Prevalence of Epstein-Barr virus in oral squamous cell carcinoma, oral lichen planus, and normal oral mucosa

Sand, Lars; Jalouli, Jamshid; Larsson, Per‐Göran; Hirsch, Jan‐Michaél

doi:10.1067/moe.2002.124462

Cited by 108 publications

(118 citation statements)

References 40 publications

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“…Stress and anxiety may form a starting point for the initiation of autoimmune reactions [64], although stress could also be consequent to OLP and not vice versa [65]. Other viral infections, such as EpsteinBarr virus [66,67] and torque teno virus [68,69], are also more prevalent among OLP patients than in healthy controls.…”

Section: Case-control Studymentioning

confidence: 98%

The magnitude of the association between hepatitis C virus infection and oral lichen planus: meta-analysis and case control study

et al. 2011

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Although hepatitis C virus (HCV) infection is associated with oral lichen planus (OLP), a case-control study and a meta-analysis were designed to investigate the magnitude of such an association. A total of 413 presumptive OLP patients (18-75 years) who referred to a dental clinic in Rasht (Iran) were consecutively selected. OLP was diagnosed clinically (typical forms) and histologically (atypical forms) by a calibrated examiner. A total of 487 adults (20-77 years) attending the same dental clinic were the controls. The two groups were homogeneous in terms of age, gender and occupation. Subjects were tested for anti-HCV antibodies. The odds ratio (OR) for OLP attributable to HCV infection was non-significant [OR 1.2, 95% confidence interval (95CI) 0.3-4.8], suggesting that the association between HCV and OLP was weak in the Iranian context. Meta-analysis of observational studies characteristics of primary studies were that cases were diagnosed clinically (only typical forms) and histologically and exposure was assessed through anti-HCV antibodies. Exposed/unexposed cases/controls were extracted and zero values were appropriately transformed. As much as 44 studies, including the present, were located. Publication bias could not be totally excluded. The pooled OR, estimated using the random-effect model, was 2.8 (95CI 2.4-3.2). Sensitivity analysis confirmed the robustness of results. Subgroup analysis showed non-significant differences between American/European and Asian/African studies. The fraction of global OLP cases associated with HCV (population attributable fraction) was 2.1% (95CI 1.9-2.2%). Although HCV and OLP were significantly associated, the majority of OLP patients were not affected by HCV.

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Section: Case-control Studymentioning

confidence: 98%

The magnitude of the association between hepatitis C virus infection and oral lichen planus: meta-analysis and case control study

et al. 2011

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“…A hipótese de associação viral na etiologia do CEC é reforçada pelo fato da maioria da população ser exposta cronicamente aos agentes químicos cancerígenos presentes no tabaco e álcool, e mesmo assim apenas uma pequena minoria de usuários desses agentes desenvolvem o CEC. Apesar do EBV ser um vírus com grande potencial oncogênico e estar frequentemente presente na cavidade bucal, apenas uma pequena porção de EBV associados às lesões evoluem para câncer; assim reforçando uma hipótese de que o EBV combinado aos agentes químicos está envolvido no desenvolvimento do CEC [14][15][16] . O carcinoma de nasofaringe é um CEC com alta ocorrência no sudeste asiático e no sul da China, com uma malignidade mais acentuada nos pacientes de sexo masculino.…”

Section: Epstein-barr Vírusunclassified

O Papel do Epstein Barr Vírus na Carcinogênese Oral

Ferreira¹,

Demathé²,

Bernabé³

et al. 2012

Odonto

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RESUMOIntrodução: o carcinoma espinocelular (CEC) é o câncer de cabeça e pescoço de maior ocorrência, representando cerda de 90% de todos esses tumores. O CEC apresenta diversos fatores de risco, como fumo, álcool, e alguns vírus de potencial oncogênico, entre eles o Epstein Barr vírus (EBV) que é um membro da família Herpesviridae e apresenta um tropismo por linfócitos B e também por células epiteliais. Objetivo: realizar um levantamento na literatura da presença do EBV em carcinomas orais. Conclusão: o EBV está intimamente relacionado com carcinoma de nasofaringe, um CEC de alta ocorrência no sudeste asiático, no entanto o seu papel nos demais CEC orais ainda não foi comprovado. Palavras-chave:Infecções por Vírus Epstein-Barr. Neoplasias Bucais. Carcinoma de Células Escamosas. Carcinoma. ABSTRACTIntroduction: the squamous cell carcinoma (SCC) is the head and neck cancer of higher occurrence, representing about 90% of all these tumors. The SCC has several risk factors as smoking, alcohol and some oncogenic viruses, including the Epstein Barr virus (EBV). The EBV is a member of Herpesviridae family and has tropism for B lymphocytes and also for epithelial cells. Aim: the aim of this study was accomplish a review of the literature about the presence of the EBV in oral carcinomas. Conclusion: EBV is closely related to nasopharyngeal carcinoma, a SCC of high incidence in Southeast Asia, however its role in others oral SCC has not been proved.

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“…48 OLP has been found to be associated with various viral agents such as human papilloma virus (HPV), Epstein Barr virus (EBV), human herpes virus 6 (HHV-6) and human immunodeficiency virus (HIV). [55][56][57] Epidemiological evidences from various studies worldwide strongly suggest that hepatitis C virus (HCV) may be an etiologic factor in OLP. [58] In OLP, HCV replication has been reported in the epithelial cells from mucosa of LP lesions by reverse transcription/polymerase chain reaction or in-situ hybridization; also, HCV-specific CD4 and CD8 lymphocytes were reported in the subepithelial band.…”

Section: Infectious Agentsmentioning

confidence: 99%

Clinical and Genetic Aspects of Oral Lichen Planus

Haqiqi

Pourmoshir

Bereshneh

2016

Int J of Biomed & Adv Res

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Lichen planus (LP) is a chronic inflammatory muco-cutaneous disease. Oral Lichen Planus (OLP) is often asymptomatic; the atrophic-erosive form can cause symptoms ranging from burning sensation to severe pain, interfering with speaking, eating, and swallowing. OLP can be a source of severe morbidity and has a small potential to be malignant. The prevalence of OLP varies from 0.5% to 4% of the general population and in spite of extensive research; exact etiology of OLP remains unclear. A proper understanding of the clinical presentation, pathogenesis and diagnosis of the disease becomes important for providing the right treatment. The present review draws together aspects of Epidemiology, Clinical Features, Etiopathogenesis with emphasis on Genes involved in OLP pathogenesis and the clinical management of OLP.

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Prevalence of Epstein-Barr virus in oral squamous cell carcinoma, oral lichen planus, and normal oral mucosa

Cited by 108 publications

References 40 publications

The magnitude of the association between hepatitis C virus infection and oral lichen planus: meta-analysis and case control study

The magnitude of the association between hepatitis C virus infection and oral lichen planus: meta-analysis and case control study

O Papel do Epstein Barr Vírus na Carcinogênese Oral

Clinical and Genetic Aspects of Oral Lichen Planus

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