Prevalence of focal dystonias in the western area of Tottori Prefecture in Japan

Nakashima, Kenichiro; Kusumi, Masayoshi; Inoue, Yuichi; Takahashi, Kentaro

doi:10.1002/mds.870100406

Cited by 86 publications

(84 citation statements)

References 10 publications

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“…Our study compares favorably with several reports using the same methods for case ascertainment [4,6,8,10] . In these studies, the prevalence of focal or focal/segmental dystonia ranged from 61 to 117 per 1,000,000 ( table 1 ).…”

Section: Discussionsupporting

confidence: 70%

Prevalence of Primary Focal or Segmental Dystonia in Adults in the District of Foggia, Southern Italy: A Service-Based Study

et al. 2009

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Background: Primary focal or segmental dystonia is a rare clinical condition including early-onset dystonia, which has the tendency to generalize, and late-onset dystonia, which may be focal or segmental. The prevalence of late-onset dystonia ranges from 30 to 7,320 cases per million, but no data are available in Italy. Methods: A service-based study was conducted in the period 1 January 2001 through 31 December 2002 in the administrative district of Foggia, southern Italy (population 541,653). Cases were traced through hospital discharge diagnosis, botulinum toxin services, day hospital access, ear, nose and throat, ophthalmology and orthopedic surgery specialists, and territorial outpatient services. Inclusion criteria were age 17 years or older, residency in the study area and a diagnosis of primary focal/segmental dystonia. Results: A total of 69 patients were included, giving a crude prevalence of 127.4 per 1,000,000 (women: 146.4; men: 107.0; age 18–34 years: 39.2; 35–54 years: 98.7; 55–74 years: 273.6; 75+ years: 163.3). The standardized rate was 137.5 (95% confidence interval 107.0–174.6). Blepharospasm was the commonest clinical condition (prevalence 68.2), followed by cervical dystonia (prevalence 44.8). Conclusion: The prevalence of primary focal or segmental dystonia in Italy is in keeping with several other reports, but is lower than in studies performed in northern Europe, Minnesota, USA, and Japan. The difference in our results may be mostly explained by misdiagnosis, underascertainment of cases and a fairly limited observation period.

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Section: Discussionsupporting

confidence: 70%

Prevalence of Primary Focal or Segmental Dystonia in Adults in the District of Foggia, Southern Italy: A Service-Based Study

et al. 2009

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“…Compared with our data, Nakashima et al [11] reported a lower prevalence of focal dystonias in the western part of Tottori Prefecture in Japan. These authors suggested that genetic factors may account for the low prevalence compared with the study of Nutt et al [3].…”

Section: Discussioncontrasting

confidence: 55%

Service-Based Survey of Dystonia in Munich

et al. 2002

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We performed a service-based epidemiological study of dystonia in Munich, Germany. Due to favourable referral and treatment patterns in the Munich area, we could provide confident data from dystonia patients seeking botulinum toxin treatment. A total of 230 patients were ascertained, of whom 188 had primary dystonia. Point prevalence ratios were estimated to be 10.1 (95% confidence interval 8.4-11.9) per 100,000 for focal and 0.3 (0.0-0.6) for generalised primary dystonia. The most common focal primary dystonias were cervical dystonia with 5.4 (4.2-6.7) and essential blepharospasm with 3.1 (2.1-4.1) per 100,000 followed by laryngeal dystonia (spasmodic dysphonia) with 1.0 (0.4-1.5) per 100,000.

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“…11 On the basis of this finding, they suggested that primary dystonia represented an underestimated public health concern and that a considerable number of cases in the community remained undiagnosed. 11 Compared with our previous survey, 3 the current survey showed a substantial increase in the prevalence of primary focal dystonias. In Japan, botulinum toxin was introduced to treat blepharospasm in 1997 and to treat spasmodic torticollis in 2001.…”

Section: Discussionmentioning

confidence: 76%

Epidemiology of primary focal dystonias in the western area of tottori prefecture in Japan: Comparison with prevalence evaluated in 1993

2006

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An epidemiological survey of primary focal dystonias in the western area of Tottori Prefecture in Japan was conducted in 2003, and the results were compared with those of a previous survey in 1993. The service-based prevalence of primary focal dystonia was 13.7 per 100,000 population, representing an increase from that found in the 1993 survey. In 1997, botulinum toxin type A was approved for use in Japan to treat blepharospasm, and the increased number of patients now being evaluated and diagnosed with focal dystonias at medical centers throughout Japan may be responsible for this increased prevalence. Prevalence by subtype per 100,000 population was as follows: facial dystonia, 6.5; spasmodic torticollis, 2.0; writer's cramp, 4.4; and other focal dystonias; 0.8. Facial dystonia showed the most marked increase in service-based prevalence among these subtypes.

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Prevalence of focal dystonias in the western area of Tottori Prefecture in Japan

Cited by 86 publications

References 10 publications

Prevalence of Primary Focal or Segmental Dystonia in Adults in the District of Foggia, Southern Italy: A Service-Based Study

Prevalence of Primary Focal or Segmental Dystonia in Adults in the District of Foggia, Southern Italy: A Service-Based Study

Service-Based Survey of Dystonia in Munich

Epidemiology of primary focal dystonias in the western area of tottori prefecture in Japan: Comparison with prevalence evaluated in 1993

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