Prevalence of Glucose Intolerance Among Native Hawaiians in Two Rural Communities

Grandinetti, Andrew; Chang, Healani K.; Mau, Marjorie K.; Curb, J. David; Kinney, Ebonie K.; Sagum, R; Arakaki, Richard

doi:10.2337/diacare.21.4.549

Cited by 60 publications

(59 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These findings contrast somewhat with the NHHR project's earlier report that age-adjusted prevalence of glucose intolerance was not significantly associated with Native Hawaiian ancestry. 16 There are several possible explanations for this apparent contradiction. In our earlier report, collapsing of continuous variables (fasting and 2 h glucose concentrations) into a single categorical variable (glucose tolerance status) may have resulted in a loss of statistical information and a subsequent loss of statistical power.…”

Section: Discussionmentioning

confidence: 94%

“…Thus, the use of a summary measure such as glucose tolerance status determined by 2 h OGTT may have obscured the association between Hawaiian ancestry and plasma glucose levels in previous reports. 16 Thus, admixture with ethnic groups in which beta-cell defects may be prevalent and highly inheritable 29 may independently contribute to the high prevalence of type 2 diabetes observed among Native Hawaiians with multiethnic ancestry. It is uncertain whether these differences reflect genetic or culturally determined behavioral factors.…”

Section: Discussionmentioning

confidence: 99%

“…9 -15 A previous study by the Native Hawaiian Health Research Project (NHHR) reported a high prevalence of type 2 diabetes ( > 20%) among Native Hawaiians; however, the association between glucose intolerance and percentage of Hawaiian ancestry (blood quantum) was not significant after adjustment for age. 16 Unlike many other indigenous populations where admixture is largely with a single, lower risk ethnic group (eg Caucasian), the majority of part-Hawaiians reported admixture with two or more ethnic groups (ie Filipino, Portuguese, Chinese), many of which may have high type 2 diabetes risk.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Relationship between plasma glucose concentrations and Native Hawaiian Ancestry: The Native Hawaiian Health Research Project

et al. 2002

View full text Add to dashboard Cite

OBJECTIVE: To investigate the relationship between fasting glucose and 2 h glucose with percentage of Hawaiian ancestry and ethnic admixture. DESIGN: Cross-sectional epidemiological study of type 2 diabetes and heart disease risk factor prevalence among Native Hawaiians. SUBJECTS: A total of 578 Native Hawaiians residing in two rural communities were examined between 1993 and 1996. Sample sizes in statistical analyses varied due to missing data and selection criteria based on ethnic ancestry. MEASUREMENTS: Percentage of Hawaiian ancestry and non-Hawaiian ethnic admixture, assessed by self-report. Fasting and 2 h post glucose challenge plasma glucose levels. Anthropometric measures (height, weight, waist and hip circumferences). Selfreport of diet and physical activity. Medical history. RESULTS: Increased Hawaiian blood quantum was significantly associated with increased fasting glucose (P ¼ 0.0047), increased body mass index (BMI; P < 0.0001), waist-to-hip ratio (WHR; P ¼ 0.0103), and age (P < 0.0001), but not with leisure time physical activity and total dietary caloric intake. This association was attenuated after adjusting for BMI and WHR, but not by age-adjustment alone. However, when the effects of descent from other ethnic groups was examined in a subset of participants, full-Hawaiians had significantly higher fasting glucose concentrations (7.28 mmol=l) than part-Hawaiians after adjustments for age, gender, BMI and WHR. In contrast, part-Hawaiians of predominantly Asian ancestry had the highest 2 h glucose concentrations (7.62 mmol=l). CONCLUSION: These results suggest that ethnic admixture may be an important, but extremely complex, factor concerning the high prevalence of type 2 diabetes observed among this population. The complexity of this relationship may have obscured the relationship between ancestry and glucose tolerance in earlier observations of this population.

show abstract

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Relationship between plasma glucose concentrations and Native Hawaiian Ancestry: The Native Hawaiian Health Research Project

et al. 2002

View full text Add to dashboard Cite

show abstract

“…Hawaii (HI)-The Native Hawaiian Health Research Project, a population-based, crosssectional study to determine the association between cardiovascular risk factors, glucose intolerance, insulin resistance, and ethnicity, conducted a multi-ethnic study from 1997 to 2001 [1,20]. Participants included a comparison cohort of Filipinos, ≥18 years of age, who were recruited from a rural community (North Kohala) on the island of Hawaii, using census data for door-to-door sampling.…”

Section: Study Populationmentioning

confidence: 99%

“…Ethnic disparities in type 2 diabetes prevalence in the United States (US) have been attributed to ethnic differences in adiposity [1][2][3][4][5]. Epidemiologic studies of immigrant populations have shown an increased risk of type 2 diabetes associated with the adoption of a western diet and lifestyle [5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Hyperglycemia and type 2 diabetes among Filipino women in the Philippines, Hawaii, and San Diego

Araneta

Morton

Lantion-Ang

et al. 2006

Diabetes Research and Clinical Practice

Self Cite

View full text Add to dashboard Cite

Background-Diabetes risk increases as immigrant populations adopt western lifestyles. We compared the prevalence of fasting hyperglycemia among Filipino women aged 40-79 years in the Philippines, Hawaii, and San Diego.Methods-Data were obtained from the (1) Philippine National Nutrition Survey (1998), (2) Native Hawaiian Health Research Project (1997)(1998)(1999)(2000)(2001), and (3) University of California San Diego Filipino Women's Health Study (1995)(1996)(1997)(1998)(1999). Fasting glucose after an 8 h fast, blood pressure, and body mass index (BMI) were measured in all three regions; a 75 g oral glucose tolerance test was performed in San Diego and Hawaii.Results-The proportion of Filipinas with BMI ≥ 30 kg/m 2 was higher in Hawaii (20%) compared to women in San Diego (9.3%) or the Philippines (5.2%, p < 0.001). Fasting hyperglycemia prevalence (fasting plasma glucose ≥ 126 mg/dl or fasting whole blood glucose ≥ 110 mg/dl) did not differ among Filipinas in the Philippines (11.8%), San Diego (14.1%), and Hawaii (14.7%, p = 0.323). Type 2 diabetes prevalence was similar among Filipinas in San Diego (31.6%) and Hawaii (24.9%, p = 0.79).Conclusions-Despite regional differences in obesity, fasting hyperglycemia was similar among Filipinas in the Philippines, San Diego, and Hawaii and type 2 diabetes prevalence was similar among Filipinas in San Diego and Hawaii.

show abstract

Socioeconomic Status, Lifestyle, and DNA Methylation Age Among Racially and Ethnically Diverse Adults

Maunakea,

Phankitnirundorn,

Peres

et al. 2024

JAMA Netw Open

View full text Add to dashboard Cite

ImportanceVariation in DNA methylation at specific loci estimates biological age, which is associated with morbidity, mortality, and social experiences. Aging estimates known as epigenetic clocks, including the Dunedin Pace of Aging Calculated From the Epigenome (DunedinPACE), were trained on data predominately from individuals of European ancestry; however, limited research has explored DunedinPACE in underrepresented populations experiencing health disparities.ObjectiveTo investigate associations of neighborhood and individual sociobehavioral factors with biological aging in a racially and ethnically diverse population.Design, Setting, and ParticipantsThis cohort study, part of the Multiethnic Cohort study conducted from May 1993 to September 1996 to examine racial and ethnic disparities in chronic diseases, integrated biospecimen and self-reported data collected between April 2004 and November 2005 from healthy Hawaii residents aged 45 to 76 years. These participants self-identified as of Japanese American, Native Hawaiian, or White racial and ethnic background. Data were analyzed from January 2022 to May 2024.Main Outcomes and MeasuresDNA methylation data were generated from monocytes enriched from cryopreserved lymphocytes and used to derive DunedinPACE scores from November 2017 to June 2021. Neighborhood social economic status (NSES) was estimated from 1990 US Census Bureau data to include factors such as educational level, occupation, and income. Individual-level factors analyzed included educational level, body mass index (BMI), physical activity (PA), and diet quality measured by the Healthy Eating Index (HEI). Linear regression analysis of DunedinPACE scores was used to examine their associations with NSES and sociobehavioral variables.ResultsA total of 376 participants were included (113 [30.1%] Japanese American, 144 [38.3%] Native Hawaiian, and 119 [31.6%] White; 189 [50.3%] were female). Mean (SE) age was 57.81 (0.38) years. Overall, mean (SE) DunedinPACE scores were significantly higher among females than among males (1.28 [0.01] vs 1.25 [0.01]; P = .005); correlated negatively with NSES (R = −0.09; P = .08), HEI (R = −0.11; P = .03), and educational attainment (R = −0.15; P = .003) and positively with BMI (R = 0.31; P &lt; .001); and varied by race and ethnicity. Native Hawaiian participants exhibited a higher mean (SE) DunedinPACE score (1.31 [0.01]) compared with Japanese American (1.25 [0.01]; P &lt; .001) or White (1.22 [0.01]; P &lt; .001) participants. Controlling for age, sex, HEI, BMI, and NSES, linear regression analyses revealed a negative association between educational level and DunedinPACE score among Japanese American (β, −0.005 [95% CI, −0.013 to 0.002]; P = .03) and Native Hawaiian (β, −0.003 [95% CI, −0.011 to 0.005]; P = .08) participants, yet this association was positive among White participants (β, 0.007; 95% CI, −0.001 to 0.015; P = .09). Moderate to vigorous PA was associated with lower DunedinPACE scores only among Native Hawaiian participants (β, −0.006; 95% CI, −0.011 to −0.001; P = .005), independent of NSES.Conclusions and RelevanceIn this study of a racially and ethnically diverse sample of 376 adults, low NSES was associated with a higher rate of biological aging measured by DunedinPACE score, yet individual-level factors such as educational level and physical activity affected this association, which varied by race and ethnicity. These findings support sociobehavioral interventions in addressing health inequities.

show abstract

Prevalence of Glucose Intolerance Among Native Hawaiians in Two Rural Communities

Cited by 60 publications

References 23 publications

Relationship between plasma glucose concentrations and Native Hawaiian Ancestry: The Native Hawaiian Health Research Project

Relationship between plasma glucose concentrations and Native Hawaiian Ancestry: The Native Hawaiian Health Research Project

Hyperglycemia and type 2 diabetes among Filipino women in the Philippines, Hawaii, and San Diego

Socioeconomic Status, Lifestyle, and DNA Methylation Age Among Racially and Ethnically Diverse Adults

Contact Info

Product

Resources

About