Prevalence of Eyelid Laxity and its Association with Ophthalmic Findings and Disease Severity in Patients with Keratoconus

Naderan, Mohammad; Jahanrad, Ali; Farjadnia, Mahgol

doi:10.5301/ejo.5000937

Cited by 9 publications

(6 citation statements)

References 20 publications

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“…Keratoconus has been associated with atopia, 11, 12 vernal keratoconjunctivitis, 13-15 and environmental factors such as persistent eye rubbing and eyelid laxity. 16, 17 There is a higher prevalence of keratoconus in patients with Downs syndrome; 18 however, the genetic correlation has not been conclusive and the presence of keratoconus in these patients is likely associated to persistent eye rubbing. Other genetic conditions such as Leber’s congenital amaurosis 19 and mitral valve prolapse 1, 20, 21 have been genetically linked to Keratoconus, and numerous publications show a strong genetic predisposition, 22-24 with identified potential linked genes.…”

Section: Keratoconus: Epidemiologymentioning

confidence: 99%

Corneal Cross-Linking for Pediatric Keratcoconus Review

Perez-Straziota

Gaster

Rabinowitz

2018

Cornea

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Studies of cross-linking in pediatric patients are sparse, with relatively short follow-up times, and mostly on small groups of patients. Treatment with cross-linking halts progression of keratoconus in the pediatric population, and early treatment seems to be cost-effective compared with later penetrating keratoplasty. Long-term effects and regression rates remain unclear, and further studies are needed in this population.

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Section: Keratoconus: Epidemiologymentioning

confidence: 99%

Corneal Cross-Linking for Pediatric Keratcoconus Review

Perez-Straziota

Gaster

Rabinowitz

2018

Cornea

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“…В связи с этим пациенты предъявляют разнооб разные жалобы, такие как постоянное покраснение глаза, ощущение инородного тела в глазу, дискомфорт, слизистое отделяемое, не поддающиеся консервативному лечению. Помимо вышеперечисленных признаков, имеются данные о других офтальмологических проявлениях, к которым относится патология роговицы: кератоконус [9][10][11][12], аномалии положения векзаворот/выворот ниж них век, частичный блефароптоз [7,13,14], птоз ресниц, глаукома [15]. СГВ также часто ассоциируется с системными заболеваниями, среди них чаще всего встречаются ожирение, гипертоническая болезнь, ишемическая болезнь сердца, сахарный диабет и синдром обструктивного апноэ сна (СОАС) [16][17][18][19].…”

Section: обоснованиеunclassified

Biomechanical properties of the cornea in Floppy eyelid syndrome

Krinitsyna¹,

Grusha²

2022

Journal of Clinical Practice

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Purpose: To determine corneal biomechanical properties in patients with floppy eyelid syndrome Methods: The study included 40 patients (54 eyes) with hyper-extensible eyelid syndrome. The average age was 53.9 6.7 years. The central corneal thickness averaged 551 25. All patients underwent standard ophthalmological examination, including pneumotonometry. Intraocular pressure (IOP) and biomechanical properties of the cornea were measured using dynamic bidirectional applanation. Results: Study of the biomechanical properties of the cornea in patients with Floppy eyelid syndrome showed a decrease in corneal hysteresis (CH) indices on average to 9.96 0.61 mm Hg, corneal resistance factor (CRF) - to 9.54 0.64 mm Hg. Moreover, their value varied depending on the severity of the syndrome. The mean value of corneal compensated IOP (IOPcc) in the entire sample was 15.5 1.0 mm Hg, Goldman IOP (IOPg) 15.1 2.0 mm Hg, pneumotonometric IOP 11,61 2.9 mm Hg. Regardless of the severity, the pneumotonometric IOP indices did not have statistically significant differences, while as this syndrome progressed, the IOPcc and IOPg indices showed a steady decrease in the mean values. Conclusions: It was found that in the Floppy eyelid syndrome the biomechanical parameters of the cornea were reduced. At the same time, the value of these indicators varied significantly from the severity. The largest decrease was demonstrated by the corneal hysteresis index, and the smallest corneal-compensated IOP.

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“…Floppy eyelid syndrome (FES) is characterised by a thin, rubbery upper tarsus that can be folded upon itself and easily everted with upward traction due to abnormal eyelid and tarsal laxity, accompanied by diffuse reactive palpebral papillary conjunctivitis with or without the presence of symptoms of ocular surface inflammation [158]. It can lead to significant ocular irritation and its coexistence with keratoconus has been well reported in the literature [159][160][161]. Many studies have found a significantly higher level of FES in KC patients (up to 71%) [161,162].…”

Section: (D) Release Of Inflammatory Mediatorsmentioning

confidence: 99%

“…It can lead to significant ocular irritation and its coexistence with keratoconus has been well reported in the literature [159][160][161]. Many studies have found a significantly higher level of FES in KC patients (up to 71%) [161,162]. The mechanism, though, behind its contribution to the pathogenesis/progression of keratoconus remains unknown.…”

Section: (D) Release Of Inflammatory Mediatorsmentioning

confidence: 99%

“…In addition, FES is associated with dry eye disease with symptoms that tend to be chronic, worse in the morning and refractory to dry eye treatments. Objective tools for dry eye evaluation have been found decreased in people with eyelid hyperlaxity, including tear film break-up time, increased corneal staining, increased Meibomian gland dropout, abnormal meibum quality and decreased Schirmer test scores [161].…”

Section: (D) Release Of Inflammatory Mediatorsmentioning

confidence: 99%

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Tear Film and Ocular Surface in Keratoconus

Hamada

Matsou

2021

Keratoconus

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Keratoconus (KC) is an ectatic corneal disorder, characterised by progressive stromal thinning and structural weakening with apical cone-like protrusion, leading to progressive myopia, irregular astigmatism, scarring and decreased vision. It is a leading cause of corneal transplantation in the developed world. While keratoconus has been traditionally considered a predominantly degenerative, non-inflammatory disease of multivariate origin, the exact aetiology remains largely unknown. There is now evidence of genetic inheritance and possible association with systemic disease, as well as substantial evidence that certain environmental factors, such as ocular surface disease, atopy and contact lens wear, and behaviours, such as excessive eye rubbing, may play a key role. The factors that determine or affect the progression or stabilisation of the disease are not well characterised or understood.A number of studies suggest a pivotal role of inflammation in the pathogenesis and progression of KC, contradicting the dogma that traditionally classified keratoconus as a non-inflammatory condition. Elevated levels of inflammatory mediators, such as pro-inflammatory cytokines, tumour necrosis factor, interleukins, cell adhesion molecules, and matrix metalloproteinases (MMPs) have been detected in keratoconic eyes compared to normal, implying that chronic inflammatory events are involved in the manifestation and progression of the disease. Many studies have attempted to investigate in depth the pathogenesis of keratoconus. And while it is widely accepted that complex interactions between genetic and environmental factors, both mechanical and biochemical, influence the development and course of

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Prevalence of Eyelid Laxity and its Association with Ophthalmic Findings and Disease Severity in Patients with Keratoconus

Abstract: Higher prevalence and greater eyelid laxity were found in patients with KC compared to healthy participants. However, eyelid laxity was not associated with severity of KC.

Cited by 9 publications

References 20 publications

Corneal Cross-Linking for Pediatric Keratcoconus Review

Corneal Cross-Linking for Pediatric Keratcoconus Review

Biomechanical properties of the cornea in Floppy eyelid syndrome

Tear Film and Ocular Surface in Keratoconus

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