Prevalence of gastro‐esophageal reflux‐related symptoms in Japanese infants

Miyazawa, Reiko; Tomomasa, Takeshi; Kaneko, Hiroaki; Tachibana, Akira; Ogawa, Tetsushi; Morikawa, Akihiro

doi:10.1046/j.1442-200x.2002.01609.x

Cited by 61 publications

(56 citation statements)

References 10 publications

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“…This prevalence is similar to the one described in the literature, regardless of the diagnostic criteria used, 4,5,[17][18][19][20] suggesting that the use of the Rome Criteria may be useful in identifying infants who do not meet the criteria for IR and who therefore have to be more carefully evaluated.…”

Section: Discussionsupporting

confidence: 81%

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Prevalência de refluxo gastroesofágico patológico em lactentes regurgitadores

Costa¹,

Silva²,

Gouveia³

et al. 2004

J. Pediatr. (Rio J.)

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Objective: To determine the prevalence of pathologic gastroesophageal reflux in a group of regurgitant infants attended at Helena Moura Hospital, Recife, State of Pernambuco, Brazil. The clinical criteria employed were based on Rome II criteria. Method:The study design was transversal. The patients were all children of less than 1 year of age with a history of episodes of regurgitation for at least 3 weeks. The study group was comprised of 798 children who attended the program between January and August of 2002. The diagnostic criteria were based on Rome II criteria.Results: The prevalence of pathologic gastroesophageal reflux was 11.15% (89/798) (95% CI 9.10-13.48). It was higher during the first two trimesters of life, 14.62% (31/212) (95% CI 10.33-19.86) in the first trimester, and 13.76% (38/276) (95% CI 10.07-18.21) in the second trimester. Conclusion:The prevalence of pathologic gastroesophageal reflux within the group of children examined concurred with previously published studies, with predominance, therefore, of regurgitant infants.

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Section: Discussionsupporting

confidence: 81%

“…Authors from different countries 4,6,17,18 have used clinical criteria to detect infants with suspected PGER. The Rome Criteria 10 have not been used frequently to identify infants who suffer from IR, and consequently, those at higher risk for PGER.…”

Section: Introductionmentioning

confidence: 99%

Prevalência de refluxo gastroesofágico patológico em lactentes regurgitadores

Costa¹,

Silva²,

Gouveia³

et al. 2004

J. Pediatr. (Rio J.)

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“…Infants are especially prone to regurgitate and it has been shown that the number of infants with this phenomenon decreases from about 80% during the first month of life to less than 10% at the age of one year [4]. A study by Miyazawa et al on 921 infants showed that over 47% of one-month-old infants have one or more regurgitation or vomiting episodes per day, however this number falls to just 6.4% by the age of seven months [5]. Several factors contribute to exacerbate this phenomenon in the youngest infants, including the sole or predominantly liquid milk-based diet, the recumbent position and the immaturity of the function and structure of the gastro-esophageal junction [6].…”

Section: Evolution and Natural Course Of Regurgitation In The Pediatrmentioning

confidence: 99%

Gastroesophageal Reflux in Children

2017

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Gastro-esophageal reflux (GER) is common in infants and children and has a varied clinical presentation: from infants with innocent regurgitation to infants and children with severe esophageal and extra-esophageal complications that define pathological gastro-esophageal reflux disease (GERD). Although the pathophysiology is similar to that of adults, symptoms of GERD in infants and children are often distinct from classic ones such as heartburn. The passage of gastric contents into the esophagus is a normal phenomenon occurring many times a day both in adults and children, but, in infants, several factors contribute to exacerbate this phenomenon, including a liquid milk-based diet, recumbent position and both structural and functional immaturity of the gastro-esophageal junction. This article focuses on the presentation, diagnosis and treatment of GERD that occurs in infants and children, based on available and current guidelines.

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“…[2][3][4][5] However, published data to support this hypothesis are limited and few available data tend to suggest the contrary to common belief that infant…”

mentioning

confidence: 91%

“…1 It occurs frequently during the first year of life with the peak incidence of 65-86.9% at 1-4 months of age and usually resolves spontaneously by 6 to 12 months of age. [2][3][4][5] Regurgitation may occur in normal infants 6 but may be accompanied by complications such as weight loss, esophagitis, anemia, or stricture; in these situations the infants are defined as having GER disease (GERD). 7 There is a continuum between normal infants with GER and those with GERD, so there is no clear cut-off point separating physiological from pathological reflux.…”

mentioning

confidence: 99%

Natural course of gastroesophageal reflux disease during infancy - six-month follow-up

Hidayati¹,

Firmansyah²,

Tumbelaka³

2007

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Background Very few data have been published about the naturalcourse of gastro-esophageal reflux (GER) symptoms duringinfancy; further, no risk factors of GER disease (GERD) have beenidentified.Objectives To determine the prevalence and natural course ofregurgitation in infancy and factors of gastroesophageal refluxdisease.Methods A cohort of 223 healthy infants who attended IntegratedHealth Services run by local housewife (Posyandu) of Ciputat –suburb of Jakarta – between March and November 2005.Information on subjects’ history of regurgitation and other reflux-related symptoms was obtained by interviewing mother and diaryrecord. Subjects were followed up to age of 1 year irrespective ofthe clinical status.Results At 6 months of age most infants (56.5%) had regurgitation1 to 3 days per week and only 2.7% infants regurgitated daily.Regurgitation 1 to 3 episodes per day was found in 92.8% ofsubjects. The proportion of infants regurgitation decreasedgradually with age; the proportion for the consecutive 6 to 11month was 100%, 65.5%, 33.6%, 14.3%, 3.6% and 1.3%,respectively. At the age of 1 year no infants was found to beregurgitated. Related symptoms included hiccup (58.3%),vomiting (23.3%) and back arching (2.2%). Feeding problemoccurred in 34.1% infants and occurred more likely in infantswho regurgitate daily compared to 4 – 6 day per week (OR 3.5;95%CI 2.2;5.6) and 1 – 3 day per week (OR 1.8; 95%CI 0.6;0.9).Conclusions Regurgitation in infancy disappears spontaneouslywith age. Reflux-related symptoms are hiccup, vomiting and backarching. Feeding problem occurs most likely in infants whoregurgitate daily.

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Prevalence of gastro‐esophageal reflux‐related symptoms in Japanese infants

Abstract: Regurgitation is a common symptom in Japanese infants and decreases spontaneously with age. The natural history of GER must be taken into consideration when deciding the treatment.

Cited by 61 publications

References 10 publications

Prevalência de refluxo gastroesofágico patológico em lactentes regurgitadores

Prevalência de refluxo gastroesofágico patológico em lactentes regurgitadores

Gastroesophageal Reflux in Children

Natural course of gastroesophageal reflux disease during infancy - six-month follow-up

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