Prevalence of dyslipidemia and dysglycaemia in HIV infected patients

Manuthu, Emma M; Joshi,; Gn, Lule; Karari, Emma M

doi:10.4314/eamj.v85i1.9600

Cited by 54 publications

(65 citation statements)

References 0 publications

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“…The prevalence of LDL-c ≥ 150mg/dl in our HAART group was 48.3%. It is comparable with the prevalence reported from Cameron which was 46.4% [24]. The prevalence of raised TG on HAART group was 59.6%, which is comparable with the report from Hawasa-Ethiopia (55.8%) [29].…”

Section: Discussionsupporting

confidence: 87%

“…The prevalence of raised TG on HAART group was 59.6%, which is comparable with the report from Hawasa-Ethiopia (55.8%) [29]. But our finding was higher than studies done in; India, Cameron, Jimma-Ethiopia [24,30,31] reported 32%, 39%, 18.2%, respectively. However, there are suggestions that the magnitude of lipid profile derangements induced by HAART showed variation with duration of treatment, across populations and setting.…”

Section: Discussionsupporting

confidence: 83%

“…The proportion of patients with TC ≥ 200mg/dl among participants on HAART (50%) was higher than the findings reported from; Cameron (37.7%), Hawassa-Ethiopia (43.4%) & Jimma-Ethiopia (6.4%) [24,29,30]. This variation might be due to difference in sampling technique, the cut of value used.…”

Section: Discussionmentioning

confidence: 62%

“…The sample size was determined using two population proportion formula by considering the following assumptions: proportion of HIV positive persons on HAART with LDL-c ≥130 (40.8%) [24] and proportion of HIV positive persons naive for HAART with LDL-c ≥130 (21%) [25]. Level of significance (α/2) = 5%; power (1-β) = 90%; r = (Ratio of exposed: non exposed) = 1:1.…”

Section: Sample Size and Study Subjectsmentioning

confidence: 99%

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Prevalence and Predictors of Dyslipidemia on HAART and HAART Naive HIV Positive Persons in Defense Hospital, Addis Ababa, Ethiopia

Bayenes¹,

Ahmed²,

Shenkute³

et al. 2014

AJHR

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Abstract:Background: The introduction of highly active antiretroviral therapy (HAART) has led to a marked reduction in Acquired Immune Deficiency Syndrome (AIDS) related morbidity and mortality. However, HAART has been reported to be associated with a number of side effects in human immunodeficiency virus (HIV) positive persons among which dyslipidemia and lipodystrophy are common metabolic disorders. Objective: To assess the prevalence and predictors of dyslipidemia among HAART and HAART naive HIV positive persons in Defense Hospital, Addis Ababa-Ethiopia. Methods: A facility based comparative cross-sectional study among 228 HIV positive persons was conducted from September to October 2013. Socio-demographic and clinical data were collected using structured questionnaires. Fasting venous blood sample was drawn for laboratory analysis. Lipid profiles were measured using clinical chemistry analyzer (HumStar80, USA). CD4 cell counting was done using BD FACS Count™ (BD, USA). Anthropometric measurement was done. Data was analyzed using SPSS version 20 for windows. Result: A total of 228, 114 on HAART and 114 HAART naïve HIV positive persons, were enrolled in the study. The overall prevalence of dyslipidemia was 63.6%. Prevalence of dyslipidemia in HAART naive and on HAART HIV positive persons was 61(53.5%) and 84(73.7%), respectively. The prevalence of TC≥200 mg/dl was 50% and 30%; HLD-c<40 mg/dl was 43.8% and 36%; LDL-c≥130mg/dl was 48.3% and 28.1%; and TG≥150 mg/dl 59.6% and 39% among on HAART and HAART naïve, respectively. Age greater than 40 years old (AOR = 3.27, 95% C.I: 1.47 -7.25), blood pressure ≥ 140/90 (AOR = 16.13, 95% C.I: 5.81 -44.75), being on HAART (AOR = 2.73, 95 % C.I: 1.35 -5.53), and body mass index > 25kg/m 2 (AOR = 1.92, 95 % C.I: 1.20 -4.81) were identified as determinants of dyslipidemia. Conclusion: The mean value of lipid profile was significantly higher on HAART as compared to HAART naïve HIV positive persons. It is important to have well controlled cohort studies for the evaluation of long-term effects of HAART on lipid profiles.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 62%

Section: Sample Size and Study Subjectsmentioning

confidence: 99%

See 2 more Smart Citations

Prevalence and Predictors of Dyslipidemia on HAART and HAART Naive HIV Positive Persons in Defense Hospital, Addis Ababa, Ethiopia

Bayenes¹,

Ahmed²,

Shenkute³

et al. 2014

AJHR

View full text Add to dashboard Cite

show abstract

“…A cross-sectional study at KNH between January and April 2006 reported a high prevalence of dyslipidemia of 63.1% (19). This study differs from the current study in that it involved doing lipid profiles for all patients unlike in the current study which recorded clinically apparent lipid abnormalities only.…”

Section: Discussionmentioning

confidence: 62%