Prevalence of gastroduodenal mucosal injury in asymptomatic patients taking antiplatelet agents in Japan

Randomised clinical trial: esomeprazole for the prevention of nonsteroidal anti‐inflammatory drug‐related peptic ulcers in Japanese patients

“…These findings demonstrating an increased risk of upper GI injury with NSAIDs in Western populations mirror those seen in Japanese individuals . Results of a survey conducted by the Japan Rheumatism Foundation, for example, showed that 15.5% of Japanese patients with rheumatoid arthritis who were treated with NSAIDs for 3 months or longer had gastric ulcers, and 1.9% had duodenal ulcers; these rates were 3.8–4.7 times higher than those in the general population .…”

Randomised controlled trial of early magnetically controlled capsule endoscopy for the prevention of gastrointestinal bleeding in patients at high bleeding risk scheduled for percutaneous coronary intervention: MACE-GPS study protocol

“…The OPT-PEACE (Optimal antiplatelet therapy for prevention of gastrointestinal injury evaluated by ANKON magnetically controlled capsule endoscopy) study reported a 23% incidence of gastric ulcers in a population with low-risk bleeding undergoing PCI 8. Furthermore, earlier investigations using standard gastroscopy found that gastrointestinal mucosal damage ranged from 30% to 70% in patients at a high risk of bleeding or with gastrointestinal symptoms who were receiving antiplatelet medication 9–12. Although the benefits of preventing gastrointestinal bleeding are being increasingly recognised and appear promising for improving PCI outcomes, there is still no conclusion as to whether early identification of gastrointestinal conditions in patients at high bleeding risk scheduled for PCI (HBPCI) improves patient outcomes.…”

“…8 Furthermore, earlier investigations using standard gastroscopy found that gastrointestinal mucosal damage ranged from 30% to 70% in patients at a high risk of bleeding or with gastrointestinal symptoms who were receiving antiplatelet medication. [9][10][11][12] Although the benefits of preventing gastrointestinal bleeding are being increasingly recognised and appear promising for improving PCI outcomes, there is still no conclusion as to whether early identification of gastrointestinal conditions in patients at…”

Effect of low-dose aspirin on upper gastrointestinal tract mucosa

“…An increase in L-ASA prescriptions has become a subject of public concern because of its gastrointestinal side effects [1]. An increase in L-ASA prescriptions has become a subject of public concern because of its gastrointestinal side effects [1].…”