Prevalence of Glaucoma in the Wroclaw Population. The Wroclaw Epidemiological Study

Niżankowska, Maria Hanna; Kaczmarek, Radosław

doi:10.1080/09286580500212904

Cited by 34 publications

(43 citation statements)

References 28 publications

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“…This hypothesis was supported by Alvarado et al, who reported elevated level of oxidative damage in glaucomatous TM cells in comparison to controls [17]. Nizankowska and Kacz- marek suggested that progressive neuronal death that is characteristic for glaucomatous optic nerve change may be associated with oxidative stress [18]. Our previous study supported the hypothesis that oxidative stress may play an important role in POAG development.…”

Section: Discussionsupporting

confidence: 89%

The role of the 148 Asp/Glu polymorphism of the APE1 gene in the development and progression of primary open angle glaucoma development in the Polish population

Cuchra¹,

Szaflik²,

Przybyłowska-Sygut³

et al. 2013

pjp

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Glaucoma is an ocular disorder that is characterized by progressive degeneration of the optic nerve and loss of visual field (VF). Recent data have suggested that the level of oxidative DNA damage in human trabecular meshwork is significantly increased in glaucomatous patients as compared to controls. It was also noted that progressive loss of visual field may by connected with elevated levels of oxidative DNA lesions. This hypothesis may suggest the role of an inefficient base excision repair pathway in primary open angle glaucoma (POAG) pathogenesis. The aim of the study was to evaluate the association of the 148 Asp/Glu APE1 gene polymorphism with the risk of POAG development. One hundred fifty patients with POAG and 190 controls were enrolled in our study. Gene polymorphisms were analyzed by PCR-CTPP. We did not observe a statistically significant difference between the frequencies of alleles and genotypes of the 148 Asp/Glu APE1 gene polymorphism in POAG patients and controls. However, the presented study indicated that 148 Asp/Glu of the APE1 gene was associated with decreased risk of progression of POAG with reference to the parameter VF. We suggest that the 148 Asp/Glu APE1 gene polymorphism may decrease the risk of POAG progression.

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Section: Discussionsupporting

confidence: 89%

The role of the 148 Asp/Glu polymorphism of the APE1 gene in the development and progression of primary open angle glaucoma development in the Polish population

Cuchra¹,

Szaflik²,

Przybyłowska-Sygut³

et al. 2013

pjp

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“…The reason for this investigation was that non-population-based public glaucoma screening is frequently organised in different communities, and recent data suggest that by combining different diagnostic methods and/or criteria, the accuracy and the positive likelihood ratio of the screening can be significantly increased. 13,14 However, as the prevalence of glaucoma in the adult Caucasian general population is far below the value optimal for screening, [2][3][4][5][6][7] it is very desirable to increase the prevalence of glaucoma among the self-recruited screening participants. 11,13 To specifically motivate persons to attend who have a high probability of having the disease, information on the risk factors for glaucoma needs to be provided when the screening event is publicised in the media.…”

Section: Discussionmentioning

confidence: 99%

“…1 The prevalence of chronic open-angle glaucoma is approximately 1.5-3% in Caucasians over 40 years of age. [2][3][4][5][6][7] As chronic open-angle glaucoma develops without clinical symptoms, it frequently happens that progression to the stage of severe damage may occur before the patient becomes aware of the disease. Even in the developed countries, it is estimated that 50% of glaucoma sufferers remain undetected.…”

Section: Introductionmentioning

confidence: 99%

Health anxiety in a non-population-based, pre-publicised glaucoma screening exercise

Holló

Kóthy

Géczy

et al. 2009

Eye

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Objective To investigate whether anxiety plays a role in self-recruitment for non-population-based glaucoma screening. Methods In a non-population-based pre-publicised trial, self-recruited Caucasian participants were screened for glaucoma, and also completed the Trait Anxiety Inventory and Shortened Health Anxiety Inventory questionnaires. In pre-publicity for the trial, information on risk factors for glaucoma was given. Participants classified as possible glaucoma cases later underwent a detailed glaucoma investigation. Results Of the 120 total participants (72 females, 48 males), 12 were considered glaucoma suspects at the screening, although only three (2.5%) were ultimately diagnosed with glaucoma. Health anxiety showed significant correlation with trait anxiety (r ¼ 0.525, Po0.001). Trait anxiety was similar for both the genders; this score was significantly below the normal Hungarian population value in women (Po0.001) and at the normal population level in men (P ¼ 0.560). In contrast, health anxiety was significantly higher than for both the 'normal' and 'anxious' reference groups (Po0.001), although smaller than that for hypochondriacs (Po0.001). Participants with pre-existing ocular symptoms, and those who attended because of fear of blindness, had significantly higher trait-and health-anxiety scores (Po0.05 for all comparisons). Conclusion In this screening trial, the health anxiety of the self-recruited participants was significantly above normal, whereas the prevalence of glaucoma was within the usual range for a Caucasian population. This suggests that providing pre-publicity information on risk factors for glaucoma does not necessarily increase the prevalence of glaucoma among self-recruited participants in non-population-based screening, as some individuals may participate on account of elevated health anxiety, rather than because of higher potential risk for glaucoma.

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“…Glaucoma is the most common cause of blindness, and the leading cause of irreversible blindness worldwide [5,6]. Primary open angle glaucoma (POAG) is the most common type of glaucoma.…”

Section: Introductionmentioning

confidence: 99%

The role of Cat -262C/T, GPX1 Pro198Leu and Sod1+35A/C gene polymorphisms in a development of primary open-angle glaucoma in a Polish population

Malinowska¹,

Kowalski²,

Szaflik³

et al. 2016

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The development of glaucoma may be connected with a long-term exposure to oxidative stress caused by free radical (ROS). The main aim of this work was an analysis of associations of Cat-262C/T, GPX1 Pro198Leu and SOD1 35 A/C gene polymorphisms of antioxidant enzymes with a risk of open-angle glaucoma (POAG) in a Polish population. DNA samples collected from 209 patients with POAG and 191 healthy controls were used in this study. Polymorphisms were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). We found that the +35A/C polymorphisms of SOD1 were not associated with a risk of POAG. We found that C/T genotype (1-GPX1Pro198Leu, 2-Cat C262T) is associated with increased risk of open angle glaucoma (1-OR = 2.24; 95% CI: 1.46-3.44; p = 0.0001, 2-OR = 2.16; 95% CI: 1.35-3.34; p = 0.001). We also found that T/T genotype is a risk factor for progression of POAG (1-OR = 3.86; 95% Cl: 1.36-10.96; p = 0.007, 2-OR = 6.37; 95% CI: 1.39-29.28; p = 0.007). Finally our data suggest that gene polymorphisms of GPX1 Pro198Leu and CAT C262T may have a protective role in the development of primary open-angle glaucoma in a Polish population.

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Prevalence of Glaucoma in the Wroclaw Population. The Wroclaw Epidemiological Study

Abstract: The prevalence of the different types of glaucoma was similar to that found in other white populations. Among the subjects examined, 79 had various forms of glaucoma and 71% of them had not previously been diagnosed. Undiagnosed glaucoma is a serious public health problem in Poland.

Cited by 34 publications

References 28 publications

The role of the 148 Asp/Glu polymorphism of the APE1 gene in the development and progression of primary open angle glaucoma development in the Polish population

The role of the 148 Asp/Glu polymorphism of the APE1 gene in the development and progression of primary open angle glaucoma development in the Polish population

Health anxiety in a non-population-based, pre-publicised glaucoma screening exercise

The role of Cat -262C/T, GPX1 Pro198Leu and Sod1+35A/C gene polymorphisms in a development of primary open-angle glaucoma in a Polish population

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