Prevalence of Factor V Leiden-G1691A and MTHFR-C677T Thrombosis Gene Modifier in Iron Deficiency Anemia: A Pathophysiological Effect in Indian Isolates

Abstract

Normal iron levels are required to prevent thrombocytosis by inhibiting thrombopoiesis. Thrombocytosis is usually associated with a mild iron deficiency and is the result of a lack of inhibition of thrombopoiesis. Study participants were 430 iron deficiency anemia (IDA) patients. Ten (10) mL of venous blood were collected for the subjects. Ferritin analysis was done by ELISA method while Hemogram analysis was done by auto-analyzer. Factor V Leiden, PRTG20210A, and MTHFR C677T genotype analysis was performed by PCR-RFLP method. Among the patients, 9 were heterozygous (G[A) and 2 were homozygous (A[A) carrier of FV Leiden; while 20 were heterozygous (C[T) and 3 were homozygous (T[T) for MTHFR polymorphism. None of the patient was identified with PT mutation. Patients with thrombosis gene marker had lower hemoglobin, mean corpuscular volume, mean corpuscular haemoglobin levels, and mean corpuscular hemoglobin concentration than patients without thrombosis gene marker. Serum ferritin was elevated in subject with the absence of thrombosis gene markers. Our data suggest a high impact of inherited hypercoagulability risk factors in the pathogenesis of IDA and its complications.

Frequency of the C677T Polymorphism of MTHFR, G20210A of Prothrombin and R506Q of Factor V Leiden in Type 2 Diabetics in Abidjan

“…This observation is . In Pandya's study, patients with iron-deficiency anemia and the C677T genetic marker for thrombosis had lower hemoglobin levels and hematimetric constants compared to those without the genetic marker [47]. This avenue should be explored in order to determine whether anemia, and in particular iron-deficiency anemia could be used to search for a C677T mutation in diabetics.…”

Burden of Inherited Hematological Disorders in Population of Vindhyan Region, Madhya Pradesh

“…Kol, Baiga, Pasi, and Khairbar are the representative tribes of Vindhyan region of Madhya Pradesh. Few literature available that depict the burden of Thalassemia, Sickle cell disease, HFE, Xmn1, Factor V, MTHFR, HMOX1, UGT1A1 and GST genetic mutation in these population of Vindhyan region [1][2][3][4][5]. Genetic testing of various hematological inherited diseases is necessary in the mentioned population to avoid the inheritance of homozygous condition.…”