Prevalence of early-onset androgenetic alopecia and its relationship with lifestyle and dietary habits

Ağaoğlu, Esra; Erdoğan, Hilal Kaya; Acer, Ersoy; Atay, Emrah; Metintaş, Selma; Saraçoğlu, Zeynep Nurhan

doi:10.23736/s2784-8671.21.06874-7

Cited by 5 publications

(6 citation statements)

References 24 publications

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“…Previous study by Esra, et al on early-onset AGA found that people with moderate to severe AGA had a greater body mass index, which concludes that dietary habits and lifestyle have roles in early-onset AGA. 10 In our study, we found that the subjects' BMI across all groups were obese and had mean waist circumference > 90 cm. No statistically signi cant differences were found between groups.…”

Section: Sociodemographic and Clinical Characteristicsmentioning

confidence: 53%

Hair Regeneration in Androgenetic Alopecia using Secretome of Adipose-derived Stem Cells (ADSC) and Minoxidil: A Comparative Study of Three Groups

Legiawati,

Sitohang,

Yusharyahya

et al. 2024

Preprint

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Introduction: Androgenetic alopecia (AGA) is one of the most common cause of hair loss disorder, characterized by the shortening duration of anagen phase, increased telogen phase, and miniaturization of hair follicles, eventually leading to their regression. This disorder tends to progress into partial or even complete baldness. Several therapeutic options are now available for AGA, including conventional medications such as finasteride, dutasteride, and minoxidil. However, side effects of these medications are also commonly reported. The use of adipose derived stem cells (ADSCs) and their secreted bioactive molecules, “secretome” has gained attention which could produce many effects for hair growth promotion and has been proven in clinical trials. However, there is still insufficient evidence regarding the comparison of effectiveness of secretome with treatments like minoxidil. Objective: This study aims to compare the effectiveness and safety of secretome from ADSCs with minoxidil in AGA cases, to provide future reference in the application of cell-based therapy in AGA cases. Method: 60 subjects were divided into three treatment groups (minoxidil only, secretome only, and combination of both) and were given intervention on week 0, 4, and 8. All subjects were evaluated by physical examination, photography, trichoscopy, and trichoscan until week 12. Results: All groups showed a statistically significant improvement (p <0.05) on hair growth parameters from week 4, with the best improvement observed on week 12. There were a significant difference between groups on some of the delta hair growth parameters (p <0.05), observed between secretome and combination groups. The combination group had the best improvement substantially on hair growth parameters. Side effects are minimum and only reported by the subjects in minoxidil group. Conclusion: All of the interventions give a significant improvement on hair growth with the best improvement observed after 12 weeks. However, the best improvement substantially were observed in combination group.

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Section: Sociodemographic and Clinical Characteristicsmentioning

confidence: 53%

Hair Regeneration in Androgenetic Alopecia using Secretome of Adipose-derived Stem Cells (ADSC) and Minoxidil: A Comparative Study of Three Groups

Legiawati,

Sitohang,

Yusharyahya

et al. 2024

Preprint

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“…Several risk factors were found to be significantly associated with early-onset AGA. These included family history [ 10 , 12 , 23 ], lifestyle factors such as cigarette smoking [ 10 , 21 ] and unhealthy dietary habits [ 10 ]. Additionally, severe AGA was more prevalent in men aged between 30 and 40 years with higher body mass index (BMI) [ 22 ].…”

Section: Resultsmentioning

confidence: 99%

“…Early-onset AGA is generally defined as AGA developing before the age of 30 [ 4 , 5 ], 35 [ 6 , 7 ] or 40 [ 8 , 9 ] years; however, there is currently no unified definition. Although the frequency of AGA increases with age, the prevalence of early-onset cases is substantial, ranging from 19.2%-57.6% in different populations [ 10 – 12 ]. In addition to harmfully affecting the patient’s appearance and quality of life [ 13 , 14 ], AGA is closely associated with the risk of developing metabolic syndrome (MetS) [ 15 , 16 ], which is a cluster of metabolic abnormalities including obesity, hyperlipidemia, insulin resistance (IR), and hypertension.…”

Section: Introductionmentioning

confidence: 99%

Factors associated with early-onset androgenetic alopecia: A scoping review

Liu,

Wariboko,

et al. 2024

PLoS ONE

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Background Early-onset androgenetic alopecia (AGA) has been associated with various chronic conditions, including metabolic syndrome (MetS). Gaining a deep understanding of early-onset AGA may enable earlier intervention in individuals at high risks. This scoping review aims to explore the risk factors and etiology, associated conditions, and adverse effects on wellbeing in early-onset AGA. Methods Electronic literature searches were conducted in MEDLINE, EMBASE and CENTRIAL. Eligible studies included case-control, cohort, cross-sectional, and meta-analysis studies. Selected studies needed to clearly define early-onset AGA cases or include only cases starting before the age of 40 and compare them with appropriate controls. The exclusion criteria comprised editorials, commentaries, case series, and non-systematic reviews, among others. Data extraction involved collecting study characteristics, methodologies, main outcomes, and findings. Descriptive tables were used to summarize key information and relevant variables when necessary. Results Among the 65 eligible articles, 67.69% were case-control studies and 78.46% evaluated only male patients. “Early-onset” was defined as cases developing before the age of 30 years in 43.08% of the studies. The Hamilton–Norwood scale was the most frequently used method for evaluating the severity of alopecia in men (69.23%). Reported risk factors for early-onset AGA included a family history of AGA, cigarette smoking, unhealthy dietary habits, and a high body mass index. Early-onset AGA may also be associated with hormonal profiles, 5α-reductase enzyme activity, androgen receptor genes, and some susceptibility loci. Comorbidities investigated included MetS, cardiovascular disease, insulin resistance, dyslipidemia, and Parkinson’s disease. Men with early-onset AGA may have reduced treatment efficacy with drug like rosuvastatin, metformin or lisinopril for dyslipidemia, prediabetes, or hypertension. Additionally, young men with AGA tended to suffer from psychological issues such as anxiety and low self-esteem compared to those without hair loss. Conclusion Early-onset AGA is a complex condition with various risk factors and etiology, associated comorbidities, and potential implications for treatment response and psychological health.

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“…People's dietary habits also affect AGA. Yanhua Yi et al found that alcohol intake increased the severity of female pattern baldness [ 95 ]. Agaoglu et al believe that red meat consumption and insufficient intake of fruits and vegetables are risk factors for early onset AGA in young men [ 96 ].…”

Section: Human Behaviorsmentioning

confidence: 99%

Comorbidities in Androgenetic Alopecia: A Comprehensive Review

Chen

Xie

Zhang

et al. 2022

Dermatol Ther (Heidelb)

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Androgenetic alopecia is the most common form of hair loss, affecting 85% of men and 40% of women. Androgenetic alopecia is a disease caused by multiple factors, such as genetics, hormones, and systemic diseases; however, the exact cause remains undetermined. Recent studies have found that it is associated with a high incidence of endocrine diseases and other comorbidities. It may not only be a skin disease but also an early signal of underlying systemic diseases. Effective management requires timely diagnosis and treatment initiation. However, in current clinical practice, androgenetic alopecia is still not fully understood or treated. Recognizing the true physical, social, and emotional burden of androgenic alopecia, as well as its associated comorbidities, is the first step in improving the prognosis of affected patients. This review aimed to gather the known pathological factors and provide a reference for clinical physicians to understand androgenetic alopecia and its comorbidities in depth, thereby enabling early recognition of the underlying systemic diseases and providing timely treatment.

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Prevalence of early-onset androgenetic alopecia and its relationship with lifestyle and dietary habits

Cited by 5 publications

References 24 publications

Hair Regeneration in Androgenetic Alopecia using Secretome of Adipose-derived Stem Cells (ADSC) and Minoxidil: A Comparative Study of Three Groups

Hair Regeneration in Androgenetic Alopecia using Secretome of Adipose-derived Stem Cells (ADSC) and Minoxidil: A Comparative Study of Three Groups

Factors associated with early-onset androgenetic alopecia: A scoping review

Comorbidities in Androgenetic Alopecia: A Comprehensive Review

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