Prevalence of dyslipidemia and its association with cardiometabolic factors and kidney function in the adult Romanian population: The PREDATORR study

Popa, Simona; Moța, Maria; Popa, A. R.; Moţa, E; Timar, Romulus; Serafinceanu, Cristian; Cheţa, D; Graur, Mariana; Hâncu, Nicolae

doi:10.1016/j.dsx.2018.11.033

Cited by 12 publications

(11 citation statements)

References 13 publications

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“…Circulating chitotriosidase shows similar values in CRC patients than controls ( Table 2 , Figure 2 ). Opposite to our results, Song et al [ 42 ] reported higher chitinase values in patients with CRC than in controls in the Chinese population. The characteristics of the evaluated population could explain the differences.…”

Section: Discussioncontrasting

confidence: 92%

“…The characteristics of the evaluated population could explain the differences. In Romania, at least one lipid abnormality is reported as 67.1%, and the prevalence of low HDL-cholesterol is 47.8% (95%CI = [46.3 to 49.2%]) [ 42 ]. High neopterin circulating levels have been reported as associated with low HDL-cholesterol levels (high-density lipoprotein) [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

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Exploratory Evaluation of Neopterin and Chitotriosidase as Potential Circulating Biomarkers for Colorectal Cancer

Ciocan

Hajjar

et al. 2023

Biomedicines

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Chronic inflammation is demonstrated to play a direct role in carcinogenesis. Our exploratory study aimed to assess the potential added value of two inflammation biomarkers, chitotriosidase and neopterin, in follow-up evaluation of patients with colorectal cancer (CRC). An observational exploratory study was conducted. Patients with CRC and matched controls (1:1, age, sex, and living environment) were evaluated. The patients with CRC (CRC group) and controls were assessed at baseline (before surgical intervention for patients with CRC). Patients with CRC were also evaluated at 1-year follow-up. Significantly more patients with blood group A (54.5% vs. 25.0%) and smokers (50.0% vs. 22.7%) were in the CRC group. The serum values of chitotriosidase and neopterin were higher in CRC patients than in controls, but only neopterin reached the conventional level of statistical significance (p-value = 0.015). The circulating chitotriosidase and neopterin values decreased significantly at 1-year follow-up (p-value < 0.0001). Patients with higher N- and M-stage showed statistically significant higher levels of chitotriosidase and neopterin at baseline and 1-year follow-up (p-values < 0.03). Circulating chitotriosidase levels also showed statistically significant differences regarding baseline and 1-year follow-up on patients with CRC and different differentiation grades (p-values < 0.02). The circulating levels of neopterin significantly decreased at 1-year follow-up, indicating its potential as a prognostic marker. The circulating values of chitotriosidase and neopterin exhibit significant differences in patients with than without recurrences. Our results support further evaluation of chitotriosidase and neopterin as prognostic markers in patients with CRC.

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Section: Discussioncontrasting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Exploratory Evaluation of Neopterin and Chitotriosidase as Potential Circulating Biomarkers for Colorectal Cancer

Ciocan

Hajjar

et al. 2023

Biomedicines

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“…As both of dietary intake and kidney function could be influenced by sex,16 age,3 body mass index (BMI),3 socioeconomic position (education, occupation and family income),17 18 personal lifestyles (smoking status, alcohol use and physical activity),19–21 daily energy intake,22 self-rated health and chronic disease history (hypertension, dyslipidaemia and diabetes),3 23 these factors were considered as potential confounders and included in our analysis.…”

Section: Methodsmentioning

confidence: 99%

Associations of meat, fish and seafood consumption with kidney function in middle-aged to older Chinese: a cross-sectional study based on the Guangzhou Biobank Cohort Study

Lu,

Zhang,

Zhu

et al. 2023

BMJ Open

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ObjectiveTo examine the associations of red meat, poultry, fish and seafood and processed meat consumption with kidney function in middle-aged to older Chinese.DesignA cross-sectional study based on the Guangzhou Biobank Cohort Study.SettingCommunity-based sample.Participants9768 participants (2743 men and 7025 women) aged 50+ years.Primary and secondary outcome measuresPrimary outcome was estimated glomerular filtration rate (eGFR) derived from the Chinese-specific equation based on the Modification of Diet in Renal Disease (MDRD) equation (c-aGFR). eGFR derived from the original isotope-dilution mass spectrometry-traceable MDRD study equation, and prevalent chronic kidney disease (CKD) defined as c-aGFR<60 mL/min/1.73 m2were considered the secondary outcomes.ResultsAfter adjusting for sex, age, body mass index, education, occupation, family income, smoking status, alcohol use, physical activity, daily energy intake, self-rated health and chronic disease history (diabetes, hypertension and dyslipidaemia), compared with processed meat consumption of 0–1 portion/week, those who consumed ≥3 portions/week had lower c-aGFR (β=−2.74 mL/min/1.73 m2, 95% CI=−4.28 to −1.20) and higher risk of prevalent CKD (OR=1.40, 95% CI=1.09 to 1.80, p<0.0125). Regarding fish and seafood consumption, the associations varied by diabetes (p for interaction=0.02). Fish and seafood consumption of ≥11 portions/week, versus 0–3 portions/week, was non-significantly associated with higher c-aGFR (β=3.62 mL/min/1.73 m2, 95% CI=−0.06 to 7.30) in participants with diabetes, but was associated with lower c-aGFR in normoglycaemic participants (β=−1.51 mL/min/1.73 m2, 95% CI=−2.81 to −0.20). No significant associations of red meat or poultry consumption with c-aGFR nor prevalent CKD were found. Similar results were found for meat, fish and seafood consumption with eGFR.ConclusionsHigher processed meat, fish and seafood consumption was associated with lower kidney function in normoglycaemic participants. However, the associations in participants with diabetes warrant further investigation.

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“…In an epidemiological study including a large Romanian population, there were higher levels of IR in metabolically unhealthy lean, and metabolically healthy obese patients vs. controls (7). In addition, longitudinal studies have indicated an association between thyroid function and IR (8,9).…”

Section: Introductionmentioning

confidence: 98%

Subclinical hypothyroidism has no association with insulin resistance indices in adult females: A case‑control study

et al. 2021

Self Cite

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Longitudinal studies have indicated an association between thyroid function and insulin resistance (IR) or a neutral relationship. Both the lowest tertile of free thyroxine (fT4) and the highest tertile of free triiodothyronine (fT3) were found to be associated with IR in cross-sectional studies. The aim of the present study was to analyze the association between IR and subclinical hypothyroidism in a female adult population from Bucharest, Romania. This is a retrospective pilot case-control study that included female patients examined by two endocrinologists and a diabetologist in an outpatient clinic. The retrospective follow-up had a one-year duration and included the evaluation of thyroid function tests and IR indices based on fasting insulinemia and C-peptide. The study included 176 women, 91 with subclinical hypothyroidism, with a median age of 60±17 years and a mean body mass index (BMI) of 27.79±4.76 kg/m 2 . The majority of the population (50%) was diagnosed with autoimmune thyroiditis, and 17.05% with goitre. The univariate logistic regression using hypothyroidism as the explaining variable found no evidence of a significant relationship between a decreased thyroid function and IR (OR 1.32; P=0.36). Metabolic syndrome was probably the most important determinant of IR in the population group studied. Thus, it was not the thyroid function per se, but the coexistence of other elements of this syndrome that prevailed in determining IR. Advantages to the study are the design that permitted evaluation of IR and the thyroid function at different moments in time as well as the uniformity of the blood tests. The multivariate analyses were adjusted for age, lipid profile and treatment; however, one limiting factor was the absence of other hormonal blood tests. In summary, there was no association between the thyroid function tests (TSH, fT4) and IR indices in adult Romanian women in a case-control study with one-year retrospective follow-up.

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Prevalence of dyslipidemia and its association with cardiometabolic factors and kidney function in the adult Romanian population: The PREDATORR study

Cited by 12 publications

References 13 publications

Exploratory Evaluation of Neopterin and Chitotriosidase as Potential Circulating Biomarkers for Colorectal Cancer

Exploratory Evaluation of Neopterin and Chitotriosidase as Potential Circulating Biomarkers for Colorectal Cancer

Associations of meat, fish and seafood consumption with kidney function in middle-aged to older Chinese: a cross-sectional study based on the Guangzhou Biobank Cohort Study

Subclinical hypothyroidism has no association with insulin resistance indices in adult females: A case‑control study

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