Prevalence of Drug-Related Problems and Complementary and Alternative Medicine Use in Malaysia: A Systematic Review and Meta-Analysis of 37,249 Older Adults

Chang, Chee Tao; Ang, Ju Ying; Islam, Asiful; Chan, Huan‐Keat; Cheah, Wee Kooi; Gan, Siew Hua

doi:10.3390/ph14030187

Cited by 23 publications

(34 citation statements)

References 63 publications

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“…4,5 The percentage of patients experiencing DRPs is often near or above 50%. This has been found in many different countries, including Malaysia (50%), 6 the Netherlands (53%), 7 and Ethiopia (70%). 5 DRPs were more common in older patients and especially in people with chronic diseases.…”

Section: Introductionmentioning

confidence: 82%

“…For example, a study by Garin et al 35 found that 12% of patients experienced ADRs, but in our sample, only 5% of patients had ADRs. Basheti et al 36 found that 46.1% of outpatients with chronic diseases had nonadherence, and Chang et al 6 estimated that the pooled prevalence of nonadherence to medication was 60.6%. By contrast, in our study, 17.43% of patients experienced nonadherence.…”

Section: Science and Practicementioning

confidence: 99%

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Effects of home drug delivery on drug-related problems: preliminary evidence for improved patient outcomes during the COVID-19 pandemic in Thailand

Chaomuang¹,

Dede²,

Saokaew³

et al. 2022

Journal of the American Pharmacists Association

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Background Drug-related problems cause severe disabilities, premature deaths, and unnecessary costs. Telepharmacy offer easier access to needed medications, preventing DRPs. Adoption has been slow, and it is unclear what aspects of telepharmacy are most important. The COVID-19 pandemic disrupted health services, forcing the rapid adoption of telepharmacy. In Phayao, Thailand, a program was implemented for home delivery of drugs for chronic disease patients. Objectives This study aimed to explore the prevalence and factors associated with DRPs of chronic disease patients who received home drug delivery services. Methods A cross-sectional study was undertaken in Phayao Province located in North Thailand. Simple random sampling was used to select patients from six public hospitals between July and August 2020. Logistic regression was used to analyze multivariate factors that might be related to DRPs. Results 246 participants reported at least one DRP (49.30%). Most participants were female (58.32%) with elementary education (60.72%). Their mean age was 63.69 (SD=12.97) years. The five most common DRPs were changes of drug packaging or drug brands (18.84%), leftover medications of more than two weeks (18.44%), non-adherence (17.43%), having conditions or diseases requiring additional medications (6.81%), and adverse drug reactions (5.21%). Univariate analysis identified number of chronic conditions, diabetes mellitus, dyslipidemia, chronic kidney disease, education level and drug delivery channel as predictors of DRPs. In multivariate analysis, predictors of DRPs were the number of drugs used per day (adjusted odds ratio [aOR] 1.11 [95%CI 1.03-1.19], p=0.004) and dyslipidemia (aOR 1.83 [95%CI 1.18-2.84], p=0.007. Non-adherence was associated with leftover medicines (aOR 4.22 [95%CI 2.44-7.28], p<0.001) Conclusion The present results indicate that home delivery caused no increase and may have caused a decrease in DRPs and patients were highly satisfied. These promising results suggest that home delivery should be continued and further investigated even as the COVID-19 induced emergency subsides.

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Section: Introductionmentioning

confidence: 82%

Section: Science and Practicementioning

confidence: 99%

Effects of home drug delivery on drug-related problems: preliminary evidence for improved patient outcomes during the COVID-19 pandemic in Thailand

Chaomuang¹,

Dede²,

Saokaew³

et al. 2022

Journal of the American Pharmacists Association

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“…First, the included studies did not encompass all the states of the country, so the estimated prevalence might not fully represent the magnitude of drug-resistant TB in Sudan. Second, substantial heterogeneity was observed in the included studies, although this observation is common in meta-analyses on estimating prevalence [ 62 , 63 , 64 ]. Third, all of the included studies were hospital-based studies and none were community-based studies, making the results more susceptible to potential selection bias.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Drug-Resistant Tuberculosis in Sudan: A Systematic Review and Meta-Analysis

et al. 2021

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Drug-resistant tuberculosis (DR-TB) is still one of the most critical issues impeding worldwide TB control efforts. The aim of this systematic review and meta-analysis was to give an updated picture of the prevalence of DR-TB in Sudan. A comprehensive systematic search was performed on four electronic databases (PubMed, Scopus, Web of Science and Google Scholar) to identify all published studies reporting prevalence data of DR-TB in Sudan. Sixteen eligible studies published during 2002–2020 were included. Using meta-analysis of proportions, the pooled prevalence of TB cases with resistance to any anti-TB drugs was 47.0% (95% CI: 35.5–58.6%). The overall prevalence of mono, multi, poly and extensive drug resistance were estimated to be 16.2% (95% CI: 9.0–23.4%), 22.8% (95% CI: 16.0–29.7%), 6.8% (95% CI: 0.5–13.0%) and 0.7% (95% CI: 0–2.1%), respectively. Considering any first-line anti-TB drugs, the resistance prevalence was highest for isoniazid (32.3%) and streptomycin (31.7%), followed by rifampicin (29.2%). In contrast, resistance against second-line drugs was reported for only two antibiotics, namely, ofloxacin (2.1%) and kanamycin (0.7%). Of note, the resistance profile of the previously treated patients was found to be remarkably high compared with the newly diagnosed TB patients. The relatively high prevalence estimation of anti-TB drug resistance warrants strengthening TB control and treatment strategies in Sudan.

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“…A forest plot was generated to present the summarised results and heterogeneity among the included studies. Heterogeneity among studies was assessed using I 2 statistics, in which I 2 values of greater than 75% inidicated substantial heterogeneity [ 17 ]. The significance of heterogeneity was identified using Cochran’s Q-test.…”

Section: Methodsmentioning

confidence: 99%

Prevalence of intestinal protozoan parasites among school children in africa: A systematic review and meta-analysis

et al. 2022

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Introduction Parasitic infections, especially intestinal protozoan parasites (IPPs) remain a significant public health issue in Africa, where many conditions favour the transmission and children are the primary victims. This systematic review and meta-analysis was carried out with the objective of assessing the prevalence of IPPs among school children in Africa. Methods Relevant studies published between January 2000 and December 2020 were identified by systematic online search on PubMed, Web of Science, Embase and Scopus databases without language restriction. Pooled prevalence was estimated using a random-effects model. Heterogeneity of studies were assessed using Cochrane Q test and I2 test, while publication bias was evaluated using Egger’s test. Results Of the 1,645 articles identified through our searches, 46 cross-sectional studies matched our inclusion criteria, reported data from 29,968 school children of Africa. The pooled prevalence of intestinal protozoan parasites amongst African school children was 25.8% (95% CI: 21.2%-30.3%) with E. histolytica/ dispar (13.3%; 95% CI: 10.9%-15.9%) and Giardia spp. (12%; 95% CI: 9.8%-14.3%) were the most predominant pathogenic parasites amongst the study participants. While E. coli was the most common non-pathogenic protozoa (17.1%; 95% CI: 10.9%-23.2%). Conclusions This study revealed a relatively high prevalence of IPPs in school children, especially in northern and western Africa. Thus, poverty reduction, improvement of sanitation and hygiene and attention to preventive control measures will be the key to reducing protozoan parasite transmission.

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Prevalence of Drug-Related Problems and Complementary and Alternative Medicine Use in Malaysia: A Systematic Review and Meta-Analysis of 37,249 Older Adults

Cited by 23 publications

References 63 publications

Effects of home drug delivery on drug-related problems: preliminary evidence for improved patient outcomes during the COVID-19 pandemic in Thailand

Effects of home drug delivery on drug-related problems: preliminary evidence for improved patient outcomes during the COVID-19 pandemic in Thailand

Prevalence of Drug-Resistant Tuberculosis in Sudan: A Systematic Review and Meta-Analysis

Prevalence of intestinal protozoan parasites among school children in africa: A systematic review and meta-analysis

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