Prevalence of H. Pylori in Tonsillar Tissue of Patients with Chronic Recurrent Tonsillitis Using Rapid Urease Test in a Tertiary Referral Hospital in Sub Saharan Africa

Ochung’o, O. Peter; Mugwe, Peter; Masinde, Peter; Waweru, Wairimu

doi:10.1007/s12070-014-0754-y

Cited by 9 publications

(10 citation statements)

References 19 publications

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“…This will lead to accumulation of ammonium ion. This will then cause a rise in the pH and this is detected in the pH indicators by a colour change in the system from yellow to pink or red [7].…”

Section: Rapid Urease Testmentioning

confidence: 99%

To Evaluate the Role of H. pylori in Patients with Chronic Recurrent Tonsillitis

Mani

Rekha

Srinivasan

et al. 2018

Indian J Otolaryngol Head Neck Surg

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The usual indication for surgical resection of tonsils is chronic recurrent tonsillitis. Literature also does not indicate the reason behind the fact that only part of the population suffers from recurrent chronic tonsillitis in spite being exposed to similar conditions. This was a prospective study, in which 50 tonsil biopsy samples obtained from chronic tonsillitis patients. Specimens were analysed with rapid urease broth test, HelicotecUT PLUS assay and Toluidine blue staining for presence of Helicobacter pylori. The age ranged from 4 to 34 years. The median age for patients with chronic recurrent tonsillitis was 9.5, 23 (46%) patients were male while 27 (54%) were female, presence of H. pylori by rapid urease broth test, HelicotecUT PLUS assay and Histopathology was 4%. Our analysis revealed that H. pylori did not significantly colonize the tonsils and does not play a role in the pathogenesis or development of chronic tonsillitis. The heterogeneity in study population and methodology may have contributed to the non significant results.

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Section: Rapid Urease Testmentioning

confidence: 99%

To Evaluate the Role of H. pylori in Patients with Chronic Recurrent Tonsillitis

Mani

Rekha

Srinivasan

et al. 2018

Indian J Otolaryngol Head Neck Surg

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“…12 Using a rapid urease test, another report showed that H. pylori was present in 30.5% of the tonsillar tissue of patients with chronic recurrent tonsillitis. 13 The deleterious effects of environmental tobacco smoke (ETS) exposure on the upper respiratory tract of children are becoming increasingly recognized. A previous study showed that there was a significant association between children's sore throats and maternal smoking.…”

Section: 11mentioning

confidence: 99%

The role of environmental tobacco exposure and Helicobacter pylori infection in the risk of chronic tonsillitis in children

et al. 2017

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CONTEXT AND OBJECTIVE: Helicobacter pylori (H. pylori) is a chronic infectious pathogen with high prevalence. This study investigated the interaction between environmental tobacco exposure and H. pylori infection on the incidence of chronic tonsillitis in Chinese children. DESIGN AND SETTING: Cross-sectional study performed in an outpatient clinic in China. METHODS: Pediatric patients with chronic tonsillitis were enrolled. H. pylori infection was determined according to the presence of H. pylori CagA IgG antibodies. Serum cotinine levels and environmental tobacco smoke (ETS) exposure were determined for all participants. RESULTS: There was no significant difference in H. pylori infection between the children with chronic tonsillitis and children free of disease, but there was a significant difference in ETS between the two groups (P = 0.011). We next studied the association between ETS and chronic tonsillitis based on H. pylori infection status. In the patients with H. pylori infection, there was a significant difference in ETS distribution between the chronic tonsillitis and control groups (P = 0.022). Taking the participants without ETS as the reference, multivariate logistic regression analysis showed that those with high ETS had higher susceptibility to chronic tonsillitis (adjusted OR = 2.33; 95% CI: 1.67-3.25; adjusted P < 0.001). However, among those without H. pylori infection, ETS did not predispose towards chronic tonsillitis. CONCLUSION: Our findings suggest that tobacco exposure should be a putative mediator risk factor to chronic tonsillitis among children with H. pylori infection.

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“…Direct and/or indirect mechanisms were involved in association between Hp and upper respiratory tract diseases, various studies over the past two decades have suggested such relationship [13] , where Saki et al [14] detected heavy colonization of HP in adenoid tissue and middle ear, Nártová et al [15] and Ochung'o et al [16] also detected HP in tonsil specimens after tonsillectomy for chronic tonsillitis and sleep apnea syndrome patients.…”

Section: Introductionmentioning

confidence: 99%

Empirical 10-day sequential H. pylori eradication therapy could allow sparing of surgical intervention in chronic rhinosinusitis patients

Fatahalla

Wahba

Hasaneen

2019

Egyptian Journal of Ear, Nose, Throat and Allied Sciences

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Objective:To determine the association between H. pylori (Hp) infection and subjective and objective chronic rhinosinusitis (CRS) parameters and to evaluate the effect of empirical Hp-eradication therapy using the 10-day sequential therapy (ST) on these parameters. Patients and Methods:The study included 85 patients with manifestations of CRS, completed questionnaire to determine total subjective score (TSS) and underwent flexible nasal endoscopy, CT imaging, Urea Breath Test (UBT) and stool Hpantigen test. Patients were divided as Hp+ or Hp-. All patients received 10-day ST and responders were re-evaluated 3-m later, but non-responders were given another 10-day ST course and re-evaluated. Non-responders to ST courses and responders who developed recurrent symptoms underwent FESS. Results: 17 patients (20%) were Hp+; 11 in study and 6 in control groups. 12 Hp+ patients (70.5%) and 23 Hp-patients (33.8%) responded to ST, 5 Hp+ patients were assigned to 2nd ST course and 48 patients underwent FESS. Three of Hp+ patients responded to the 2nd ST course, while two underwent FESS. Seven of the responders to 1 st ST course had recurred manifestations and underwent FESS, while 27 patients completed their follow-up uneventfully. Conclusion: Hp infection may underlie chronicity of CRS and is correlated with severity scores. 10-day ST for Hp eradication is being effective within short-time trial. Empirical ST provided improvement of CRS scoring and spared or postponed surgery in about 31.8% of patients, irrespective of being Hp+ or Hp-, so it is advocated as a first-line trial for patients presenting with symptoms suggestive of CRS.

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Prevalence of H. Pylori in Tonsillar Tissue of Patients with Chronic Recurrent Tonsillitis Using Rapid Urease Test in a Tertiary Referral Hospital in Sub Saharan Africa

Cited by 9 publications

References 19 publications

To Evaluate the Role of H. pylori in Patients with Chronic Recurrent Tonsillitis

To Evaluate the Role of H. pylori in Patients with Chronic Recurrent Tonsillitis

The role of environmental tobacco exposure and Helicobacter pylori infection in the risk of chronic tonsillitis in children

Empirical 10-day sequential H. pylori eradication therapy could allow sparing of surgical intervention in chronic rhinosinusitis patients

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