. Direct oral anticoagulants, such as anti-Xa inhibitors or dabigatran, may be considered for long-term anticoagulation but should be used with caution in the acutely ill COVID-19 population due to potential drug-drug interactions, administration limitations, and impaired absorption.…”

Section: Managementmentioning

confidence: 99%

Cardiac Arrhythmias in Critically Ill Patients With COVID-19: A Brief Review

Karamchandani

Quintili

Landis

et al. 2021

Journal of Cardiothoracic and Vascular Anesthesia

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Coronavirus disease 2019, caused by severe acute respiratory syndrome coronavirus 2, is now a global pandemic affecting more than 12 million patients across 188 countries. A significant proportion of these patients require admission to intensive care units for acute hypoxic respiratory failure and are at an increased risk of developing cardiac arrhythmias. The presence of underlying comorbidities, pathophysiologic changes imposed by the disease, and concomitant polypharmacy, increase the likelihood of life-threatening arrhythmias in these patients. Supraventricular, as well as ventricular arrhythmias, are common and are associated with significant morbidity and mortality. It is important to understand the interplay of various causal factors while instituting strategies to mitigate the impact of modifiable risk factors. Furthermore, avoidance and early recognition of drug interactions, along with prompt treatment, might help improve outcomes in this vulnerable patient population.

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Section: Managementmentioning

confidence: 99%

Cardiac Arrhythmias in Critically Ill Patients With COVID-19: A Brief Review

Karamchandani

Quintili

Landis

et al. 2021

Journal of Cardiothoracic and Vascular Anesthesia

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“…Bleeding was identified using the target word "bleeding" or "hemorrhage" in the "Japanese standard disease master" within 12 months after starting anti-coagulants [5]; this code was linked to the ICD-10 code. The standard disease master was developed by "The Committee for Controlled Medical Terminology of Japan Association of Medical Sciences" that was responsible for standardizing disease names, and another committee dedicated for assigning codes to the unique disease names.…”

Section: Identification Of Cases Of Bleeding and Predictive Factors Amentioning

confidence: 99%

“…We previously reported that anti-coagulants are involved in drug-drug interactions that increase the incidence of bleeding events after starting anticoagulants [5]. Briefly, pharmacokinetic and pharmacodynamic drug-drug interactions were associated with bleeding events in 3290 AF patients according to a large claims database with 3-month observation periods.…”

Section: Introductionmentioning

confidence: 99%

Predictive factors associated with bleeding in atrial fibrillation patients treated with anti-coagulant drugs using a large claims database

Momo

Shu-toh

Kaneko³

et al. 2020

PLoS ONE

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Objective To identify risk factors for bleeding in atrial fibrillation (AF) patients treated with anti-coagulants such as warfarin, apixaban, edoxaban, dabigatran, rivaroxaban using a large claims database. Methods A claims database for 8926 AF patients from 2004 to 2016 was obtained from JMDC. Inc. We performed a retrospective cohort study in 2796 Japanese AF patients with 4-month screening and 12-month observation periods. Polypharmacy was defined as prescription of over six drugs. Logistic regression analysis was conducted after stratification based on the presence and absence of cerebrovascular diseases to detect the predictive factors for bleeding. Results Polypharmacy was observed in 815 of 2796 (29.1%) patients. A total of 371 AF patients (13.3%) experienced bleeding in the 12-month observation period. Bleeding risk assessment using multiple logistic regression analysis revealed that the odds ratio for the number of coadministered drugs in the elderly (age for �60, �74) was not significant in those without and with cerebrovascular diseases (1.05 [0.99-1.12], N.S. and 1.10 [0.96-1.27], N.S.). In contrast, in the young (age for <60), the number of co-administered drugs was a significant predictive factor in those without and with cerebrovascular diseases (1.09 [1.03-1.16], p = 0.0054 and 1.20 [1.05-1.36], p = 0.0059). Other observed predictors were"history of bleeding" in young and elderly, but "polypharmacy" and "start from warfarin" were observed in only young. Conclusion We determined the bleeding risk in the clinical setting using a large claims database. Physicians and pharmacists need to monitor patients for the initial bleeding signs, particularly in those with these predictive risk factors.

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“…Therefore, nationwide verification is needed to determine whether Japanese ward pharmacists can contribute to improving the proportion of TDM implementation for anti-MRSA agents. Recently, medical “big data”, including claims databases, have been used for research purposes [ 10 – 12 ]. For example, the large Japanese health insurance claims database, named “JMDC claims database” was constructed by the JMDC Inc., Tokyo [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Association of the ward pharmacy service with active implementation of therapeutic drug monitoring for vancomycin and teicoplanin—an epidemiological surveillance study using Japanese large health insurance claims database

Imai

Momo

Kashiwagi

et al. 2020

J Pharm Health Care Sci

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Background Ward pharmacists are required for the active implementation of therapeutic drug monitoring (TDM). This epidemiological study verified whether Japanese ward pharmacists contribute to improving the TDM implementation proportions of anti-methicillin-resistant Staphylococcus aureus (MRSA) agents using the large health insurance claims database. Methods The patients who received intravenous anti-MRSA agents from April 2012 to March 2017 were enrolled. We defined ward pharmacy service as the “drug management and guidance fee” and/or “inpatient pharmaceutical services premium”. In addition, implementation of TDM was identified by “the specific drug treatment management fee”. We compared the proportions of TDM implementation for vancomycin (VCM), teicoplanin (TEIC), and arbekacin (ABK) in the ward and non-ward pharmacy service groups. To avoid confounding, the propensity score method was employed. Moreover, the clinical variables affecting TDM implementation in each anti-MRSA agent were analyzed by using a multiple logistic regression model. Results The following number of patients were included in the study: VCM (n = 2138), TEIC (n = 596), and ABK (n = 142). After propensity score matching, the proportions of TDM implementation for VCM and TEIC were higher in the ward pharmacy service group than in the non-ward pharmacy service group (VCM: 69.2% vs 60.3%, TEIC: 51.4% vs 34.7%), while no significant difference was observed for ABK (21.2% vs 23.1%). As independent clinical variables affecting TDM implementation for VCM and TEIC, several clinical variables, including ward pharmacy services, were extracted. In contrast, no clinical variables were extracted for ABK. Conclusions We found that the ward pharmacy service is associated with the active implementation of TDM for anti-MRSA agents, such as VCM and TEIC.

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Prevalence of drug–drug interaction in atrial fibrillation patients based on a large claims data

Cited by 13 publications

References 17 publications

Cardiac Arrhythmias in Critically Ill Patients With COVID-19: A Brief Review

Cardiac Arrhythmias in Critically Ill Patients With COVID-19: A Brief Review

Predictive factors associated with bleeding in atrial fibrillation patients treated with anti-coagulant drugs using a large claims database

Association of the ward pharmacy service with active implementation of therapeutic drug monitoring for vancomycin and teicoplanin—an epidemiological surveillance study using Japanese large health insurance claims database

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