Prevalence of genital Chlamydia trachomatis at a Tertiary Care Hospital in North India

Dhawan, Benu; Khullar, Swati; Rawre, Jyoti; Gupta, Somesh; Khanna, Neena

doi:10.4103/ijstd.ijstd_111_22

Cited by 4 publications

(4 citation statements)

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“…In tropical countries like India, where tuberculosis (TB) and other infectious diseases are widespread, the role of infectious diseases in causing infertility becomes a prominent consideration as indicated by several studies [5,[8][9][10]. Genital infections may cause a wide spectrum of conditions like vaginitis, cervicitis, dyspareunia and PID [11,12], endometriosis and other endometrial disorders [5,13], PCOS/PCOD, ovarian atresia or cysts and anovulation [14,15].…”

Section: Introductionmentioning

confidence: 99%

“…Genital infections may cause a wide spectrum of conditions like vaginitis, cervicitis, dyspareunia and PID [11,12], endometriosis and other endometrial disorders [5,13], PCOS/PCOD, ovarian atresia or cysts and anovulation [14,15]. These infections are generally chronic in nature and cause in ammation and irreversible scarring of the reproductive tract leading to sub-fertility, infertility, recurrent abortions, low birth weight, pre-term birth, stillbirth, maternal and infant mortality [5,9,10]. For instance, female genital tuberculosis (FGTB), that may cause ovarian atresia, PCOS/PCOD, fallopian tube and uterine damage, is estimated to be responsible for 6-25% of female infertility cases in India [5,[16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

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A cross-sectional questionnaire-based landscaping of female infertility reveals genital Infections as a major contributor to reproductive tract anomalies, menstrual disorders, and infertility

PATNAIK,

Sarkar,

Jojula

et al. 2023

Preprint

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Purpose Female infertility is a global health concern. The association of genital infections with female infertility is neglected due to their chronic but asymptomatic nature. Lack of routine diagnosis and delay in treatment further causes intractable pathological sequalae and consequential infertility. This study aims to identify the most significant prognostic symptoms of genital infection(s) that correlate strongly with reproductive tract anomalies, menstrual disorders, and infertility. Methods We designed a detailed questionnaire and conducted a cross-sectional study with 100 female subjects, categorized into infertile (n1 = 62) and healthy groups (n2 = 38). The data collected was documented and statistically analysed. Results This study highlights an early onset of infertility (21–30 years). Almost 27% of the infertile female subjects are symptomatic for genital infections and ~ 42% exhibit menstrual irregularities. Polycystic ovarian syndrome/disease (PCOS/PCOD, ~ 30%), are observed to be the most predominant disorders followed by endometrial disorders (~ 10%) and tubal damage (~ 8%) in infertile subjects. A multivariate correlation analysis revealed a highly significant (p ≤ 0.05) and strong association (0.15 < Φ ≤ 1.0) between menstrual disorders, endometrial disorders, uterine/tubal blockage, and hormonal disruption with infection-associated symptoms, such as vaginitis, cervicitis, pelvic inflammatory disorder (PID), dyspareunia, tuberculosis (TB), urinary tract infection (UTI). Conclusions Our study reveals genital infections to be a significant contributor to female infertility. The questionnaire designed here offers a useful tool for self or clinical assessment and may help in timely prognosis/diagnosis of genital infections which may contribute to improved management of reproductive health and fertility.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A cross-sectional questionnaire-based landscaping of female infertility reveals genital Infections as a major contributor to reproductive tract anomalies, menstrual disorders, and infertility

PATNAIK,

Sarkar,

Jojula

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…In tropical countries like India, where tuberculosis (TB) and other infectious diseases are widespread, the role of infectious diseases in causing infertility becomes a prominent consideration as indicated by several studies [5,[8][9][10]. Genital infections is the author/funder, who has granted medRxiv a license to display the preprint in (which was not certified by peer review) preprint…”

Section: Introductionmentioning

confidence: 99%

“…The copyright holder for this this version posted September 6, 2023. ; https://doi.org/10.1101/2023.09.04.23295020 doi: medRxiv preprint (sexually transmitted, postpartum, post-abortion infections and secondary infections e.g., TB) may cause a wide spectrum of conditions like vaginitis, cervicitis, dyspareunia and PID [11,12], endometriosis and other endometrial disorders [5,13], PCOS/PCOD, ovarian atresia or cysts and anovulation [14,15]. These infections are generally chronic in nature and cause inflammation and irreversible scarring of the reproductive tract leading to sub-fertility, infertility, recurrent abortions, low birth weight, pre-term birth, stillbirth, maternal and infant mortality [5,9,10]. For instance, female genital tuberculosis (FGTB) is estimated to be responsible for 6-25% of female infertility cases in India [5,[16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

A cross-sectional questionnaire-based landscaping of female infertility reveals genital Infections as a major contributor to reproductive tract anomalies, menstrual disorders, and infertility

Patnaik,

Sarkar,

Jojula

et al. 2023

Preprint

View full text Add to dashboard Cite

ObjectivesFemale infertility is a global health concern. The association of genital infections with female infertility is neglected due to their chronic but asymptomatic nature. Lack of routine diagnosis and delay in treatment further causes intractable pathological sequalae and consequential infertility. This study aims to identify the most significant prognostic symptoms of genital infection(s) that correlate strongly with reproductive tract anomalies, menstrual disorders, and infertility.MethodsWe designed a detailed questionnaire and conducted a cross-sectional study with 100 female subjects, categorized into infertile (n1 = 62) and healthy groups (n2 = 38). The data collected was documented and statistically analyzed.ResultsThis study highlights an early onset of infertility (21-30 years). Almost 27% of the infertile subjects are symptomatic for genital infections and ∼42% exhibit menstrual irregularities. Polycystic ovarian syndrome/disease (PCOS/PCOD, ∼30%), are observed to be the most predominant disorders followed by endometrial disorders (∼10%) and tubal damage (∼8%) in infertile subjects. A multivariate correlation analysis revealed a highly significant (p≤ 0.05) and strong association (0.15 < Φ ≤ 1.0) between menstrual disorders, endometrial disorders, uterine/tubal blockage, and hormonal disruption with infection-associated symptoms, such as vaginitis, cervicitis, pelvic inflammatory disorder (PID), dyspareunia, tuberculosis (TB), urinary tract infection (UTI), sperm, and semen abnormalities.ConclusionsOur study reveals genital infections to be a significant contributor to female infertility. The questionnaire designed here offers a useful tool for self or clinical assessment and may help in timely prognosis/diagnosis of genital infections which may contribute to improved management of reproductive health and fertility.SynopsisThe study reveals impact of genital infections on female infertility and offers a comprehensive questionnaire-based tool for an early self/clinical prognosis of infection induced infertility.

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Yadav,

Singh,

Dhawan

et al. 2024

IJDVL

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Prevalence of genital Chlamydia trachomatis at a Tertiary Care Hospital in North India

Cited by 4 publications

References 5 publications

A cross-sectional questionnaire-based landscaping of female infertility reveals genital Infections as a major contributor to reproductive tract anomalies, menstrual disorders, and infertility

A cross-sectional questionnaire-based landscaping of female infertility reveals genital Infections as a major contributor to reproductive tract anomalies, menstrual disorders, and infertility

A cross-sectional questionnaire-based landscaping of female infertility reveals genital Infections as a major contributor to reproductive tract anomalies, menstrual disorders, and infertility

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