Prevalence of drug resistance among HIV-1 treatment-naive patients in Greece during 2003–2015: Transmitted drug resistance is due to onward transmissions

Paraskevis, Dimitrios; Kostaki, Evangelia Georgia; Magiorkinis, Gkikas; Gargalianos, P.; Xylomenos, G.; Magiorkinis, Emmanouil; Lazanas, Marios; Chini, Maria; Nikolopoulos, Georgios K.; Skoutelis, Athanasios; Papastamopoulos, Vasileios; Antoniadou, Anastasia; Παπαδοπουλοσ, Αντωνιοσ; Psichogiou, Mina; Daikos, Georgios; Oikonomopoulou, M.; Zavitsanou, Assimina; Chrysos, George; Paparizos, Vasileios; Kourkounti, Sofia; Sambatakou, Helen; Sipsas, Nikolaos V.; Lada, Malvina; Panagopoulos, Periklis; Maltezos, Efstratios; Drimis, Stelios; Hatzakis, Angelos

doi:10.1016/j.meegid.2017.07.003

Cited by 29 publications

(33 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, all the study sequences which remained unclassified from the previous procedures were tested for the presence of recombination by using the bootscanning approach as implemented in SimPlot v3.5.1 [ 25 ]. HIV-1 subtyping confirmation by phylogenetic and recombination analysis has focused on the characterization of subtypes A1 and B, which are the most prevalent clades in Greece, as described previously [ 19 , 21 ].…”

Section: Methodsmentioning

confidence: 99%

“…The outbreak among people who inject drugs (PWID) in the Athens metropolitan area that ignited in 2011 was a different situation, where most viruses were classified as CRF14_BG followed by CRF35_AD and subtypes A1 and B [ 15 , 20 ]. The local clusters were of considerable importance for the high prevalence of non-nucleoside reverse transcriptase inhibitors (NNRTI) resistance mutations in Greece, where the majority of the most prevalent resistance mutations (e.g., E138A/G, K103N, Y181C) were due to onward transmissions within molecular transmission clusters (MTCs) [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A Nationwide Study about the Dispersal Patterns of the Predominant HIV-1 Subtypes A1 and B in Greece: Inference of the Molecular Transmission Clusters

Kostaki

Gova

Adamis

et al. 2020

Viruses

Self Cite

View full text Add to dashboard Cite

Our aim was to investigate the dispersal patterns and parameters associated with local molecular transmission clusters (MTCs) of subtypes A1 and B in Greece (predominant HIV-1 subtypes). The analysis focused on 1751 (28.4%) and 2575 (41.8%) sequences of subtype A1 and B, respectively. Identification of MTCs was based on phylogenetic analysis. The analyses identified 38 MTCs including 2–1518 subtype A1 sequences and 168 MTCs in the range of 2–218 subtype B sequences. The proportion of sequences within MTCs was 93.8% (1642/1751) and 77.0% (1982/2575) for subtype A1 and B, respectively. Transmissions within MTCs for subtype A1 were associated with risk group (Men having Sex with Men vs. heterosexuals, OR = 5.34, p < 0.001) and Greek origin (Greek vs. non-Greek origin, OR = 6.05, p < 0.001) and for subtype B, they were associated with Greek origin (Greek vs. non-Greek origin, OR = 1.57, p = 0.019), younger age (OR = 0.96, p < 0.001), and more recent sampling (time period: 2011–2015 vs. 1999–2005, OR = 3.83, p < 0.001). Our findings about the patterns of across and within country dispersal as well as the parameters associated with transmission within MTCs provide a framework for the application of the study of molecular clusters for HIV prevention.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Nationwide Study about the Dispersal Patterns of the Predominant HIV-1 Subtypes A1 and B in Greece: Inference of the Molecular Transmission Clusters

Kostaki

Gova

Adamis

et al. 2020

Viruses

Self Cite

View full text Add to dashboard Cite

show abstract

“…The prevalence of TDR in treatment-naive individuals remains stable in most developed countries and the prevalence of acquired drug resistance is decreasing [22][23][24][25][26][27][28][29] . This implies that further transmission of HIV-1 with TDRMs is occurring in ART-naive individuals [6][7][8] .…”

Section: Drug Class Mutations Resistance Interpretationmentioning

confidence: 99%

Triple Class HIV-1 Drug Resistance in Croatia: the First Report

Planinić¹,

Oroz²,

Lepej³

2019

Rad Hrvatske akademije znanosti i umjetnosti

View full text Add to dashboard Cite

“…[2][3][4] However, the emergence and spread of HIV-1 drug resistance are major challenges to the long-term success of ART and have important clinical significance and public health implication including increasing risks of firstline ART failure and onward transmission of drug-resistance strains in ART-naïve individuals. [5][6][7][8] In particular, transmitted drug resistance (TDR) or pre-treatment drug resistance (PDR) can increase the risk of virological failure (VF), and compromise the long-term effectiveness of recommended first-line ART regimens after initiating ART. 9 HIV-1 strains with transmission links can form genetic transmission clusters, which are especially helpful for tracing the transmission source.…”

Section: Introductionmentioning

confidence: 99%

“…Intervention for individuals within a large cluster by prioritizing ART is an effective strategy to reduce new infections. 10 In recent years, transmission clusters formed by TDR were reported among the ART-naïve individuals in some countries, such as China, 11 Denmark, 12 Germany, 13 Switzerland, 14 Britain, 15 Greece, 5 Italy, 16 Spain, 17 America, 18 and Canada, 19 implying the importance of TDR monitoring. Whether the ART rollout in resourcelimited settings also drives the formation of transmission clusters of TDR deserves investigation.…”

Section: Introductionmentioning

confidence: 99%

<p>HIV-1 Drug Resistance in ART-Naïve Individuals in Myanmar</p>

Chen

Wang

et al. 2020

IDR

View full text Add to dashboard Cite

Background: Estimating the prevalence and characterizing the transmission of HIV-1 drug resistance in treatment-naïve individuals are very important in the prevention and control of HIV/AIDS. As one of the areas most affected by HIV/AIDS, few data are currently available for HIV-1 drug resistance in antiretroviral therapy (ART)-naïve individuals in Myanmar, which borders Yunnan, China. Methods: HIV-1 pol sequences from ART-naïve HIV-1-infected individuals during 2008 and 2014 in Myanmar were retrieved from our previous studies. HIV-1 transmitted drug resistance (TDR) and susceptibility to antiretroviral drugs were predicted using the Stanford HIVdb program. HIV-1 transmission cluster (TC) was determined by Cluster Picker. Results: A total of 169 partial pol sequences from ART-naïve HIV-1 positive Burmese were analyzed. The prevalence of TDR was 20.1%. CRF01_AE and BC recombinants appeared to have a higher prevalence of TDR than other subtypes. The V179D/T was found to be very common in the China-Myanmar border region and was involved in half of the transmission clusters formed by HIV-1 drug-resistance strains in this region. Comparison showed that drugresistance mutation profile in Myanmar was very similar to that in Dehong prefecture of Yunnan. By further phylogenetic analysis with all available sequences from the China-Myanmar border region, four HIV-1 drug-resistance-related TCs were identified. Three of them were formed by Burmese long-distance truck drivers and the Burmese staying in Yunnan, and another was formed by Burmese injection drug users staying in Myanmar and Yunnan. These results suggest a potential transmission link of HIV-1 drug resistance between Myanmar and Yunnan. Conclusion: Given the high prevalence of TDR in Myanmar, and the potential risk of crossborder transmission of HIV-1 drug-resistant strains between Myanmar and Yunnan, China, ongoing monitoring of HIV-1 drug resistance in ART-naïve individuals will provide a guideline for clinical antiretroviral treatment and benefit the prevention and control of HIV/AIDS in this border region.

show abstract

Prevalence of drug resistance among HIV-1 treatment-naive patients in Greece during 2003–2015: Transmitted drug resistance is due to onward transmissions

Cited by 29 publications

References 37 publications

A Nationwide Study about the Dispersal Patterns of the Predominant HIV-1 Subtypes A1 and B in Greece: Inference of the Molecular Transmission Clusters

A Nationwide Study about the Dispersal Patterns of the Predominant HIV-1 Subtypes A1 and B in Greece: Inference of the Molecular Transmission Clusters

Triple Class HIV-1 Drug Resistance in Croatia: the First Report

<p>HIV-1 Drug Resistance in ART-Naïve Individuals in Myanmar</p>

Contact Info

Product

Resources

About