Prevalence of growth hormone deficiency in children with cleft lip or palate

Rudman, Daniel; Davis, G. Theodore; Priest, Jean H.; Patterson, Joseph H.; Kutner, Michael; Heymsfield, Steven B.; Bethel, Robert A.

doi:10.1016/s0022-3476(78)81141-x

Cited by 131 publications

(71 citation statements)

References 19 publications

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“…At least 3 previous studies have examined height in school-aged children with ICLP, all of them reporting lower than normal measures for the ICLP group. [31][32][33] Cunningham and Jerome 31 found that the growth trajectories of boys with ICLP are such that although in childhood this group is smaller than expected, normal height could eventually be reached. This is supported by our previous study of men with ICLP, which found the height of the ICLP group to be no different than healthy controls (and in fact, nonsignificantly taller).…”

Section: General Growthmentioning

confidence: 94%

Abnormal Brain Structure in Children With Isolated Clefts of the Lip or Palate

Nopoulos¹,

Langbehn²,

Canady³

et al. 2007

Arch Pediatr Adolesc Med

153

184

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Objective: To evaluate brain structure in a sample of children with isolated clefts of the lip and/or palate (ICLP).Design: Case-control study.Setting: Tertiary care center.Participants: A large sample of 74 children aged 7 to 17 years with ICLP was compared with a healthy control group, matched by age and sex.Main Exposure: Isolated cleft lip and/or palate.Outcome Measures: General measures of height and head circumference were obtained. Brain structure was evaluated using magnetic resonance imaging, generating both general and regional brain measures (volumes).Results: Height was significantly lower in the ICLP group (F=4.83, P=.03). After controlling for this smaller body size, children with ICLP had abnormally small brains with both cerebrum (F = 4.47, P = .04) and cerebellum (F = 14.56, P Ͻ.001) volumes substantially decreased. Within the cerebrum, the frontal lobe was preferentially decreased (F=7.22, P=.008) and subcortical nuclei were also substantially smaller (F=4.18, P=.003). Tissue distribution of cortical gray matter and white matter within the cerebrum were abnormal in boys with ICLP (larger cortical volume, smaller volume of white matter) but proportional to controls in girls with ICLP.Conclusions: Children with ICLP have abnormal brain structure, potentially due to abnormal brain development. The fact that the pattern of brain abnormalities in children with ICLP is dramatically different from the pattern of brain abnormalities seen in adults with ICLP suggests that brain growth and development trajectory is also abnormal in subjects with ICLP.Arch Pediatr Adolesc Med. 2007;161(8):753-758

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Section: General Growthmentioning

confidence: 94%

Abnormal Brain Structure in Children With Isolated Clefts of the Lip or Palate

Nopoulos¹,

Langbehn²,

Canady³

et al. 2007

Arch Pediatr Adolesc Med

153

184

View full text Add to dashboard Cite

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“…There are also case reports of pituitary hormone deficiencies in children and adults who have isolated or syndromic orofacial median clefts (8,9). Only in a few studies were endocrine abnormalities associated with midline cerebral and/or facial anomalies investigated in pediatric patients (10)(11)(12)(13)(14)(15). However, in these studies, the study population was derived from patients who were referred to an endocrinology unit and already had clinical findings of abnormal endocrine functions.…”

Section: Introductionmentioning

confidence: 99%

Endocrine abnormalities of patients with cleft lip and/or cleft palate during the neonatal period

Akın¹,

Kurtoğlu²,

Sarıcı³

et al. 2014

Turk J Med Sci

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IntroductionCultivated strawberry, Fragaria × ananassa, is the natural hybrid of F. chiloensis and F. virginiana and is thought to be only about 300 years old (Hancock, 1999). Earlier researchers have reported that the cultivated strawberry has very narrow genetic diversity when compared with its progenitor species (Dale and Sjulin, 1990;Hancock, 2006;Horvath et al., 2011). Since the progenitor species can easily be crossed with the cultivated strawberry, several attempts have been made to utilize the wild species to expand the genetic base of cultivated strawberry. An example of successful utilization of the wild species includes the introgression of day-neutrality from F. virginiana subsp.

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“…Evidence indicates that psychosocial factors such as parent-infant feeding interactions, infant temperament, social support offered to the mother, and socioeconomic status influence the early growth trajectory of children with clefts, especially during the first three months of life, but subsequent growth is regulated by biological factors. 32 Growth hormone deficiency, which has been studied in children with cleft lip-palate 6,33 and whose effects are already notable during the second or third year of life, requires closer monitoring of these children who are persistently below the lower linear growth percentiles. However, this evidence has been obtained in only a few studies in the literature, which were conducted with a methodology of evaluation of longitudinal growth that differed from that of the present study, and on children of different ages.…”

Section: Discussionmentioning

confidence: 99%

“…One can therefore assume that a child with cleft lip-palate, without associated genetic syndromes, will follow a growth pattern that is reflected in one of the percentiles of the reference curve; thus, deviations from this growth trajectory should be taken into account in the same way as done for a child without clefts. 4,5 In contrast, other investigators [6][7][8][9] have stated that children with congenital malformations or genetic or clinical syndromes follow their own growth pattern, which might differ from that of normal children, and represent groups with their own disease-specific growth pattern. Thus, deviations from these patterns should always be taken into account when assessing a child with a congenital malformation.…”

Section: Introductionmentioning

confidence: 99%

Prejuízo no crescimento de crianças com diferentes tipos de fissura lábio-palatina nos 2 primeiros anos de idade: um estudo transversal

Montagnoli

Barbieri²,

Bettiol³

et al. 2005

J. Pediatr. (Rio J.)

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Objective: To analyze the differences in growth impairment according to sex in the 2 first years of life in children with three types of clefts.Methods: This was a cross-sectional study of 881 children (58.9% boys and 41.1% girls) with cleft lip and palate treated at the Craniofacial Anomaly Rehabilitation Hospital, (University of São Paulo, Bauru, SP), Brazil. Age ranged from 1 to 24 months. Three types of clefts were evaluated: isolated cleft lip (181/20.5%), isolated cleft palate (157/17.8%) and cleft lip + palate (543/61.6%). Weight and length measurements and data regarding breast-feeding and socioeconomic level were obtained. Children with weight and length below the 10th percentile of the NCHS reference were considered to have impaired growth.Results: Sample distribution according to cleft type and sex was similar to that observed in other epidemiological studies. Breastfeeding was more frequent in the isolated cleft lip group (45.9%) then in the isolated cleft palate (12.1%) or cleft lip + palate group (10.5%). Isolated cleft lip children showed less marked impairment of weight (23.8%) and length (19.3%) compared to the cleft lip + palate group (35.7% and 33.1%, respectively). In the latter group, the proportion of children with weight and length below the 10th percentile was very close to that of the isolated cleft palate group (34.4% and 38.9%). Conclusions:The impairment in weight and length was more severe in cleft lip + palate and isolated cleft palate children and may be attributed to feeding difficulties compared to the isolated cleft lip group.J Pediatr (Rio J). 2005;81(6):461-5: Breast-feeding, auxology, nutrition. ResumoObjetivo: Analisar as diferenças no prejuízo do crescimento até os 2 anos de idade, de acordo com o sexo, entre crianças com três tipos de fissuras lábio-palatinas.Métodos: Trata-se de estudo transversal de 881 crianças (58,9% meninos e 41,1% meninas) com fissura lábio-palatina, atendidas no Hospital de Reabilitação de Anomalias Craniofaciais, Universidade de São Paulo, Bauru (SP), com idade entre 1 e 24 meses. Três tipos de fissuras foram avaliados: lábio isolada (181/20,5%), palato isolada (157/17,8%) e lábio+palato (543/61,6%). Foram obtidas medidas de peso e comprimento e informações referentes a aleitamento materno e condições socioeconômicas. Crianças com peso e comprimento abaixo do 10 o percentil da referência do NCHS foram consideradas de risco para crescimento prejudicado.Resultados: A distribuição da amostra segundo tipo de fissura e sexo foi semelhante ao observado em outros estudos epidemiológicos. O aleitamento materno foi mais freqüente entre crianças com fissura labial isolada (45,9%) do que nas de fissura palatina isolada (12,1%) ou fissura de lábio+palato (10,5%). Crianças com fissura labial isolada apresentaram menor comprometimento do peso (23,8%) e comprimento (19,3%), quando comparadas ao grupo de fissura de lábio+palato (35,7% e 33,1%, respectivamente), sendo que este apresentou proporções de crianças com peso e comprimento abaixo do 10 o percentil...

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Prevalence of growth hormone deficiency in children with cleft lip or palate

Cited by 131 publications

References 19 publications

Abnormal Brain Structure in Children With Isolated Clefts of the Lip or Palate

Abnormal Brain Structure in Children With Isolated Clefts of the Lip or Palate

Endocrine abnormalities of patients with cleft lip and/or cleft palate during the neonatal period

Prejuízo no crescimento de crianças com diferentes tipos de fissura lábio-palatina nos 2 primeiros anos de idade: um estudo transversal

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