Prevalence of HBsAg and Anti-HCV in Saudi Blood Donors

Al-Tamimi, Waleed; Altraif, Ibrahim; El‐Sheikh, Mohamed A.; Alkshan, A.; Qasem, Laila; Sohaibani, M.

doi:10.5144/0256-4947.1998.60

Cited by 10 publications

(10 citation statements)

References 10 publications

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“…A prevalence of HBsAg positivity of 4%-5.2% among blood donors in Saudi Arabia has been reported. 2,12 In the present study, the overall prevalence of HBsAg positivity was 3.27%), which is lower than that reported from other regions. Among Saudi blood donors, the prevalence of HBsAg positivity was 1.56% and among non-Saudi blood donors, it was 2.14%.…”

Section: Discussioncontrasting

confidence: 70%

“…In Saudi Arabia, anti-HCV antibody positivity among 0.9%-1.24% of blood donors has been reported. 2,4,9,10 Positivity of anti-HCV antibodies is much higher (24.5%) among the blood donors from other Middle Eastern countries. 5 In the present study prevalence of anti-HCV antibodies among Saudi blood donors in the Al-Hasa region was 0.67% and in non-Saudi blood donors was 3.42%.…”

Section: Discussionmentioning

confidence: 99%

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Prevalence of HbsAg and Anti-HCV Antibodies in Blood Donors of the Al-Hasa Region of Saudi Arabia

Al-Bahrani

Panhotra

2001

Annals of Saudi Medicine

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Hepatitis C virus (HCV) and hepatitis B virus (HBV) are the main causes of post-transfusion hepatitis.1 HBV prevalence among blood donors in the UK and USA has been reported as 0.1-1%. A higher prevalence has been observed in southeastern countries.2 In children, an HBV prevalence rate of 0.3% was reported after the mass vaccination program against HBV in Saudi Arabia. 3 The overall prevalence rate of anti-HCV antibodies among blood donors is 1.5% in Saudi Arabia, 4 which is lower than reported from other Middle Eastern countries. 5 The present study was undertaken to determine the prevalence of HBsAg and anti-HCV antibodies among blood donors in the Al-Hasa region of Saudi Arabia. Patients and MethodsDuring the period of [1987][1988][1989][1990][1991][1992][1993][1994][1995][1996][1997][1998][1999] 95,539 blood donors were screened for HBsAg at King Fahad Hospital, AlHofuf, Al-Hasa. All these donors were 17-55 years of age, with a body weight of more than 55 kg. They were carefully selected after a complete physical examination and answering the donor's questionnaire. Criteria for exclusion of donors was age less than 17 years or more than 55 years, body weight less than 55 kg, hemoglobin less than 13 g, history of jaundice, sickle cell disease, G6PD deficiency, diabetes, hypertension, history of recent fever, and a visit to a malaria-endemic area within one year. These donors were predominantly Saudi males. There were very few female donors who donated for their family members. The sex distribution of these donors was not known. At this time, non-Saudi donors were rarely allowed to donate for their families, however, in 1999 they were encouraged to start donating, in order to meet the increasing requirements of blood in the region.HBsAg was tested by AUSZYME monoclonal enzyme immunoassay (Abbott Laboratories, USA). The beads coated with mouse monoclonal antibodies to HBsAg were incubated with donors' plasma, along with appropriate controls. HBsAg present was bound to solid phase antibodies. The unbound material was aspirated and the beads were washed. Mouse monoclonal antibody to HBsAg conjugated with horseradish peroxidase was allowed to react with antibody-antigen complex on beads. The unbound conjugate was aspirated and beads were washed. Ophenylenediamine solution containing hydrogen peroxide was added to the beads and after incubation development of yellow-orange color more than the cut-off value was taken as positive. The positive samples were confirmed by confirmatory neutralization enzyme immunoassay (Abbott Laboratories, USA).Anti-HCV testing was introduced in 1992. From 1992From -1999,684 blood donors were screened for anti-HCV antibodies. Anti-HCV antibodies were tested by enzyme immunoassay (Murex Diagnostics, UK). The plasma samples were incubated in microwells coated with highly purified antigens containing sequences from core NS3, NS4 and NS5 regions of HCV. The anti-HCV antibodies were bound to the immobilized antigens. The unbound material was removed by washing. The captured anti-HCV antibod...

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Section: Discussioncontrasting

confidence: 70%

Section: Discussionmentioning

confidence: 99%

Prevalence of HbsAg and Anti-HCV Antibodies in Blood Donors of the Al-Hasa Region of Saudi Arabia

Al-Bahrani

Panhotra

2001

Annals of Saudi Medicine

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“…Overall prevalences of HBsAg and anti-HCV were found to be 1.69 and 0.58%, respectively. These results are lower than those previously reported (1,3). We also compared the prevalence rates of HBV and HCV from 1995 to 2002 with those of the period from 1992 to 1994 (Fig.…”

Section: Expansion Of Saudi Blood Donor Pool By Better Screening and mentioning

confidence: 58%

Expansion of Saudi Blood Donor Pool by Better Screening and Vaccination Practices

Tamimi¹,

Hajeer²,

Qasem³

et al. 2003

Clin Vaccine Immunol

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“…Introducing hepatitis B vaccine within the national immunization programmes, improve ment of the people's knowledge about hepatitis risk factors through educa tional programmes, and the availabil ity of measures to diagnose hepatitis in health centres and blood banks might explain this decrease. Many other stud ies in nearby countries have shown a lower prevalence of hepatitis B among blood donors, including Saudi Arabia (4.0%) [11], Egypt (4.3%) [12] and Pakistan (3.3%) [13]. This may be be cause there was insufficient protection for patients admitted to hospitals in Yemen.…”

Section: Discussionmentioning

confidence: 99%

“…Sallam et al reported a prevalence of hepatitis C in 2003 of 0.2 % in Sana'a and 0.6 % in Aden [9]. The prevalence of hepatitis C among blood donors is higher than that reported from the neighbouring countries including Oman (0.5%) and Saudi Arabia (1.0% ) [21,22]. Such small differences in prevalence rates may be explained by methodological differences between studies.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of hepatitis B and C infections and associated factors among blood donors in Aden city, Yemen

Al-Waleedi¹,

Khader²

2012

East Mediterr Health J

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This study determined the prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV ) and associated risk factors among blood donors in Aden city, Yemen. A systematic sample of 469 male blood donors was selected from those attending the national blood bank service in Aden between June and October 2007. Data were collected by questionnaire and blood samples collected. Of the 469 participants, 24 (5.1%) were positive for HBsAg and 6 (1.3%) for anti-HCV. In multivariate analysis, history of: blood transfusion (OR = 22.8), dental treatment (OR = 3.6), cupping (OR = 3.9) and malaria infection (OR = 6.8) were significantly associated with being positive for HBsAg. Those with history of blood donation were less likely to be positive for HBsAg (OR = 0.17). Those with a history of blood donation were significantly less likely to be positive for anti-HCV positivity (OR = 0.05), while those with history of blood transfusion were more likely to test positive (OR = 65.6). The prevalence of HBV and HCV among blood donors in Yemen is still high compared to many other countries.

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Prevalence of HBsAg and Anti-HCV in Saudi Blood Donors

Cited by 10 publications

References 10 publications

Prevalence of HbsAg and Anti-HCV Antibodies in Blood Donors of the Al-Hasa Region of Saudi Arabia

Prevalence of HbsAg and Anti-HCV Antibodies in Blood Donors of the Al-Hasa Region of Saudi Arabia

Expansion of Saudi Blood Donor Pool by Better Screening and Vaccination Practices

Prevalence of hepatitis B and C infections and associated factors among blood donors in Aden city, Yemen

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