Prevalence of erectile dysfunction among Chinese men with type 2 diabetes mellitus

Yang, Guoqing; Chen, Pan; Lu, Juming

doi:10.1038/ijir.2010.21

Cited by 43 publications

(47 citation statements)

References 57 publications

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“…In conclusion, the results of the current study demonstrated that the HbA1c level was a risk factor for diabetic ED, while the TT level was a protective factor, which was the same as a previous result; however, the BMI, FPG, TC and TG did not show a correlation with diabetic ED (4,21,22,(29)(30)(31). These results may have been caused by the small sample size.…”

Section: Discussioncontrasting

confidence: 47%

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Clinical significance and expression of microRNA in diabetic patients with erectile dysfunction

Jiang¹,

Luo²,

Zhao³

et al. 2015

Experimental and Therapeutic Medicine

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Abstract. The aim of the present study was to investigate the expression of microRNA (miR)-93, miR-320 and miR-16 and to assess their diagnostic value in diabetic patients with erectile dysfunction (ED). A total of 120 individuals were divided into three groups, which included the diabetics with ED group (ED group), the diabetics without ED group (NED group) and the healthy volunteers group (control group). Each group included 40 individuals. Serum samples were collected and reverse transcription quantitative polymerase chain reaction detection of the three types of miRNA was performed and the sensitivity of ED was analyzed by receiver operating characteristic curves. A negative correlation was identified between the incidence of ED in patients with diabetes and serum total testosterone levels (r=0.302, P<0.05); however, a positive correlation was observed between the incidence of ED in diabetics and the HbA1c level (r=0.231, P<0.05). Additionally, the relative expression levels of the three types of miRNA were higher in the ED group when compared with the NED and control groups (P<0.05). When compared with the control group, the area under the curve (AUC) values for miR-93, miR-320 and miR-16 were 0.793, 0.818 and 0.810, respectively, in the ED group and 0.576, 0.532 and 0.542 in the NED group, respectively. Furthermore, when compared with the NED group, the AUC value for miR-93, miR-320 and miR-16 was 0.707, 0.810 and 0.833, respectively, in the ED group. Therefore, the expression levels of miR-93, miR-320 and miR-16 may be useful for the early diagnosis of ED in patients with diabetes.

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Section: Discussioncontrasting

confidence: 47%

“…The risk factors of diabetic ED include high HbA1c levels, a high BMI, insulin resistance and angiopathy (4,21,22). Diabetic macroangiopathy, microangiopathy and endothelial dysfunction are all involved in the pathophysiological progression of ED.…”

Section: Discussionmentioning

confidence: 99%

Clinical significance and expression of microRNA in diabetic patients with erectile dysfunction

Jiang¹,

Luo²,

Zhao³

et al. 2015

Experimental and Therapeutic Medicine

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“…ED is a common complication of type 2 DM, and certain risk factors are associated with the presence of ED and severity (18). Age-adjusted incidence of complete ED has been found to be 3-fold higher in men with DM than in men without DM (19).…”

Section: Discussionmentioning

confidence: 99%

Is there a relationship between severity of coronary artery disease and severity of erectile dysfunction?

et al. 2013

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Introductıon:The correlation between erectile dysfunction (ED) and coronary artery disease has been emphasized and ED has been recognized as a potential independent risk factor and/or predictor of coronary artery disease (CAD). We evaluated the association between the number of occluded coronary arteries in myocardial infarction (MI) patients with the severity of ED, and investigated the influence of related risk factors in our study group. Materials and Methods: 183 male patients who underwent coronary angiography because of acute MI from November 2009 to May 2011 were included. Following the stabilization of patients after the treatment, each patient was evaluated for erectile functionality. Risk factors such as age, diabetes, smoking, waist circumference, hypertension, and hematologic parameters were recorded. Results: Among 183 patients with a mean age of 55.2 years who underwent coronary angiography due to acute MI, 100 (54.64%) had ED, while the ED rate was 45.36% (44/97) in cases of single-vessel disease, 64.5% (31/48) in cases of two-vessel disease, and 65.7% (25/38) in cases of three-vessel disease. The mean IIEF score was 24.2 ± 4.3, 20.4 ± 4.9 and 20.5 ± 4.2 for single or two or three-vessel disease, respectively. The presence of hypertension aggravated ED only in patients with three-vessel disease and increased total and LDL cholesterol levels in patients with single-vessel or two-vessel disease were accompanied by significantly decreasing IIEF scores. Conclusıon: The severity of ED correlated with the number of occluded vessels documented by coronary angiography, in male patients with acute myocardial infarction. In addition, the presence of hypertension had a significant influence over erectile function only in patients with three-vessel occlusion.

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“…Over 50% of men with DM develop ED. [5][6][7] In humans, DM is associated with stenosis and occlusion of IPA, which can compromise blood inflow to the corpora cavernosa and, consequently, impair erectile function. 8,9 Abnormalities in IPA are found in 36.7% of diabetic patients.…”

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confidence: 99%

Internal Pudental Artery Dysfunction in Diabetes Mellitus Is Mediated by NOX1-Derived ROS-, Nrf2-, and Rho Kinase–Dependent Mechanisms

et al. 2016

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E rectile dysfunction (ED) is characterized by the inability to develop or maintain penile erection during sexual activity.1 In healthy subjects, penile erection depends on highly coordinated responses, involving relaxation of the pre-and intrapenile vasculature, leading to increased penile blood flow, increased intracavernosal pressure, and penile tumescence. 2,3 Arterial blood flow to the corpus cavernosum originates from the internal iliac arteries, courses to the internal pudendal arteries (IPA), and terminates in the bilateral cavernous arteries. Functional and structural changes in the IPA lead to ED. 4 Diabetes mellitus (DM) is an important risk factor for ED. Over 50% of men with DM develop ED. [5][6][7] In humans, DM is associated with stenosis and occlusion of IPA, which can compromise blood inflow to the corpora cavernosa and, consequently, impair erectile function. 8,9 Abnormalities in IPA are found in 36.7% of diabetic patients. 10 Although it may be expected that IPA display DM-associated dysfunction, 11 almost no studies have addressed the function of IPA in DM. 12 Hyperglycemia, hyperlipidemia, and inflammation, 3 main metabolic abnormalities in DM, induce reactive oxygen species (ROS) generation and oxidative stress. Oxidative stress, defined as a disturbance in the production of ROS or in the ability of the antioxidant defenses to neutralize ROS, is critically involved in DM-associated complications, including nephropathy, cardiomyopathy, endothelial dysfunction, and ED. 6,[13][14][15] Nicotinamide adenine dinucleotide phosphate-oxidase (NADPH oxidase) is the main source of ROS in the vasculature. Seven NADPH oxidase isoforms have been identified (NOX1-5, Duox1, Duox2), 16 with nicotinamide adenine dinucleoride phosphate oxidase 1 (NOX1) playing an important role in vascular smooth muscle cell (VSMC) proliferation, migration, and extracellular matrix production.17 IncreasedAbstract-Oxidative stress plays an important role in diabetes mellitus (DM)-associated vascular injury. DM is an important risk factor for erectile dysfunction. Functional and structural changes in internal pudendal arteries (IPA) can lead to erectile dysfunction. We hypothesized that downregulation of nuclear factor E2-related factor 2 (Nrf2), consequent to increased nicotinamide adenine dinucleotide phosphate oxidase 1 (NOX1)-derived reactive oxygen species (ROS), impairs IPA function in DM. IPA and vascular smooth muscle cells from C57BL/6 (control) and NOX1 knockout mice were used. DM was induced by streptozotocin in C57BL/6 mice. Functional properties of IPA were assessed using a myograph, protein expression and peroxiredoxin oxidation by Western blot, RNA expression by polymerase chain reaction, carbonylation by oxyblot assay, ROS generation by lucigenin, nitrotyrosine, and amplex red, and Rho kinase activity and nuclear accumulation of Nrf2 by ELISA. IPA from diabetic mice displayed increased contractions to phenylephrine (control 138.5±9.5 versus DM 191.8±15.5 Nuclear factor E2-related factor 2 (Nrf2) is the mai...

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Prevalence of erectile dysfunction among Chinese men with type 2 diabetes mellitus

Cited by 43 publications

References 57 publications

Clinical significance and expression of microRNA in diabetic patients with erectile dysfunction

Clinical significance and expression of microRNA in diabetic patients with erectile dysfunction

Is there a relationship between severity of coronary artery disease and severity of erectile dysfunction?

Internal Pudental Artery Dysfunction in Diabetes Mellitus Is Mediated by NOX1-Derived ROS-, Nrf2-, and Rho Kinase–Dependent Mechanisms

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