Prevalence of fluoroquinolone-resistant and broad-spectrum cephalosporin-resistant community-acquired urinary tract infections in Rio de Janeiro: Impact of   genotypes ST69 and ST131

da-Silva, Ana Paula de Souza; Sousa, Viviane Santos de; Longo, Luís Guilherme de Araújo; Caldera, Saharai; Baltazar, Isabel Cristina Lemos; Bonelli, Raquel Regina; Santoro‐Lopes, Guilherme; Riley, Lee W.; Moreira, Beatriz Meurer

doi:10.1016/j.meegid.2020.104452

Cited by 22 publications

(17 citation statements)

References 29 publications

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“…12 Similarly, a latest research from Brazil investigated the prevalence of ESBL among uropathogenic E. coli isolated from cases of CAUTIs during November 2015 and they found that 41 (8%) isolates produced ESBL. 13 Lucia Boix-Palop, et al reported that the prevalence of ESBL-KP from COUTIs caused by K. pneumoniae increased from 2.4% in 2010 to 10.3% in 2014 in Spain. 14 The high prevalence of ESBL-producing isolates will limit and reduce the treatment choices for COUTIs.…”

Section: Discussionmentioning

confidence: 99%

Etiology and prevalence of ESBLs in adult community-onset urinary tract infections in East China: A prospective multicenter study

Quan

Dai

Liao

et al. 2021

Journal of Infection

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Section: Discussionmentioning

confidence: 99%

Etiology and prevalence of ESBLs in adult community-onset urinary tract infections in East China: A prospective multicenter study

Quan

Dai

Liao

et al. 2021

Journal of Infection

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“…[13] Studies utilizing genotyping methods have found that the majority of community-onset urinary tract infection caused by ESBL-E. coli are caused by major pandemic E. coli lineages belonging to speci c sequence types, including ST131 and ST69. [9,10,29] This may point to common-source exposures in the community. There is mounting evidence that infection with ESBL-E. coli is associated with international travel, particularly to South Asian countries, and food habits, including eating meat contaminated with ESBL-E. coli.…”

Section: Discussionmentioning

confidence: 99%

“…Increasing prevalence of ESBL-E. coli in community-onset and healthcare onset/associated infections is now observed worldwide. [4,10,12,[18][19][20][21][22] A 2019 CDC report showed a 50% increase in hospital-and community-onset infections caused by ESBL-producing Enterobacteriaceae between 2012 and 2017 in the US. [2] A report from the Study for Monitoring Antimicrobial Resistance Trends (SMART) found prevalence of urinary tract infections caused by ESBL-E. coli to increase from 7.8-18.3% between 2010 and 2014 in the US, particularly among hospital-associated infections.…”

Section: Discussionmentioning

confidence: 99%

“…[3][4][5][6][7][8] Recent hospitalization and prior antibiotic use are major drivers of ESBL-E. coli infections, but factors unrelated to healthcare are increasingly recognized, including international travel and consumption of meat contaminated with ESBL-E. coli. [9][10][11][12][13][14] However, most studies compare infection with ESBL-E. coli to infection with drug-susceptible E. coli to assess risk for ESBL-E. coli infections. [11] As such, identi ed risks may determine infection with antimicrobial resistant E. coli and not necessarily ESBL-E. coli.…”

Section: Introductionmentioning

confidence: 99%

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Trends in Prevalence of Extended-Spectrum Beta-Lactamase-Producing Escherichia Coli Isolated From Patients With Community- And Healthcare-Associated Bacteriuria: Results From 2014 To 2020 In An Urban Safety-Net Healthcare System

Raphael

Glymour

Chambers

2021

Preprint

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BackgroundThe prevalence of infections caused by extended-spectrum beta-lactamase producing Escherichia coli (ESBL-E. coli) is increasing worldwide, but the setting in which this increase is occurring is not well defined. We compared trends and risk factors for ESBL-E. coli bacteriuria in community vs healthcare settings.MethodsWe collected electronic health record data on all patients with E. coli isolated from urine cultures in a safety-net public healthcare system from January 2014 to March 2020. All analyses were stratified by healthcare-onset/associated (bacteriuria diagnosed > 48 hours after hospital admission or in an individual hospitalized in the past 90 days or in a skilled nursing facility resident, N=1,277) or community-onset bacteriuria (all other, N=7,751). We estimated marginal trends from logistic regressions to evaluate annual change in prevalence of ESBL-E. coli bacteriuria among all bacteriuria. We evaluated risk factors using logistic regression models.ResultsESBL-E. coli prevalence increased in both community-onset (0.91% per year, 95% CI: 0.56%, 1.26%) and healthcare-onset/associated (2.31% per year, CI: 1.01%, 3.62%) bacteriuria. In multivariate analyses, age >65 (RR 1.88, CI: 1.17, 3.05), male gender (RR 2.12, CI: 1.65, 2.73), and Latinx race/ethnicity (RR 1.52, CI: 0.99, 2.33) were associated with community-onset ESBL-E. coli. Only male gender (RR 1.53, CI: 1.03, 2.26) was associated with healthcare-onset/associated ESBL-E. coli.ConclusionsESBL-E. coli bacteriuria frequency increased at a faster rate in healthcare-associated settings than in the community between 2004 to 2020. Male gender was associated with ESBL-E. coli bacteriuria in both settings, but additional risks—age >65 and Latinx race/ethnicity—were observed only in the community.

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“…(37) E. coli (4.8) Klebsiella spp. (46.2) E. coli (36) E. coli (33.6) E. coli (35) E. coli (34.2) [ 29 ] Brazil 2015 Surveillance study E. coli (499) 8 5 NA 30 20 [ 30 ] Escherichia coli E. coli , Klebsiella pneumoniae K. pneumoniae , Klebsiella oxytoca K. oxytoca, Enterobacter cloacae E. cloacae , Citrobacter freundii C. freundii , Citrobacter koseri C. koseri , Pseudomonas aeruginosa P. aeruginosa , Proteus mirabilis P. mirabilis , Proteus vulgaris P. vulgaris , Serratia marcescens S. marcescens , Serratia fonticola S. fonticola , Morganella morgannii M. morgannii , Providencia rettgeri P. rettgeri , NA Not available …”

Section: Introductionmentioning

confidence: 99%

Oral Antibiotics in Clinical Development for Community-Acquired Urinary Tract Infections

2021

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The treatment of urinary tract infections (UTIs) has been complicated by the emergence of multidrug-resistant, b-lactamase-expressing pathogens. As a result of the limited treatment options, patients often require hospitalization and intravenous therapy. In essence, a strong unmet need for oral antibiotics, active against extended-spectrum b-lactamase (ESBL) uropathogens has emerged. Oral carbapenems (tebipenem and sulopenem) and oral cephalosporin/b-lactamase inhibitor combinations are in various stages of clinical development for the treatment of uncomplicated and complicated UTI. Tebipenem, if approved, will be the first oral treatment for complicated UTI while sulopenem will be for uncomplicated UTI. The b-lactamase inhibitors ETX0282, VNRX7145, ARX1796, and QPX7728 are combined with cefpodoxime proxetil or ceftibuten that achieve favorable exposures in urine compared to other uropathogen-active oral cephalosporins.The combination ceftibuten-QPX7728 has potential broad-spectrum coverage against carbapenemase producers including metallo b-lactamase producers. Other novel combinations, namely cefpodoxime/ETX0282, ceftibuten/VNRX-7145, and ceftibuten/ ARX1796, have also demonstrated excellent activity against Klebsiella pneumoniae carbapanemase (KPC) and OXA-48-like producers. All these agents, upon their arrival for commercial use, would strengthen the outpatient therapy.

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Prevalence of fluoroquinolone-resistant and broad-spectrum cephalosporin-resistant community-acquired urinary tract infections in Rio de Janeiro: Impact of genotypes ST69 and ST131

Cited by 22 publications

References 29 publications

Etiology and prevalence of ESBLs in adult community-onset urinary tract infections in East China: A prospective multicenter study

Etiology and prevalence of ESBLs in adult community-onset urinary tract infections in East China: A prospective multicenter study

Trends in Prevalence of Extended-Spectrum Beta-Lactamase-Producing Escherichia Coli Isolated From Patients With Community- And Healthcare-Associated Bacteriuria: Results From 2014 To 2020 In An Urban Safety-Net Healthcare System

Oral Antibiotics in Clinical Development for Community-Acquired Urinary Tract Infections

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