2023
DOI: 10.1136/jcp-2022-208733
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Prevalence of elevated serum concentrations of biotin in patients from South East England, Korea, Singapore and Thailand and risk of immunoassay interference

Sally Brady,
Katharine Bates,
Susan Oddy
et al.

Abstract: Biotin interference in immunoassays using biotin-streptavidin binding technology is well recognised by clinical laboratories, though the prevalence of elevated biotin in patient populations is largely unknown. We determined serum biotin concentrations in 4385 patient samples received sequentially by 6 laboratories for routine immunoassay analysis in England, and Korea, Singapore and Thailand (3 countries within the Asia Pacific region, APAC). Samples were initially analysed using a research use-only immunoassa… Show more

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“…Accordingly, the interference from biotin in a sample can mimic typical pathological constellations of the pituitary and the peripheral hormone in an axis that may lead to wrong diagnoses (see Table 2 ). Most reports in the literature are focus on problems in evaluation of the thyroid axis [ 31 ], but other hormone assays can be affected as well [ 32 ].…”
Section: Analytical Pitfallsmentioning
confidence: 99%
“…Accordingly, the interference from biotin in a sample can mimic typical pathological constellations of the pituitary and the peripheral hormone in an axis that may lead to wrong diagnoses (see Table 2 ). Most reports in the literature are focus on problems in evaluation of the thyroid axis [ 31 ], but other hormone assays can be affected as well [ 32 ].…”
Section: Analytical Pitfallsmentioning
confidence: 99%