Prevalence of fatal adverse drug reactions in hospitalized patients

Pardo-Cabello, Alfredo José; Contreras, Lily; Gamero, Mario; Jiménez, Francisco; Cañas, Emilio Puche

doi:10.5414/cpp47596

Cited by 27 publications

(3 citation statements)

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“…Additionally, there is a significant under‐reporting of ADRs, even serious and severe, to spontaneous reporting systems in hospitals and general practices 5 . Observational studies that screen cases systematically have reported the incidence of fatal ADRs to be between 0.02% and 0.74% of the hospital admissions and 3.0% and 18.4% of all death cases 4,6–9 …”

Section: Introductionmentioning

confidence: 99%

“…5 Observational studies that screen cases systematically have reported the incidence of fatal ADRs to be between 0.02% and 0.74% of the hospital admissions and 3.0% and 18.4% of all death cases. 4,[6][7][8][9] While the types of fatal ADRs vary, fatal haemorrhages and cytostatic-induced myelosuppression have been common in many studies. [6][7][8][9][10][11][12][13] According to the WHO database, antineoplastic/immunomodulating drugs are the most frequently involved drug class causing fatal ADRs globally.…”

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confidence: 99%

“…4,[6][7][8][9] While the types of fatal ADRs vary, fatal haemorrhages and cytostatic-induced myelosuppression have been common in many studies. [6][7][8][9][10][11][12][13] According to the WHO database, antineoplastic/immunomodulating drugs are the most frequently involved drug class causing fatal ADRs globally. 14 These drugs were most frequently found also in previous studies in Finland.…”

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confidence: 99%

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Drug‐related deaths in a university hospital: Comparison to previous decades

Kauppila,

Backman,

Niemi

et al. 2023

Basic Clin Pharma Tox

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The incidence of fatal adverse drug reactions (ADRs) in hospitals varies widely and ADRs are often underreported. The impact of medical safety processes is not easily evaluated and although medical practice changes constantly, little is known about ADR trends. This study concentrated on the current incidence and properties of fatal ADRs occurring in a university hospital and compared the results with two previous studies performed in the same hospital. We investigated retrospectively all 1236 deaths that occurred during 2019 in the Helsinki University Hospital. All the cases were evaluated by a team of experts and the causality was assessed using the categories by World Health Organization and Uppsala monitoring centre. Suicides were excluded. Among death cases, we identified 65 certain or probable ADR cases (5.3%), representing 0.011% of all hospital admissions. Cytostatics and antithrombotics remained the largest drug classes, with neutropenia or sepsis and bleedings as the most common fatal ADRs. Compared to our earlier studies, warfarin caused less, and direct oral anticoagulants caused more fatal bleedings, reflecting the drug usage among the population. In contrast to earlier studies, contrast media and insulin did not cause any fatal ADRs, which may reflect an improvement in pharmacovigilance awareness among healthcare workers.

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Section: Introductionmentioning

confidence: 99%