Prevalence of electrocardiographic left ventricular hypertrophy in malignant hypertension and its correlation with renal function

Islim, I. F.; Beevers, M.; Muthuswamy, S.; Bannergy, A.; Singh, Sushma; Beevers, D. G.

doi:10.1097/00004872-199312050-00032

Cited by 2 publications

(1 citation statement)

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“…Our findings are consistent with previous work of other investigators which also confirms a high prevalence of LVH among MHT patients. [16][17][18] Indeed, the identification of LVH in patients with MHT is of great importance, in view of the relationship between LVH and arrhythmias, as well as sudden death. 19,20 These arrhythmias could in part explain the increased mortality seen in untreated MHT patients, 3 or in subjects where the treatment may be suboptimal.…”

Section: Discussionmentioning

confidence: 99%

Echocardiographic changes in patients with malignant phase hypertension: The West Birmingham Malignant Hypertension Register

2004

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In order to study the echocardiographic abnormalities in consecutive patients with malignant phase hypertension (MHT), we reviewed echocardiograms of 31 patients (23 male; mean age 52714 years) with MHT who were admitted to our unit. Trans-thoracic echocardiography was carried out in all patients, and echocardiographic measurements were compared with those of 39 patients (30 male; mean age 54710 years) with controlled nonmalignant essential hypertension, and 32 (19 male; mean age 51710 years) healthy normotensive volunteers. Patients with MHT had a significantly higher mean systolic and diastolic blood pressure (Po0.001) compared to the other two groups. MHT patients had significantly greater mean left atrial dimensions (P ¼ 0.002), as well as aortic root dimensions (P ¼ 0.01) and left ventricular (LV) dimensions (with the exception of the diastolic internal diameter) (Po0.001). MHT patients also had a mean larger LV mass and LV mass index (both Po0.001) when compared to the other two groups. The mean ejection fraction was also lower in the MHT group (Po0.001). In conclusion, patients with MHT have significant cardiac hypertrophy, in association with systolic dysfunction and dilated left atria, irrespective of the duration of known hypertension. These abnormalities may predispose MHT patients to cardiovascular complications including heart failure and cardiac arrhythmias, such as atrial fibrillation.

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