Prevalence of Elevated Glycated Hemoglobin Concentrations in the Polycystic Ovary Syndrome: Anthropometrical and Metabolic Relationship in Amazonian Women

Abstract

BackgroundTo determine the prevalence of elevated glycated hemoglobin (HbA1c) and to examine its relationship with other carbohydrate metabolic parameter among Brazilian women with polycystic ovary syndrome (PCOS).MethodsA cross-sectional study including 288 PCOS patients was conducted. Anthropometrical, clinical, biochemical and endocrine parameters were evaluated.ResultsThe mean age was 26.92 ± 5.51 years. HbA1c mean concentration was 5.83±1.34%. In 38.54% of patients, HbA1c was ≥ 5.7%. HbA1c was positively correlated with body weight (r = 0.142, P = 0.017), body mass index (P = 0.000), waist:hip ratio (P = 0.000), fat mass (P = 0.000), conicity index (P = 0.000), triglyceride (P = 0.001), C-peptide (P = 0.000), total testosterone (P = 0.003), free testosterone (P = 0.000), free androgen index (P = 0.006) and fasting insulin (P = 0.025). Using the oral glucose tolerance test, HbA1c showed positive correlation with glucose concentrations at any point in time (P < 0.05).ConclusionsHbA1c was elevated in nearly 40% of PCOS patients and it showed positive correlation with several anthropometric and metabolic factors and androgen levels. The current study provides further evidence that HbA1C is higher in PCOS patients and may have a potential role in the prediction of dysglycemic disease in these women.

Changes in clinical and biochemical characteristics of polycystic ovary syndrome with advancing age

“…Primary hypothyroidism was excluded by a thyroid-stimulating hormone (TSH) level of ≤4.2 µUI/mL and free thyroxin (fT4) level of ≤9.0 pmol/L (28,29). Hyperprolactinemia was excluded when prolactin (PRL) levels were ≤1.1 nmol/L (30). Before analysis PCOS patients were also stratified in categories according to age, as follows: younger than 19 years, 20 to 24 years, 25 to 29 years, 30 to 34 years, 35 to 39 years.…”

“…Blood samples were taken by cubital venipuncture between 7:30 and 10:00 h, after 10-12 h of fasting, between the third and fifth days of a spontaneous menstruation or, in the case of infrequent menses or amenorrhea, on any day regardless of the time elapsed since the last menstrual period; in this case, the progesterone (P4) level was used to certify that samples were collected in the follicular phase and the results were validated whenever the P4 level was lower than 6.3 nmol/L (30). A glucose oxidase technique (Beckman Glucose Analyses, Fullerton, CA, USA) was used to measure fasting glucose.…”

Assessment of glycated hemoglobin and uric acid level in polycystic ovarian syndrome in a Tertiary Care Institute of Marathwada region

“…In a study by Sebastiao Medeiros et al; HbA1c was raised in 38% PCOS patients; 35% with prediabetes and 3% with diabetes. 7 Jin Ju Kim et al found 31.2% prevalence of raised HbA1c in PCOS women. 13 de Medeiros SF et al, found that HbA1c was raised in 46 % of PCOS women.…”

“…Taking into account this potential association between HbA1c and health consequences in PCOS patients, the current study aimed to estimate the prevalence of elevated HbA1c in PCOS women in our institute. 7 PCOS is characterized by increased activation of the inflammatory system stemming from insulin resistance, which predicts future cardiovascular risk. 8 IR elevates several proinflammatory mediators, which leads to endothelial dysfunction, reduced vasoreactivity, and subclinical atherosclerosis.…”

Metabolic and endocrine connections of 17-hydroxypregnenolone in polycystic ovary syndrome women

“…After standardization of the diagnostic criteria for polycystic ovary syndrome (PCOS) the hyperandrogenemic phenotype has been found in nearly 80% of patients ( 1 , 2 ). These hyperandrogenemic patients may have their androgen synthetized by ovaries, adrenal gland, or both.…”