Prevalence of Gestational Diabetes in Triplet Pregnancies: A Retrospective Cohort Study and Meta-Analysis

Hager, Marlene; Ott, Johannes; Castillo, Deirdre Maria; Springer, Stephanie; Seemann, Rudolf; Pils, Sophie

doi:10.3390/jcm9051523

Cited by 9 publications

(9 citation statements)

References 67 publications

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“…We use GPower 3.1.9.760 with 0.90 power and significance at two-sided α of 0.05 to estimate the smallest difference in maternal or neonatal complication rate between GDM with optimal glycaemic control and suboptimal control to be at 15%, the required sample size is 312 (104 cases and 208 control). For another estimation, the required sample size to estimate 10% (as the lowest possible proportion among all the risk factors) either the history of PCOS with the reported prevalence rate 12.6%30 or multiple pregnancies with reported incidence of 12%–30% among GDM women32 33 with the power 0.90 and α 0.05 at two tails is 263. Taking into consideration about 10% of incomplete or missing data in the home-based records, the sample size needed is 292 (263/0.90) cases and 584 (526/0.90) control at the ratio of 1:2.…”

Section: Methods and Analysismentioning

confidence: 99%

“…Multiple pregnancies is associated with higher risk for GDM due to a higher weight gain rather than the number of fetus 31. The rate of multiple pregnancy deliveries among GDM women in Malaysia range approximately from 12% to 30% 32 33. Many GDM studies have excluded multiple pregnancies in their eligibility criteria, so the risk of multiple pregnancies on GDM is not clear.…”

Section: Introductionmentioning

confidence: 99%

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Study protocol on risk factors for the diagnosis of gestational diabetes mellitus in different trimesters and their relation to maternal and neonatal outcomes (GDM-RIDMAN)

et al. 2022

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IntroductionGestational diabetes mellitus (GDM) is often associated with adverse pregnancy outcomes. However, the association of risk factors with GDM diagnosis, maternal and neonatal health outcomes is less established when compared with women without GDM. We aim to examine the diagnostic accuracy of the conventional and novel risk factors for a GDM diagnosis and their impact on maternal and neonatal health outcomes.Methods and analysisThis retrospective cohort and nested case–control study at six public health clinics is based on medical records and questionnaire survey of women between 2 and 12 months postpartum. The estimated required sample size is 876 complete records (292 cases, 584 control, at a ratio of 1:2). Oral glucose tolerance test results will be used to identify glucose dysregulation, and maternal and neonatal outcomes include maternal weight gain, pre-eclampsia, polyhydramnios, mode of delivery, preterm or postdate birth, complications in labour, birth weight, gestational age at birth, Apgar score, congenital anomaly, congenital hypothyroidism, neonatal death or stillbirth, hypoglycaemia and hyperbilirubinaemia. Psychosocial measures include the WHO Quality of Life: brief, mother–infant bonding (14-item Postpartum Bonding Questionnaire and 19-item Maternal Postnatal Attachment Scale), anxiety (7-item Generalised Anxiety Disorder), depression (9-item Patient Health Questionnaire) and stress (Perceived Stress Scale symptoms) questionnaires. The comparative incidences of maternal and neonatal health outcomes, the comparative prevalence of the psychosocial outcomes between women with GDM and without GDM, specificity, sensitivity, positive and negative predictive values of the risk factors, separately and combined, will be reported. All GDM risk factors and outcomes will be modelled using multivariable regression analysis and the receiver operating characteristics curve will be reported.Ethics and disseminationThis study was approved by the Malaysia Research and Ethics Committee, Ministry of Health Malaysia. Informed consent will be obtained from all participants. Findings will be submitted for publications in scientific journals.

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Section: Methods and Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Study protocol on risk factors for the diagnosis of gestational diabetes mellitus in different trimesters and their relation to maternal and neonatal outcomes (GDM-RIDMAN)

et al. 2022

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“…Other group of researchers from Austria also analyzed the GDM prevalence in triplet pregnancies. The rate was absolutely higher (31.7%) than in singleton pregnancies [ 138 ].…”

Section: Europementioning

confidence: 99%

Evolution of Gestational Diabetes Mellitus across Continents in 21st Century

Dłuski

Ruszała

Rudziński

et al. 2022

IJERPH

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Over the last few decades, several definitions of gestational diabetes mellitus (GDM) have been described. There is currently not enough research to show which way is the best to diagnose GDM. Opinions differ in terms of the optimal screening and diagnostic measures, in part due to the differences in the population risks, the cost-effectiveness considerations, and the lack of an evidence base to support large national screening programs. The basic method for identifying the disease is the measurement of glucose plasma levels which may be determined when fasting, two hours after a meal, or simply at any random time. The currently increasing incidence of diabetes in the whole population, the altering demographics and the presence of lifestyle changes still require better methods of screening for hyperglycemia, especially during pregnancy. The main aim of this review is to focus on the prevalence and modifications to the screening criteria for GDM across all continents in the 21st century. We would like to show the differences in the above issues and correlate them with the geographical situation. Looking at the history of diabetes, we are sure that more than one evolution in GDM diagnosis will occur, due to the development of medicine, appearance of modern technologies, and the dynamic continuation of research.

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“…Obstetricians should choose appropriate instruments and be familiar with the procedure to reduce the operating time. It was reported that P r e p r i n t multiple pregnancy is a risk factor for gestational diabetes mellitus and hypertension [1,11,12]. A meta-analysis [11] showed that 7.3-12.4% of pregnant women with triplets had gestational diabetes mellitus.…”

Section: Discussionmentioning

confidence: 99%

Maternal and fetal benefits of fetal reduction in triplet pregnancies

Zhang

et al. 2023

Arch Med Sci

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IntroductionTriplet pregnancy is a type of high-risk pregnancy that often results in premature delivery. Although fetal reduction is recommended, a number of factors can lead to triplet pregnancies without reduction. As there is no consensus on reduction, it is necessary to carry out a specific evaluation of the benefits of reduction in triplet pregnancy. This study was performed to evaluate and discuss the prognosis of triplet pregnancy with or without fetal reduction.Material and methodsClinical data from 24 women with triplet pregnancies were retrospectively collected and analyzed. Twelve women underwent fetal reduction (fetal reduction group) and 12 women continued triplet pregnancy (non-fetal reduction group). In the fetal reduction group, four dichorionic triamniotic triplets were reduced to dichorionic diamniotic twins (with a reduction of one of the monochorionic diamniotic fetuses); six trichorionic triamniotic triplets were reduced to dichorionic diamniotic twins (with a reduction of one monochorionic monoamniotic fetus).ResultsThere were significant differences in the incidence of premature rupture of membranes and neonatal hypoglycemia between the reduction and non-reduction groups. The average birth weight was significantly different between the reduction group and non-reduction group. The Apgar score was significantly different between the monochorionic monoamniotic reduction group and monochorionic diamniotic reduction group.ConclusionsTriplet pregnancy should be closely monitored throughout pregnancy and the perinatal period, regardless of fetal reduction. The chorionicity should be considered with fetal reduction. Compared with the mother, the remaining fetuses may benefit more from fetal reduction, especially in terms of neonatal weight.

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Prevalence of Gestational Diabetes in Triplet Pregnancies: A Retrospective Cohort Study and Meta-Analysis

Cited by 9 publications

References 67 publications

Study protocol on risk factors for the diagnosis of gestational diabetes mellitus in different trimesters and their relation to maternal and neonatal outcomes (GDM-RIDMAN)

Study protocol on risk factors for the diagnosis of gestational diabetes mellitus in different trimesters and their relation to maternal and neonatal outcomes (GDM-RIDMAN)

Evolution of Gestational Diabetes Mellitus across Continents in 21st Century

Maternal and fetal benefits of fetal reduction in triplet pregnancies

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