Prevalence of esophageal atresia among 18 international birth defects surveillance programs

Abstract

BACKGROUND-The prevalence of esophageal atresia (EA) has been shown to vary across different geographical settings. Investigation of geographical differences may provide an insight into the underlying etiology of EA.

A cross-sectional nationwide survey on esophageal atresia and tracheoesophageal fistula

“…The aetiology is still unknown but environmental and/or genetic factors have been suggested [1][2][3]. The epidemiology of EA has been shown to vary in reported series with prevalence raging from 1:2500 to 1:4500 live births [1][2][4][5][6][7][8][9][10][11]. The most frequently encountered variant (75-90% of cases) is EA with distal TEF, type C according to Gross classification [1,7,10,[11][12][13].…”

“…The aetiology is still unknown but environmental and/or genetic factors have been suggested [1][2][3]. The epidemiology of EA has been shown to vary in reported series with prevalence raging from 1:2500 to 1:4500 live births [1][2][4][5][6][7][8][9][10][11].…”

Postoperative Complications and Functional Outcome after Esophageal Atresia Repair: Results from Longitudinal Single-Center Follow-Up

“…1 International prevalence rates of EA/TEF currently range between 1.27 and 4.55 per 10,000 births. [2][3][4] Due to the complex nature and infrequency of cases, EA/TEF management remains a major therapeutic challenge for most pediatric surgeons and other involved specialists. 5,6 In most of the current reports, prematurity, low birth weight, and additional congenital anomalies are associated with higher mortality and further complicate the care of these patients, 7,8 whereas survival rates in full-term infants with no other abnormalities can approach 100% after EA/TEF surgery.…”

Microdeletion 11q13.1.q13.2 in a patient presenting with developmental delay, facial dysmorphism, and esophageal atresia: Possible role of the GSTP1 gene in esophagus malformation

“…It affects 1:4,220 live births (Nassar et al, 2012). Its mode of inheritance and pathophysiology are complex (Jacobs et al, 2012).…”