Prevalence of Enuresis and Daytime Urinary Incontinence in Children and Adolescents With Sickle Cell Disease

Abstract

There is a significant association between sickle cell disease and enuresis and overactive bladder symptoms such as daytime incontinence, urgency and frequency. Thus, all children and adolescents with sickle cell disease should be questioned regarding the presence of these symptoms to facilitate treatment for these conditions.

Nocturnal Enuresis in Children and Adolescent with Sickle cell Anemia

“…This is similar to what had been reported in normal children with NE [26][27][28]. Only two studies further divided NE into monosymptomatic (MNE) and nonmonosymptomatic(NMNE) [9,19]. MNE was reported in 42-48.2% and NMNE was present in 51.8%-58% of children with NE.…”

“…Primary nocturnal enuresis was the comments reported type, it occurred in 75.5-86% of patients [11,15,19]. This is similar to what had been reported in normal children with NE [26][27][28].…”

“…The prevalence rate of NE in children with SCA decreases with increasing age from 29.7% at age 4-8 years to 9% at age 18-20 years ( Figure 1) [6,9,10,12,16,17,19,20]. A similar trend was also observed in enuretic normal children [26][27][28][29][30].…”

“…SCA were retrieved after thorough literature search (Table 1A-1C) [4,[6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25]. We categorized these articles in 3 groups according to the criteria used to define NE.…”

“…Group 3 (Table 1c): These are the studies that used different diagnostic criteria, they reported a prevalence rate of 32.2%-68.9% [4,[16][17][18][19][20][21][22][23][24][25].…”