Prevalence of fasciolosis in livestock and humans: A systematic review and meta-analysis in Iran

Khademvatan, Shahram; Majidiani, Hamidreza; Khalkhali, Hamidreza; Taghipour, Ali; Asadi, Negar; Yousefi, Elham

doi:10.1016/j.cimid.2019.05.001

Cited by 27 publications

(26 citation statements)

References 61 publications

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“…38 However, studies in areas with lower prevalence may fail to show a correlation between livestock and human infection rates. [54][55][56] The distribution of fascioliasis by sex shows variable results. A large study by Parkinson et al in the Bolivian Altiplano involving almost 8000 subjects of all ages failed to find a significant association with sex.…”

Section: Epidemiologymentioning

confidence: 99%

<p>Human Fascioliasis: Current Epidemiological Status and Strategies for Diagnosis, Treatment, and Control</p>

Caravedo¹,

Cabada²

2020

RRTM

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Purpose of the Review: This review aims to critically assess current knowledge about the epidemiology, diagnosis, and management of Fasciola infection in humans. Recent Findings: Fascioliasis is an emerging neglected zoonotic infection affecting the health and wellbeing of human populations. The burden of infection is unclear, and studies have shown the geographic expansion of fascioliasis in human and livestock likely related to climate change. The infection can be asymptomatic or present in acute or chronic forms. Regardless of the presentation, fascioliasis can be associated with long-term complications such as anemia and malnutrition. Early in the infection, antibody testing is the only tool available for diagnosis confirmation. In the chronic forms serology and stool microscopy are helpful. Other tests such as antigen detection and PCR-based methods including isothermal tests have shown promising results. Triclabendazole is the only drug available to treat Fasciola infection. However, reports of resistant infections in livestock and human threaten the clinical care and control of the infection in endemic areas. Summary: Fascioliasis is an emerging infection around the world with an uncertain burden. Lack of standardization of diagnostic testing and treatment alternatives hinder treatment and control of the infection.

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Section: Epidemiologymentioning

confidence: 99%

<p>Human Fascioliasis: Current Epidemiological Status and Strategies for Diagnosis, Treatment, and Control</p>

Caravedo¹,

Cabada²

2020

RRTM

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“…At present, the northern, northwestern, and western regions of Iran appear to be most suitable for completion of the Fasciola spp. life cycle [34,35,12]. Spatial analysis con rmed that northwest Iran was a high prevalence region for fascioliasis.…”

Section: Discussionmentioning

confidence: 89%

“…[10,11]. A systematic review estimated a fascioliasis pooled prevalence of 6.2% (95% CI: 5.8-6.5%) in Iranian livestock, with prevalence values of 3.1% (95% CI: 2.4-3.7%) in goats, 4.2% (95% CI: 3.8-4.5%) in sheep, and 9.0% (95% CI: 8.0-9.9%) in cattle [12]. In northern Iran, large-scale human fascioliasis occurred in 1989 that was the onset of the rst largest outbreak of human fascioliasis in the world, involving up to 10000 individuals in Guilan Province.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Helminth Infections Identified in Slaughtered Livestock in Iran, 2015-2019

Kiani¹,

Budke²,

Abadi³

et al. 2020

Preprint

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Introduction: Helminth infections of livestock can result in considerable economic losses. This study aims to evaluate the spatial frequency of cystic echinococcosis (CE), dicrocoeliasis, and fascioliasis in livestock slaughtered in Iran during the years 2015-2019 and estimate direct costs associated with organ condemnation due to these parasites.Methods: Abattoir data from all 31 Iranian provinces were collected from the Iran Veterinary Organization. Infection prevalence was calculated per year at the province level. The Local Moran's I statistic was performed to evaluate spatial autocorrelation of animals positive at slaughter for the years 2015-2019. Direct costs associated with condemned livers were calculated for each parasitic condition. Results: Overall prevalence values for the study timeframe were as follows: sheep and goat fascioliasis (1.5%, 910,282/58,393,349), cattle fascioliasis (3.8%, 23,3175/6,038,419), sheep and goat dicrocoeliasis (4.6%; 270,1274/58,393,349), cattle dicrocoeliasis (3.1%; 186,009/6,038,419), sheep and goat CE (5.3%; 3,108,767/58,393,349), and cattle CE (7.2%; 438,534/6,038,419). Northwestern Iran had the highest prevalence of CE and fascioliasis. High infection areas for Dicrocoelium spp. included the provinces of Zanjan, Gilan, Qazvin, and Tehran, which are located in northern Iran. Direct economic losses for sheep and goat fascioliasis, dicrocoeliasis, and CE for the study period were US$13,841,826, US$41,768,472, and US$22,801,296, respectively. Direct economic losses for cattle fascioliasis, dicrocoeliasis, and CE for the study period were US$1,989,582, US$1,669,289, and US$2,656,535, respectively.Conclusion: Our findings provide valuable data for future monitoring of these important parasitic diseases in Iranian livestock. Disease control strategies are required to reduce the economic and public health impact of these helminths.

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“…A study report that, 101 chronic cases from the Andean region and many endemic areas: 48% had eosinophilia above normal levels (Alban et al, 2002). According to the studies, it did not become certain whether there exists any difference between genders for the prevalence of fascioliasis (Khademvatan et al 2019). In one of the studies, it was reported that parasitosis were more frequent in females and statistically significant differences were observed between genders (Tas Cengiz et al 2015).…”

Section: Discussionmentioning

confidence: 98%

“…However, this disease is often characterized by fever, abdominal pain, and eosinophilia. (Furst et al 2012;Khademvatan et al 2019;Mas-Coma et al 2005). Hydatidosis caused by the larval form of Echinococcus granulosus can be life-threatening and nonspecific clinic signs.…”

Section: Introductionmentioning

confidence: 99%

The Importance of Eosinophilia in The Early Diagnosis of Fascioliasis, Toxocariasis and Hydatidosis

2020

JHMN

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Helminthiasis, especially in tissue-mediated are the most common cause of persistent eosinophilia. However, these finding neglected and misdiagnosed. This study aims to determine the seroprevalence of fascioliasis, hydatidosis, and toxocariasis in eosinophilic patients and to demonstrate diagnostic criteria of eosinophilia in the early diagnosis of the three parasitic diseases. The study was conducted between March 2015

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Prevalence of fasciolosis in livestock and humans: A systematic review and meta-analysis in Iran

Cited by 27 publications

References 61 publications

<p>Human Fascioliasis: Current Epidemiological Status and Strategies for Diagnosis, Treatment, and Control</p>

<p>Human Fascioliasis: Current Epidemiological Status and Strategies for Diagnosis, Treatment, and Control</p>

Evaluation of Helminth Infections Identified in Slaughtered Livestock in Iran, 2015-2019

The Importance of Eosinophilia in The Early Diagnosis of Fascioliasis, Toxocariasis and Hydatidosis

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