Prevalence of esophageal eosinophilia in patients referred for diagnostic upper gastrointestinal endoscopy

Abstract

Background and Aim: Esophageal eosinophilia such as gastro-esophageal reflux disease (GERD) and eosinophilic esophagitis (EoE) are associated with several conditions. Esophagus eosinophilic infiltration characterized the Eosinophilic esophagitis (EoE). The purpose of the present study was to determine the esophageal eosinophilia prevalence in patients underwent diagnostic upper gastrointestinal endoscopy. Patients and Methods: This cross-sectional study was carried out on 96 male adult patients underwent upper gastrointestinal endoscopy for unexplained upper GI symptoms in the department of Hepatology & Gastroenterology and Faculty of Medicine, DHQ Hospital Haripur KPK and Type-D Hospital Jamrud District Khyber from June 2022 to November 2022. Patient age>16 years with upper GI symptoms such as nausea, upper abdominal pain, dysphagia, vomiting, and heart burn referred for upper GI endoscopy were enrolled. Individual’s history, demographic details, physical examination, clinical details, laboratory tests such as serum creatinine, CBC, upper GI endoscopy, differential leucocytic count, liver biochemical tests, biopsy, and biopsy staining for histopathological examination were recorded. Data analysis was done in SPSS version 27. Results: Of the total 96 patients, incidence of Esophageal eosinophilia (EE), EoE, and low-grade esophageal eosinophilia was 33.3% (n=32), 5.2% (n=5), and 29.2% (n=28) respectively.