Prevalence of exposure to pharmacogenetic drugs by the Saudis treated at the health care centers of the Ministry of National Guard

Alshabeeb, Mohammad A.; Alyabsi, Mesnad; Paras, Bien

doi:10.1016/j.jsps.2022.06.013

Saudi Pharmaceutical Journal

2022

DOI: 10.1016/j.jsps.2022.06.013

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Prevalence of exposure to pharmacogenetic drugs by the Saudis treated at the health care centers of the Ministry of National Guard

Mohammad A. Alshabeeb

Mesnad Alyabsi²,

Bien Paras³

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2023

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Cited by 2 publications

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Interethnic Differences in Drug Response: Projected impact of Genetic Variations in the Saudi Population

Alsultan,

Alalwan,

Alshehri

et al. 2023

Pharmacogenomics

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Ethnicity is known to have an impact on drug responses. This is particularly important for drugs that have a narrow therapeutic window, nonlinearity in pharmacokinetics and are metabolized by enzymes that demonstrate genetic polymorphisms. However, most clinical trials are conducted among Caucasians, which might limit the usefulness of the findings of such studies for other ethnicities. The representation of participants from Saudi Arabia in global clinical trials is low. Therefore, there is a paucity of evidence to assess the impact of ethnic variability in the Saudi population on drug response. In this article, the authors assess the projected impact of genetic polymorphisms in drug-metabolizing enzymes and drug targets on drug response in the Saudi population.

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Interethnic Differences in Drug Response: Projected impact of Genetic Variations in the Saudi Population

Alsultan,

Alalwan,

Alshehri

et al. 2023

Pharmacogenomics

View full text Add to dashboard Cite

show abstract

Risperidone Pharmacogenetics: The Impact of Star Alleles' Predicted Phenotypes on Global Safety in Autistic Children

Shilbayeh,

Adeen,

Alhazmi

et al. 2023

International J. of Pharmacology

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Prevalence of exposure to pharmacogenetic drugs by the Saudis treated at the health care centers of the Ministry of National Guard

Cited by 2 publications

References 59 publications

Interethnic Differences in Drug Response: Projected impact of Genetic Variations in the Saudi Population

Interethnic Differences in Drug Response: Projected impact of Genetic Variations in the Saudi Population

Risperidone Pharmacogenetics: The Impact of Star Alleles' Predicted Phenotypes on Global Safety in Autistic Children

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