Prevalence of Dyslipidemia in Patients with Malignant Hypertension

Abstract

Background: This study was designed to examining the prevalence of dyslipidaemia in patients with malignant hypertension. Methods: We have attempted to compare patients presenting with MHT to normotensive controls and patients with untreated essential hypertension. Results: Anticipated differences in blood pressure, serum creatinine concentration was greater in the MHT group than in either of the other two groups. Total LDL-cholesterol concentrations similar in all three groups (table 2). The most notable finding, however, was of markedly lower HDL-cholesterol concentrations in the MHT group (p<0.01). The total: HDL-cholesterol ratio was therefore significantly higher in the MHT group than either of the other two groups. Serum triglycerides were greater in the MHT group than in the NC group (p=0.03). These analyses show that whilst the differences in HDL-cholesterol concentration between the MHT group and the other two groups remained, there were no differences in serum triglycerides or measures. Results for total and LDLcholesterol concentration remained unchanged. Conclusion: MHT may be associated with an abnormal lipid profile especially total cholesterol, triglycerides and LDL-cholesterol concentration characterized by low-HDL-cholesterol concentrations. Higher levels of these lipids may be contributed due to physical inactivity, stress, increased age, alcohol consumption and high consumption of dietary fat etc.

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“…Diabetes mellitus diagnosed by blood glucose ≥200 mg/dL or HbA1C ≥6.5% or being a known diabetic and receiving medications ( 8 ). Dyslipidemia was diagnosed as serum cholesterol of ≥200 mg/dL, triglyceride >150 mg/dL, low-density lipoprotein (LDL) >100 mg/dL, <70 mg/dL for patients with diabetes or heart disease ( 9 ). Family history of premature ischemic heart disease defined as male <55 years or female <65 years in first-degree family members.…”