Prevalence of Gastrointestinal Symptoms in Chinese Community-Dwelling Adults with and without Diabetes

Sang, Miaomiao; Wu, Tongzhi; Zhou, Xiaoying; Horowitz, Michael; Qiu, Shanhu; Guo, Haijian; Wang, Bei; Wang, Donglei; Rayner, Christopher K.; Sun, Zilin

doi:10.3390/nu14173506

Cited by 5 publications

(3 citation statements)

References 29 publications

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“…Найпоширенішими симптомами були симптоми нижніх відділів ШКТ, зокрема діарея та запор. У цьому дослідженні старший вік (> 65років) асоціювався зі збільшенням ризику виникнення принаймні одного симптому, пов'язаного із ШКТ загалом (p < 0,001), та окремо симптомів верхніх і нижніх відділів ШКТ (р = 0,005 та p = 0,004, відповідно) [25].…”

Section: о в колеснікова а о радченкоunclassified

Modern view on the age-associated gastrointestinal diseases. Review

Kolesnikova¹,

Radchenko²

2022

СГ

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The substantial improvement of diagnostic methods, treatment and preventive measures in recent years resulted in the significant increase in life expectancy, which in turn contributed to an increase in the frequency of chronic noncommunicable diseases among elderly patients. Pathological conditions that are related to the gastrointestinal (GI) tract are an extremely common reason for consultations among patients of all ages, but the elderly people are most prone to the development of GI diseases. Available information regarding which GI changes are normal in older age and which ones are pathologic is limited, and the available data is usually contradictory. The diagnostic algorithm in elderly patients with GI symptoms is even more complicated by the frequent presence of concomitant diseases. In addition, the elderlies usually have atypical manifestations of the GI disease with subtle symptoms; therefore, doctors who are not familiar with It may not diagnose the disease timely. Drug side effects manifested in the GI tract are also a common phenomenon in elderly patients and they can also change the clinical picture and complicate the diagnosis of GI pathologies. Thus, elderly patients represent a population group among whom effective detection and correct diagnosis of GI diseases become extremely difficult for physicians who are not familiar with the features of age‑related changes in the GI tract and peculiarities of GI diseases. Therefore, the expansion of knowledge about the course of GI disorders in this category of patients is absolutely necessary for further improvement of the quality and duration of life of such patients. Our review presents modern data on the prevalence of gastrointestinal tract pathologies, their role in the general morbidity of the population, the most typical disorders of the gastrointestinal tract in elderly patients, the mechanism of drug interactions and side effects of drugs that can cause the development of complications from the GI tract.

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Section: о в колеснікова а о радченкоunclassified

Modern view on the age-associated gastrointestinal diseases. Review

Kolesnikova¹,

Radchenko²

2022

СГ

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“…In addition, DM is prone to gastrointestinal dysfunction. Nearly half suffer from gastrointestinal symptoms, including vomiting, nausea, constipation, diarrhea, fecal incontinence, or abdominal pain ( Selbuz and Buluş, 2020 ; Sang et al, 2022 ). Colonoscopy has been widely used as a valuable tool for screening and treating colorectal diseases in the last 2 decades.…”

Section: Introductionmentioning

confidence: 99%

Impact of glucagon-like peptide 1 receptor agonist liraglutide and dipeptidyl peptidase-4 inhibitor sitagliptin on bowel cleaning and gastrointestinal symptoms in type 2 diabetes

et al. 2023

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Objective: Glucagon-like peptide 1 receptor agonists (GLP-1 RAs) and dipeptidyl peptidase-4 inhibitors (DPP-4i) profoundly affect the gastrointestinal motor system, which may increase the incidence of inadequate bowel cleaning and gastrointestinal symptoms. Hence, this observational study mainly aimed to assess the influence of GLP-1 RAs liraglutide and DPP-4i sitagliptin on bowel preparation in type 2 diabetes (T2DM).Method: This observational study consecutively enrolled T2DM scheduled for a colonoscopy. Participants were prospectively separated into the liraglutide group (n = 120), sitagliptin group (n = 120), and control group (n = 120) based on the current hypoglycemic regimen. 3L split-dose polyethylene glycol regimens were used for bowel preparation. Experienced gastrointestinal endoscopists conducted colonoscopies. Lawrance Bowel-Preparation Tolerability Questionnaire and Boston Bowel Preparation Scale (BBPS) were conducted to assess bowel cleaning quality, tolerability, and safety.Results: The incidence of inadequate bowel cleaning was 17.5% in the liraglutide group, 20.5% in the sitagliptin group, and 21.7% in the control group. The difference among the three groups was not statistically significant (p = 0.927). Meanwhile, there were no significant differences in the mean BBPS, cecal intubation time, and polyp-detecting rates among the three groups (all p > 0.0.05). Nausea, vomiting, and bloating scores were increased in the liraglutide group compared with the other two groups (p < 0.05), whereas most were mild or very mild. Subgroup analyses showed that the incidence of inadequate bowel cleaning in T2DM with diabetic peripheral neuropathy (DPN) was increased in the liraglutide group compared with the sitagliptin group (61.3% vs. 32.1%, p = 0.022) and control group (61.3% vs. 32.8%, p = 0.025).Conclusion: GLP-1RA liraglutide or DPP-4i sitagliptin did not significantly increase the incidence of inadequate bowel cleaning and gastrointestinal symptoms during bowel preparation. Liraglutide may increase the incidence of inadequate bowel preparation in patients with DPN. This study reveal that more attention and aggressive bowel preparation regimens should be given to the T2DM with DPN.Clinical Trial Registration: (https://www.chictr.org.cn/index.aspx), identifier (ChiCTR2200056148).

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“…Para esta discussão destaca-se os resultados que são associados à disbiose intestinal, ou seja as alterações que afetam a microbiota dos pacientes que foram dor abdominal sendo 53,8% (n=7), náuseas e vômitos com 69,2% (n=9), distensão abdominal com 53,8% (n=7), diarreia 61,5% (n=8) e constipação com a incidência de 76,9% (n=10). Na pesquisa realizada porKurniawan et al (2019) relata também a ocorrência de sintomas gastrointestinais em pacientes clínicos diabéticos, onde 33% apresentaram flatulência, 11,4% constipação e 12,5% plenitude pós prandial, sendo este último resultado não contemplado no presente estudo, com os pacientes da clínica de Montes Claros-MG. Já nos estudos realizados porSang et al (2022) feita em Ressalta-se que os estudos acima citados foram realizados em condições que os difere deste em alguns parâmetros, como característica da população, etnia, número de participantes, tipo de questionários utilizados para a avaliação dos sintomas gastrointestinais, idade, dentre outros fatores que contribuem para as diferenças significativas de percentuais. Contudo, é perceptível que os sintomas gastrointestinais são decorrentes em pacientes diabéticos o que, consequentemente, traz desconfortos e afeta a saúde da microbiota intestinal sendo fator preditivo para o desenvolvimento de disbiose intestinal, piorando o estado de saúde dos indivíduos com DM2.…”

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A relação do consumo alimentar e microbiota intestinal em pacientes diabéticos tipo 2 de uma clínica particular de Minas Gerais

Santos,

Souza,

Ferreira

2023

RSD

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O Diabetes Mellitus tipo 2 é uma doença caracterizada por provocar hiperglicemias constantes, complicações metabólicas como, fadiga, poliúria, polidipsia e prejuízos renais e cardiovasculares. Além disso, o portador de Diabetes Mellitus tipo 2 pode sofrer com sintomas gastrointestinais, como diarreia, flatulência, náuseas, vômitos e dores abdominais. É uma condição em crescimento exponencial no mundo e sua causa está relacionada a fatores genéticos e ambientais, como alimentação inadequada e sedentarismo. O objetivo do presente artigo é apresentar uma pesquisa de consumo alimentar e sua relação com a disbiose intestinal em um grupo de pacientes portadores de DM2, a fim de avançar estudos que promovam maior qualidade de vida a esses pacientes acometidos. A amostra foi composta por 13 voluntários, entre 18 a 69 anos, de ambos os gêneros, portadores de Diabetes Mellitus tipo 2, de uma clínica particular de Minas Gerais. Para avaliar os dados, foi utilizado um questionário contemplando dados antropométricos, a Escala de Bristol, o instrumento Gastrointestinal Symptom Rating Scale (GSRS) para verificar a incidência de sintomas gastrointestinais e o Questionário de Frequência Alimentar (QFA). Foi possível verificar que a maioria dos pacientes diabéticos apresentaram sobrepeso ou algum grau de obesidade e também relataram sintomas gastrointestinais, como diarreia, constipação, flatulência, azia, refluxo e náuseas, com o consumo de leite e derivados, frutas, carnes vermelhas e brancas, bolo e pão de queijo e sementes. Sendo assim, a compreensão do padrão alimentar e manejo da sintomatologia é fundamental para a melhoria da qualidade de vida dos pacientes com Diabetes Mellitus tipo 2.

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Prevalence of Gastrointestinal Symptoms in Chinese Community-Dwelling Adults with and without Diabetes

Cited by 5 publications

References 29 publications

Modern view on the age-associated gastrointestinal diseases. Review

Modern view on the age-associated gastrointestinal diseases. Review

Impact of glucagon-like peptide 1 receptor agonist liraglutide and dipeptidyl peptidase-4 inhibitor sitagliptin on bowel cleaning and gastrointestinal symptoms in type 2 diabetes

A relação do consumo alimentar e microbiota intestinal em pacientes diabéticos tipo 2 de uma clínica particular de Minas Gerais

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