Prevalence of Elevated Non-HDL Cholesterol among Patients with Diabetes in An Iranian Population

Abstract


 
 
 Background and Aims: Non-high density lipoprotein cholesterol (non-
 HDL-C), which reflects all cholesterol present in potentially atherogenic lipoprotein particles, might be a useful marker of atherosclerosis in diabetic subjects. In the present study, we evaluated the prevalence of high non-HDL-C in patients with dyslipidemia in diabetic and non-diabetic subjects following LDL-C assessment as the first goal of therapy. Materials and Methods: A data set of 2142 individuals was included in the study. All values of lipid profile were compared between non-diabetic and diabetic groups and the prevalence of dyslipidemia was evaluated in two groups.
 Results and Conclusions: According to the results, 48% of patients with diabetes achieved combined LDL-C ≤2.5 mmol/L and non-HDL ≤3.3 mmol/L targets, and 58.2% of diabetic patients achieved LDL-C goal while only 50.2% attained non-HDL-C goal. Also, the results indicated that non-HDL-C significantly heightened in patients with diabetes. Therefore, non-HDL-C needs to be calculated as a routine assessment in patients with diabetes.
 
 

The pattern of dyslipidaemia and factors associated with elevated levels of non-HDL-cholesterol among patients with type 2 diabetes mellitus in the Ho municipality: A cross sectional study

“…Non-HDL-C defines all cholesterol present in potentially atherogenic lipoprotein particles including LDL-C, lipoprotein a, VLDL-C, VLDL -C). In recent times, its elevation in serum has attracted much attention as a better predictor of cardiovascular risk in comparison with other lipid parameters [14].…”

“…Non-HDL-C defines all cholesterol present in potentially atherogenic lipoprotein particles including LDL-C, lipoprotein a, VLDL-C, VLDL remnant and intermediate-density lipoprotein (IDL-C). In recent times, its elevation in serum has attracted much attention as a better predictor of cardiovascular risk in comparison with other lipid parameters [ 14 ]. In this study, the prevalence of elevated levels of non-HDL-C was 64.3%, with a female preponderance (78.9%) (p < 0.0001) ( Table 3 ).…”

“…People with type 2 diabetes mellitus are prone to developing pro-atherogenic cardiovascular risk factors as a consequence of the inability to control blood glucose and the presence of atherogenic dyslipidemia [ 13 ]. Moreover, non-HDL-C which represents all cholesterol present in potentially atherogenic lipoprotein particles namely, LDL-C, Lipoprotein a, very-low density lipoprotein-cholesterol (VLDL-C), VLDL remnant and intermediate-density lipoprotein (IDL-C) in serum is fast gaining reputation as a predictor of cardiovascular disease in comparison with other lipid parameters [ 14 ]. Previous reports have indicated that patients who achieved the LDL-C management target had residual risk of recurrent coronary artery disease [ 15 ] suggesting that there is more to achieving optimal LDL-C levels.…”